TY  - JOUR
A1  - Herrmann, Marietta
A1  - Engelke, Klaus
A1  - Ebert, Regina
A1  - Müller-Deubert, Sigrid
A1  - Rudert, Maximilian
A1  - Ziouti, Fani
A1  - Jundt, Franziska
A1  - Felsenberg, Dieter
A1  - Jakob, Franz
T1  - Interactions between muscle and bone — Where physics meets biology
JF  - Biomolecules
N2  - Muscle and bone interact via physical forces and secreted osteokines and myokines. Physical forces are generated through gravity, locomotion, exercise, and external devices. Cells sense mechanical strain via adhesion molecules and translate it into biochemical responses, modulating the basic mechanisms of cellular biology such as lineage commitment, tissue formation, and maturation. This may result in the initiation of bone formation, muscle hypertrophy, and the enhanced production of extracellular matrix constituents, adhesion molecules, and cytoskeletal elements. Bone and muscle mass, resistance to strain, and the stiffness of matrix, cells, and tissues are enhanced, influencing fracture resistance and muscle power. This propagates a dynamic and continuous reciprocity of physicochemical interaction. Secreted growth and differentiation factors are important effectors of mutual interaction. The acute effects of exercise induce the secretion of exosomes with cargo molecules that are capable of mediating the endocrine effects between muscle, bone, and the organism. Long-term changes induce adaptations of the respective tissue secretome that maintain adequate homeostatic conditions. Lessons from unloading, microgravity, and disuse teach us that gratuitous tissue is removed or reorganized while immobility and inflammation trigger muscle and bone marrow fatty infiltration and propagate degenerative diseases such as sarcopenia and osteoporosis. Ongoing research will certainly find new therapeutic targets for prevention and treatment.
KW  - muscle
KW  - bone
KW  - mechanosensing
KW  - mechanotransduction
KW  - myokines
KW  - osteokines adaptation
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-203399
SN  - 2218-273X
VL  - 10
IS  - 3
ER  -