TY  - JOUR
A1  - Schmalzl, J.
A1  - Plumhoff, P.
A1  - Gilbert, F.
A1  - Gohlke, F.
A1  - Konrads, C.
A1  - Brunner, U.
A1  - Jakob, F.
A1  - Ebert, R.
A1  - Steinert, AF
T1  - The inflamed biceps tendon as a pain generator in the shoulder: A histological and biomolecular analysis
JF  - Journal of Orthopaedic Surgery
N2  - Introduction: The long head of the biceps (LHB) is often resected in shoulder surgery. However, its contribution to inflammatory processes in the shoulder remains unclear. In the present study, inflamed and noninflamed human LHBs were comparatively characterized for features of inflammation. Materials and methods: Twenty-two resected LHB tendons were classified into inflamed (n = 11) and noninflamed (n = 11) samples. For histological examination, samples were stained with hematoxylin eosin, Azan, van Gieson, and Masson Goldner trichrome. Neuronal tissue was immunohistochemically visualized. In addition, specific inflammatory marker gene expression of primary LHB-derived cell cultures were analyzed. Results: Features of tendinopathy, such as collagen disorganization, infiltration by inflammatory cells, neovascularization, and extensive neuronal innervation were found in the tendinitis group. Compared to noninflamed samples, inflamed LHBs showed a significantly increased inflammatory marker gene expression Conclusion: Structural and biomolecular differences of both groups suggest that the LHB tendon acts as an important pain generator in the shoulder joint. These findings can, on the one hand, contribute to the understanding of the biomolecular genesis of LHB tendinitis and, on the other hand, provide possibilities for new therapeutic approaches.
KW  - biceps tendinitis
KW  - biomolecular processes
KW  - inflammatory gene
KW  - interleukin
KW  - long head of biceps tendon
KW  - pain generator
KW  - shoulder pain
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-228611
VL  - 27
IS  - 1
ER  - 
TY  - JOUR
A1  - Konrads, C.
A1  - Hoberg, M.
A1  - Rudert, M.
T1  - New Mechanism of Hip Endoprosthesis Damage Caused by High-frequency Electrocautery
JF  - Journal of Medical Implants & Surgery
N2  - No abstract available.
KW  - endoprothesis
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-146528
VL  - 1
IS  - 1
ER  -