TY  - JOUR
A1  - Pellegrino, Marsha
A1  - Del Bufalo, Francesca
A1  - De Angelis, Biagio
A1  - Quintarelli, Concetta
A1  - Caruana, Ignazio
A1  - de Billy, Emmanuel
T1  - Manipulating the metabolism to improve the efficacy of CAR T-cell immunotherapy
JF  - Cells
N2  - The adoptive transfer of the chimeric antigen receptor (CAR) expressing T-cells has produced unprecedented successful results in the treatment of B-cell malignancies. However, the use of this technology in other malignancies remains less effective. In the setting of solid neoplasms, CAR T-cell metabolic fitness needs to be optimal to reach the tumor and execute their cytolytic function in an environment often hostile. It is now well established that both tumor and T cell metabolisms play critical roles in controlling the immune response by conditioning the tumor microenvironment and the fate and activity of the T cells. In this review, after a brief description of the tumoral and T cell metabolic reprogramming, we summarize the latest advances and new strategies that have been developed to improve the metabolic fitness and efficacy of CAR T-cell products.
KW  - cancer
KW  - metabolic reprogramming
KW  - combined therapy
KW  - Chimeric Antigen Receptor T cells
KW  - immunotherapy
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220140
SN  - 2073-4409
VL  - 10
IS  - 1
ER  -