TY - JOUR
A1 - Lambert, Christoph
A1 - Kaupp, Martin
A1 - Schleyer, Paul von Rague
T1 - “Inverted” Sodium-Lithium Electronegativity: Polarity and Metalation Energies of Organic and Inorganic Alkali-Metal Compounds
N2 - No abstract available
KW - Anorganische Chemie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-60054
ER -
TY - JOUR
A1 - Schliewen, U.
A1 - Fricke, H.
A1 - Schartl, Manfred
A1 - Epplen, Jörg T.
A1 - Paabo, S.
T1 - Which home for coelacanth?
N2 - No abstract available
KW - Physiologische Chemie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61606
ER -
TY - JOUR
A1 - Falk, Michael
A1 - Marohn, Frank
T1 - Von Mises condition revisited
N2 - It is shown that the rate of convergence in the von Mises conditions of extreme value theory determines the distance of the underlying distribution function F from a generalized Pareto distribution. The distance is measured in terms of the pertaining densities with the limit being ultimately attained if and only if F is ultimately a generalized Pareto distribution. Consequently, the rate of convergence of the extremes in an lid sample, whether in terms of the distribution of the largest order statistics or of corresponding empirical truncated point processes, is determined by the rate of convergence in the von Mises condition. We prove that the converse is also true.
KW - Von Mises conditions
KW - extreme value theory
KW - extreme value distribution
KW - extreme order statistics
KW - generalized Pareto distribution
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45790
ER -
TY - JOUR
A1 - Kruse, N.
A1 - Shen, B. J.
A1 - Arnold, S.
A1 - Tony, H. P.
A1 - Müller, T.
A1 - Sebald, Walter
T1 - Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation
N2 - Interleukin 4 (IL-4) exerts a decisive role in the coord.ination of proteelive immune responses against parasites, particularly helminths. A disregulation of ll.r4 function is possibly involved in the genesis of allergic disease states. The search for important amino acid residues in human ll.r4 by mutational analysis of charged invariant amino acid positions identified two distinct functional sites in the 4-helix-bundle protein. Site 1 was marked by amino acid substitutions of the glutamic acid at position 9 in helix A and arginine at position 88 in helix C. Exchanges at both positions led to IL-4 variants deficient in binding to the extracellular domain of the ll.r4 receptor (IL-4ReJ. In parallel, up to 1000-fold increased concentrations of this type of variant were required to induce T -cell proliferation and B-eeil CD23 expression. Site 2 was marked by amino acid exchanges in helix D at positions 121, 124 and 125 (arginine, tyrosine and serine respectively in the wild-type).ß.A variants affected at site 2 exhibited partial agonist activity during T -cell proliferation; however, they still bound with high affinity to IL-4Rex. [The generation of an IL-4 antagonist by replacing tyrosine 124 with aspartic acid has been described before by Kruse et al. (1992) (EMBO }., 11, 3237-3244)]. These findings indicate that IL-4 functions by bind.ing IL-4Rex via site 1 which is constituted by residues on helices A and C. They further suggest that the association of a second, still undetined receptor protein with site 2 in helix D activates the receptor system and generates a transmembrane signal.
KW - Biochemie
KW - drug design/partial agonists
KW - receptor signalling
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62451
ER -
TY - JOUR
A1 - Adam, Dieter
A1 - Dimitrijevic, Nicola
A1 - Schartl, Manfred
T1 - Tumor suppression in Xiphophorus by an accidentally acquired promoter
N2 - Melanoma formation in the teleost Xiphophorus is caused by a dominant genetic locus, Tu. This locus includes the Xmrk oncogene, which encodes a receptor tyrosine kinase. Tumor induction is. suppressed in wild-type fish by a tumor suppressor locus, R. Molecular genetic analyses revealed that the Tu locus emerged by nonhomologaus recombination of the Xmrk proto-oncogene with a previously uncharacterized sequence, D. This event generated an additional copy of Xmrk with a new promoter. Suppression of the new Xmrk promoter by R in parental fish and its deregulation in hybrids explain the genetics of melanoma formation in Xiphophorus.
KW - Physiologische Chemie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61630
ER -
TY - JOUR
A1 - Thoenen, Hans
A1 - Hughes, Richard A.
A1 - Sendtner, Michael
T1 - Trophic support of motoneurons: physiological, pathophysiological, and therapeutic implications.
