TY  - JOUR
A1  - Bertram, Ralph
A1  - Bartsch, Vanessa
A1  - Sodmann, Johanna
A1  - Hennig, Luca
A1  - Müjde, Engin
A1  - Stock, Jonathan
A1  - Ruedig, Vivienne
A1  - Sodmann, Philipp
A1  - Todt, Daniel
A1  - Steinmann, Eike
A1  - Hitzl, Wolfgang
A1  - Steinmann, Joerg
T1  - Risk stratification of SARS-CoV-2 breakthrough infections based on an outbreak at a student festive event
JF  - Vaccines
N2  - In early 2022, the Coronavirus disease 2019 (COVID-19) remains a global challenge. COVID-19 is caused by an increasing number of variants of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Here, we report an outbreak of SARS-CoV-2 breakthrough infections related to a student festive event with 100 mostly vaccinated guests, which took place in Northern Bavaria, Germany, in October 2021. The data were obtained by retrospective guest interviews. In total, 95 students participated in the study, with 94 being fully vaccinated and 24 reporting infection by the delta variant. Correlation analyses among 15 examined variables revealed that time spent at the event, conversation with the supposed index person, and a homologous viral vector vaccination regime were significant risk factors for infection. Non-significant observations related to higher rates of infection included time since last vaccination, shared use of drinking vessels, and number of individual person-to-person contacts at the event. Our data suggest that a high rate of breakthrough infections with the delta variant occurs if no preventive measures are practiced. To limit infection risk, high-quality testing of participants should be considered a mandatory measure at gatherings, irrespective of the participants' vaccination status.
KW  - COVID-19
KW  - SARS-CoV-2
KW  - outbreak
KW  - breakthrough infection
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-267270
SN  - 2076-393X
VL  - 10
IS  - 3
ER  - 
TY  - JOUR
A1  - Tappe, D.
A1  - Stich, A.
A1  - Langeheinecke, A.
A1  - von Sonnenburg, F.
A1  - Muntau, B.
A1  - Schaefer, J.
A1  - Slesak, G.
T1  - Suspected new wave of muscular sarcocystosis in travellers returning from Tioman Island, Malaysia, May 2014
JF  - Eurosurveillance
N2  - In May 2014, six patients presented in Germany with a Sarcocystis-associated febrile myositis syndrome after returning from Tioman Island, Malaysia. During two earlier waves of infections, in 2011 and 2012, about 100 travellers returning to various European countries from the island were affected. While the first two waves were associated with travel to Tioman Island mostly during the summer months, this current series of infections is associated with travel in early spring, possibly indicating an upcoming new epidemic.
KW  - infection
KW  - nesbitti
KW  - outbreak
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-116195
VL  - 19
IS  - 21
ER  - 
TY  - JOUR
A1  - Bielaszewska, Martina
A1  - Schiller, Roswitha
A1  - Lammers, Lydia
A1  - Bauwens, Andreas
A1  - Fruth, Angelika
A1  - Middendorf, Barbara
A1  - Schmidt, M. Alexander
A1  - Tarr, Phillip I.
A1  - Dobrindt, Ulrich
A1  - Karch, Helge
A1  - Mellmann, Alexander
T1  - Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6
JF  - EMBO Molecular Medicine
N2  - Extraintestinal pathogenic and intestinal pathogenic (diarrheagenic) Escherichia coli differ phylogenetically and by virulence profiles. Classic theory teaches simple linear descent in this species, where non-pathogens acquire virulence traits and emerge as pathogens. However, diarrheagenic Shiga toxin-producing E.coli (STEC) O2:H6 not only possess and express virulence factors associated with diarrheagenic and uropathogenic E.coli but also cause diarrhea and urinary tract infections. These organisms are phylogenetically positioned between members of an intestinal pathogenic group (STEC) and extraintestinal pathogenic E.coli. STEC O2:H6 is, therefore, a 'heteropathogen,' and the first such hybrid virulent E.coli identified. The phylogeny of these E.coli and the repertoire of virulence traits they possess compel consideration of an alternate view of pathogen emergence, whereby one pathogroup of E.coli undergoes phased metamorphosis into another. By understanding the evolutionary mechanisms of bacterial pathogens, rational strategies for counteracting their detrimental effects on humans can be developed.
KW  - phased metamorphosis
KW  - phylogeny
KW  - heteropathogenicity
KW  - Shiga toxin-producing Escherichia coli
KW  - hemolytic-uremic syndrome
KW  - urinary-tract-infection
KW  - cytolethal distending toxin
KW  - shiga toxin
KW  - Crohns-disease
KW  - outbreak
KW  - genes
KW  - island
KW  - strains
KW  - parallel evolution
KW  - uropathogenic Escherichia coli
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-117254
SN  - 1757-4684
VL  - 6
IS  - 3
ER  -