TY  - JOUR
A1  - Walther, Kay-Arne
A1  - Gonzales, José Roberto
A1  - Gröger, Sabine
A1  - Ehmke, Benjamin
A1  - Kaner, Dogan
A1  - Lorenz, Katrin
A1  - Eickholz, Peter
A1  - Kocher, Thomas
A1  - Kim, Ti-Sun
A1  - Schlagenhauf, Ulrich
A1  - Koch, Raphael
A1  - Meyle, Jörg
T1  - The role of polymorphisms at the Interleukin-1, Interleukin-4, GATA-3 and Cyclooxygenase-2 genes in non-surgical periodontal therapy
JF  - International Journal of Molecular Sciences
N2  - Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent maintenance in a Caucasian population. Analyses were performed using blood samples from periodontitis patients of a multi-center trial (ClinicalTrials.gov NCT00707369=ABPARO-study). Polymorphisms were analyzed using quantitative real-time PCR. Clinical attachment levels (CAL), percentage of sites showing further attachment loss (PSAL) ≥1.3 mm, bleeding on probing (BOP) and plaque score were assessed. Exploratory statistical analysis was performed. A total of 209 samples were genotyped. Patients carrying heterozygous genotypes and single-nucleotide-polymorphisms (SNP) on the GATA-3-IVS4 +1468 gene locus showed less CAL loss than patients carrying wild type. Heterozygous genotypes and SNPs on the IL-1A-889, IL-1B +3954, IL-4-34, IL-4-590, GATA-3-IVS4 +1468 and COX-2-1195 gene loci did not influence CAL. In multivariate analysis, CAL was lower in patients carrying GATA-3 heterozygous genotypes and SNPs than those carrying wild-types. For the first time, effects of different genotypes were analyzed in periodontitis progression after periodontal therapy and during supportive treatment using systemic antibiotics demonstrating a slight association of GATA-3 gene locus with CAL. This result suggests that GATA-3 genotypes are a contributory but non-essential risk factor for periodontal disease progression.
KW  - periodontitis
KW  - polymorphisms
KW  - risk factor
KW  - periodontal therapy
KW  - antibiotics
KW  - GATA-3
KW  - Interleukin-1
KW  - Interleukin-4
KW  - Cyclooxygenase-2
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284386
SN  - 1422-0067
VL  - 23
IS  - 13
ER  - 
TY  - JOUR
A1  - Matern, Johannes
A1  - Koch, Raphael
A1  - Petersmann, Astrid
A1  - Kocher, Thomas
A1  - Eickholz, Peter
A1  - Lorenz, Katrin
A1  - Kim, Ti‐Sun
A1  - Meyle, Jörg
A1  - Kaner, Doğan
A1  - Schlagenhauf, Ulrich
A1  - Gravemeier, Martina
A1  - Harks, Inga
A1  - Ehmke, Benjamin
T1  - Effect of periodontal therapy on adipokine biomarkers in overweight
JF  - Journal of Clinical Periodontology
N2  - Aim
The aim of this study was to evaluate the effect of non‐surgical periodontal therapy on circulating levels of the systemic inflammation‐associated biomarkers orosomucoid (ORM), high‐sensitivity C‐reactive protein (hsCRP), chemerin, and retinol‐binding protein 4 (RBP4) in overweight or normal‐weight patients with periodontitis at 27.5 months after therapy.

Materials and methods
This exploratory subanalysis includes patients from the ABPARO‐trial (ClinicalTrials.gov NCT00707369). The per‐protocol collective provided untreated periodontitis patients with high (≥28 kg/m\(^{2}\)) or moderate (21–24 kg/m\(^{2}\)) BMI. Out of the per‐protocol collective, 80 patients were randomly selected and stratified for BMI group, sex, and treatment group (antibiotics/placebo), resulting in 40 overweight and normal‐weight patients. Patients received non‐surgical periodontal therapy and maintenance at 3‐month intervals. Plasma samples from baseline and 27.5 months following initial treatment were used to measure the concentrations of ORM, hsCRP, chemerin, and RBP4.

Results
At the 27.5‐month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM: p = .001, hsCRP: p = .004) and normal‐weight patients (ORM: p = .007, hsCRP: p < .001). Chemerin decreased in the overweight group (p = .048), and RBP4 concentrations remained stable.

Conclusion
Non‐surgical periodontal therapy reduced systemically elevated inflammation‐associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal‐weight patients.
KW  - chemerin
KW  - orosomucoid
KW  - overweight
KW  - periodontitis
KW  - retinol‐binding protein 4
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-215546
VL  - 47
IS  - 7
SP  - 842
EP  - 850
ER  -