N2 - No abstract available
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31746
ER -
TY - JOUR
A1 - Brabletz, Thomas
A1 - Pfeuffer, Isolde
A1 - Schorr, Elke
A1 - Siebelt, Friederike
A1 - Wirth, Thomas
A1 - Serfling, Edgar
T1 - Transforming growth factor \(\beta\) and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site
N2 - Transforming growth factor \(\beta\) (TGF-\(\beta\)) has a growth-inhibitory effect on numerous different cell types of the immune system, including T lymphocytes. We show in this study that the inhibitory action of TGF-\(\beta\) on T lymphocytes is accompanied by a block of interleukin 2 (IL-2) gene expression which is mediated, at least in part, by inhibition of IL-2 promoter/enhancer activity. The functional analysis of cis-regulatory (protoenhancer) elements of the IL-2 enhancer/promoter region showed that the most TGF-\(\beta\)-responsive element maps to its so-called upstream promoter site. The proto-enhancer activity of the upstream promoter site element is also inhibited by cyclosporin A. The upstream promoter site DNA harbors two noncanonical, closely linked binding sequences for octamer and AP-1-like factors. Both sites are involved in the establishment of IL-2 enhancer activity. Since the activity of genuine octamer sites but not that of AP-1-binding sites is also impaired by TGF-\(\beta\) and cyclosporin A in E14 T lymphoma cells, we conclude that both immunosuppressives interfere with the activity but not the DNA binding of octamer factors in T lymphocytes.
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31199
ER -
TY - JOUR
A1 - Morschhäuser, J.
A1 - Uhlin, B. E.
A1 - Hacker, Jörg
T1 - Transcriptional analysis and regulation of the sfa determinant coding for S fimbria of pathogenic E. coli strains
N2 - The sfa determinant codes for S fimbrial adhesins which constitute adherence factors of pathogenic Escherichia coli strains. Wehave recently shown that the sfa determinant is transcribed from three prömoters, pA, pB, and pC. In comparison with the promoters pB and pC, promoter pA, which is located in front of the structural gene sfaA, showed very weak activity. Herewe have determined the exact positions ofthe mRNA start points by primer extension studies. We have also shown that mRNAs of 500, 700 and 1400 bases can be detected using oligonucleotide probes specific for the genes sfaB, sfaC and sfaA. SfaB and SfaC arepositive regulators infiuencing fimbriation and the production of the S-specific adhesin which is encoded by the gene sfaS Iocated in the distal half of the determinant. In addition, it is demonstrated that SfaB and SfaC interfere with the regulatory effect of the histone-like protein H-NS, encoded by a locus termed drdX or osmZ. In a drdx+ strain the regulators are necessary for transcription of the sfa determinant. In contrast, sfa expression is activator-independent in a drdx- strain. In this latter genetic background, a substantial fraction of the sfa transcripts is initiated from promoter pA. On the basis of these data we discuss a model for the regulation of this adhesin-specific determinant.
KW - Infektionsbiologie
KW - Gene regulation
KW - Fimbriae
KW - Adhesion
KW - Transcription
KW - trans-activation
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59844
ER -
TY - CHAP
A1 - Thoenen, Hans
A1 - Hughes, Richard A.
A1 - Sendtner, Michael
T1 - Towards a comprehensive understanding of the trophic support of motoneurons
N2 - Motoneurons played an essential role in establishing the concept of target-mediated support of innervating neurons. However, it took several decades until molecules were identined which trophically support motoneurons in vitro and in vivo. The most potent molecule identined so far is ciliary neurotrophic factor (CNTF). It is expressed as a cytosolic molecule in myelinating Schwann cells rather than in skeletal muscle in the postnatal period and therefore does not qualify as a target-derived neurotrophic factor regulating motoneuron survival during embryonic development. However, the inactivation of CNTF by gene targeting experiments results in progressive atrophy and degeneration of motoneurons, demonstrating that CNTF plays an essential role as a maintenance factor for motoneurons postnatally. Secretory molecules which are expressed in skeletal muscle during embryonic development and which support motoneurons in culture and partially also in vivo include members of the NGF gene family (BDNF, NT-3, NT-4/S) , FGF-S, IGF-I, and UF. The evaluation of the physiological importance of these molecules is under investigation.
KW - neurotrophic molecules
KW - CNTF
KW - gene targeting
KW - NGF gene family
KW - FGF-5
KW - lIF
KW - IGF-I
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31117
ER -
TY - JOUR
A1 - Waelbroeck, M.
A1 - Camus, J.
A1 - Tastenoy, M.
A1 - Lambrecht, G.
A1 - Mutschler, E.
A1 - Kropfgans, M.
A1 - Sperlich, J.
A1 - Wiesenberger, F.
A1 - Tacke, R.
A1 - Christophe, J.
T1 - Thermodynamics of antagonist binding to rat muscarinic \(M_2\) receptors: antimuscarinics of the pridinol, sila-pridinol, diphenidol and sila-diphenidol type
JF - British Journal of Pharmacology
N2 - 1 We studied the effect of temperature on the binding to rat heart \(M_2\) muscarinic receptors of antagonists related to the carbon/silicon pairs pridinol/sila-pridinol and diphenidol/sila-diphenidol (including three germanium compounds) and six structurally related pairs of enantiomers [(R)- and (S)-procyclidine, (R)- and (S)-trihexyphenidyl, (R)- and (S)-tricyclamol, (R)- and (S)-trihexyphenidyl methiodide, (R)- and (S)-hexahydro-diphenidol and (R)- and (S)-hexbutinol]. Binding affinities were determined in competition experiments using \([^3H]\)-N-methyl-scopolamine chloride as radioligand. The reference drugs were scopolamine and N-methyl-scopolamine bromide.
