TY  - JOUR
A1  - Chapdelaine, Isabelle
A1  - de Roij van Zuijdewijn, Camiel L.M.
A1  - Mostovaya, Ira M.
A1  - Lévesque, Renée
A1  - Davenport, Andrew
A1  - Blankestijn, Peter J.
A1  - Wanner, Christoph
A1  - Nubé, Menso J.
A1  - Grooteman, Muriel P.C.
T1  - Optimization of the convection volume in online post-dilution haemodiafiltration: practical and technical issues
JF  - Clinical Kidney Journal
N2  - In post-dilution online haemodiafiltration (ol-HDF), a relationship has been demonstrated between the magnitude of the convection volume and survival. However, to achieve high convection volumes (>22 L per session) detailed notion of its determining factors is highly desirable. This manuscript summarizes practical problems and pitfalls that were encountered during the quest for high convection volumes. Specifically, it addresses issues such as type of vascular access, needles, blood flow rate, recirculation, filtration fraction, anticoagulation and dialysers. Finally, five of the main HDF systems in Europe are briefly described as far as HDF prescription and optimization of the convection volume is concerned.
KW  - convection volume
KW  - haemodiafiltration
KW  - dialysis
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150020
VL  - 8
IS  - 2
ER  - 
TY  - JOUR
A1  - Mostovaya, Ira M.
A1  - Grooteman, Muriel P.C.
A1  - Basile, Carlo
A1  - Davenport, Andrew
A1  - de Roij van Zuijdewijn, Camiel L.M.
A1  - Wanner, Christoph
A1  - Nubé, Menso J.
A1  - Blankestijn, Peter J.
T1  - High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs
JF  - Clinical Kidney Journal
N2  - Increasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusive results, post hoc analyses of these and previous observational studies comparing online post-dilution HDF with HD showed that the risk of overall and cardiovascular mortality is lowest in patients who are treated with high-volume HDF. As such, the magnitude of the convection volume seems crucial and can be considered as the ‘dose’ of HDF. In this narrative review, the relevance of high convection volume in online post-dilution HDF is discussed. In addition, we briefly touch upon some safety and cost issues.
KW  - convection volume
KW  - costs
KW  - hemodiafiltration
KW  - mortality
KW  - safety
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149814
VL  - 8
IS  - 4
ER  -