TY  - JOUR
A1  - El-Hossary, Ebaa M.
A1  - Abdel-Halim, Mohammad
A1  - Ibrahim, Eslam S.
A1  - Pimentel-Elardo, Sheila Marie
A1  - Nodwell, Justin R.
A1  - Handoussa, Heba
A1  - Abdelwahab, Miada F.
A1  - Holzgrabe, Ulrike
A1  - Abdelmohsen, Usama Ramadan
T1  - Natural Products Repertoire of the Red Sea
JF  - Marine Drugs
N2  - Marine natural products have achieved great success as an important source of new lead compounds for drug discovery. The Red Sea provides enormous diversity on the biological scale in all domains of life including micro- and macro-organisms. In this review, which covers the literature to the end of 2019, we summarize the diversity of bioactive secondary metabolites derived from Red Sea micro- and macro-organisms, and discuss their biological potential whenever applicable. Moreover, the diversity of the Red Sea organisms is highlighted as well as their genomic potential. This review is a comprehensive study that compares the natural products recovered from the Red Sea in terms of ecological role and pharmacological activities.
KW  - Red Sea
KW  - marine natural products
KW  - marine organisms
KW  - biodiversity
KW  - marine metagenomics
KW  - bioactivity
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-213110
SN  - 1660-3397
VL  - 18
IS  - 9
ER  - 
TY  - JOUR
A1  - Pimentel-Elardo, Sheila Marie
A1  - Grozdanov, Lubomir
A1  - Proksch, Sebastian
A1  - Hentschel, Ute
T1  - Diversity of Nonribosomal Peptide Synthetase Genes in the Microbial Metagenomes of Marine Sponges
N2  - Genomic mining revealed one major nonribosomal peptide synthetase (NRPS) phylogenetic cluster in 12 marine sponge species, one ascidian, an actinobacterial isolate and seawater. Phylogenetic analysis predicts its taxonomic affiliation to the actinomycetes and hydroxy-phenyl-glycine as a likely substrate. Additionally, a phylogenetically distinct NRPS gene cluster was discovered in the microbial metagenome of the sponge Aplysina aerophoba, which shows highest similarities to NRPS genes that were previously assigned, by ways of single cell genomics, to a Chloroflexi sponge symbiont. Genomic mining studies such as the one presented here for NRPS genes, contribute to on-going efforts to characterize the genomic potential of sponge-associated microbiota for secondary metabolite biosynthesis.
KW  - Biologie
KW  - nonribosomal peptide synthetase
KW  - NRPS
KW  - marine sponge
KW  - Porifera
KW  - metagenomics
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-75990
ER  - 
TY  - JOUR
A1  - Pimentel-Elardo, Sheila Marie
A1  - Kozytska, Svitlana
A1  - Bugni, Tim S.
A1  - Ireland, Chris M.
A1  - Moll, Heidrun
A1  - Hentschel, Ute
T1  - Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges
N2  - Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp. strains from Mediterranean sponges, on their secondary metabolite production and on their screening for anti-infective activities. Bioassay-guided isolation and purification yielded three previously known compounds namely, cyclic depsipeptide valinomycin, indolocarbazole alkaloid staurosporine and butenolide. This is the first report of the isolation of valinomycin from a marine source. These compounds exhibited novel anti-parasitic activities specifically against Leishmania major (valinomycin IC50 < 0.11 μM; staurosporine IC50 5.30 μM) and Trypanosoma brucei brucei (valinomycin IC50 0.0032 μM; staurosporine IC50 0.022 μM; butenolide IC50 31.77 μM). These results underscore the potential of marine actinomycetes to produce bioactive compounds as well as the re-evaluation of previously known compounds for novel anti-infective activities.
KW  - Biologie
KW  - marine sponges
KW  - Streptomyces
KW  - valinomycin
KW  - staurosporine
KW  - butenolide
KW  - anti-parasitic
Y1  - 2010
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-68312
ER  -