TY  - JOUR
A1  - Wang, Shuang
A1  - Sarwat, Mariah
A1  - Wang, Peng
A1  - Surrao, Denver C.
A1  - Harkin, Damien G.
A1  - St John, James A.
A1  - Bolle, Eleonore C. L.
A1  - Forget, Aurelien
A1  - Dalton, Paul D.
A1  - Dargaville, Tim R.
T1  - Hydrogels with Cell Adhesion Peptide‐Decorated Channel Walls for Cell Guidance
JF  - Macromolecular Rapid Communications
N2  - A method is reported for making hollow channels within hydrogels decorated with cell‐adhesion peptides exclusively at the channel surface. Sacrificial fibers of different diameters are used to introduce channels within poly(ethylene glycol) hydrogels crosslinked with maleimide‐thiol chemistry, which are backfilled with a cysteine‐containing peptide solution which is conjugated to the lumen with good spatial efficiency. This allows for peptide patterning in only the areas of the hydrogel where they are needed when used as cell‐guides, reducing the amount of required peptide 20‐fold when compared to bulk functionalization. The power of this approach is highlighted by successfully using these patterned hydrogels without active perfusion to guide fibroblasts and olfactory ensheathing cells—the latter having unique potential in neural repair therapies.
KW  - 3D printing
KW  - cell guidance
KW  - cell transplantation
KW  - melt electrowriting
KW  - synthetic hydrogels
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-218031
VL  - 41
IS  - 15
ER  -