2 The affinity of the antagonists either increased or decreased with temperature, van 't Hoff plots were linear in the 278–310°K temperature range. Binding of all antagonists was entropy driven. Enthalpy changes varied from large negative values (down to \(−29 kJ mol^{−1}\)) to large positive values (up to \(+ 30 kJ mol^{−1}\)).
3 (R)-configurated drugs had a 10 to 100 fold greater affinity for \(M_2\) receptors than the corresponding (S)-enantiomers. Enthalpy and entropy changes of the respective enantiomers were different but no consistent pattern was observed.
4 When silanols \((R_3SiOH)\) were compared to carbinols \((R_3COH)\), the affinity increase caused by C/Si exchange varied between 3 and 10 fold for achiral drugs but was negligible in the case of chiral drugs. Silanols induced more favourable enthalpy and less favourable entropy changes than the corresponding carbinols when binding. Organogermanium compounds \((R_4Ge)\) when compared to their silicon counterparts (R4Si) showed no significant difference in affinity as well as in enthalpy and entropy changes.
5 Exchange of a cyclohexyl by a phenyl moiety was associated with an increase or a decrease in drug affinity (depending on the absolute configuration in the case of chiral drugs) and generally also with a more favourable enthalpy change and a less favourable entropy change of drug binding.
6 Replacement of a pyrrolidino by a piperidino group and increasing the length of the alkylene chain bridging the amino group and the central carbon or silicon atom were associated with either an increase or a decrease of entropy and enthalpy changes of drug binding. However, there was no clear correlation between these structural variations and the thermodynamic effects.
7 Taken together, these results suggest that hydrogen bond-forming OH groups and, to a lesser extent, polarizable phenyl groups contribute significantly to the thermodynamics of interactions between these classes of muscarinic antagonists and \(M_2\) muscarinic receptors.
KW - entropy
KW - binding
KW - M2 muscarinic receptors
KW - thermodynamics
KW - van 't Hoff plot
KW - enthalpy
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128439
VL - 109
IS - 2
ER -
TY - JOUR
A1 - Müller, J.
A1 - Krenn, V.
A1 - Czub, S.
A1 - Schindler, C.
A1 - Kneitz, C.
A1 - Kerkau, T.
A1 - Stahl-Henning, C.
A1 - Coulibaly, C.
A1 - Hunsmann, G.
A1 - Rethwilm, Axel
A1 - ter Meulen, Volker
A1 - Müller-Hermelink, H. K.
T1 - The thymus in SIV infection
N2 - no abstract available
KW - HIV-Infektion
KW - Tierversuch
KW - Tiermodell
KW - Retroviren-Infektion
KW - Kongress
KW - Hamburg
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-80265
ER -
TY - JOUR
A1 - Lutz, Werner K.
A1 - Schlatter, Josef
T1 - The relative importance of mutagens and carcinogens in the diet.
N2 - Known mutagens and carcinogens in the dict were compiled and the risk of cancer was estimated on the basis of average exposure Ievels in Switzerland and carcinogenic potencies from rodent bioassays. The analysis showed that, except for a1cohol, the sum of all known dietary carcinogens could only explain a few percent of the cancer deaths attributed by epidemiologists to dietary factors. The discrepancy was explained by a "carcinogenicity" of excess macronutrients. This hypothesis was based on an evaluation of dietary restriction experiments in rats and mice, where a dramatic reducing effect on spontaneaus tumour formation was seen. From these experiments, a "carcinogenic potency" was deduced for food in excess (TD50 approximately 16 g/kg per day). Ovemutrition in Switzerland was converted into excess food intake and the cancer risk estimated on the basis ofthe TD50 value. The resulting risk of60,000 cases per one million lives wou1d aJlow to explain by overnutrition almost all "diet-related" cancer deaths in humans.
KW - Medizin
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86311
ER -
TY - JOUR
A1 - Kaupp, Martin
A1 - Schleyer, Paul von Rague
T1 - The Peculiar Coordination of Brium: Ab Initio Study of the Molecular and Electronic Structures of the Group 2 Dihydride Dimers M\(_2\)H\(_4\) (M=Mg, Ca, Sr, Ba)
N2 - No abstract available
KW - Anorganische Chemie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-60048
ER -
TY - CHAP
A1 - Schneider, Wolfgang
T1 - The longitudinal study of motor development: methodological issues
N2 - No abstract available.
KW - Motorische Entwicklung
KW - Längsschnittuntersuchung
KW - Methode
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-71393
ER -
TY - JOUR
A1 - Schneider, Wolfgang
A1 - Näslund, Jan Carol
T1 - The impact of early metalinguistic competencies and memory capacity on reading and spelling in elementary school: Results of the Munich Longitudinal Study on the Genesis of Individual Competencies (LOGIC)
N2 - This paper reports on a longitudinal study dealing with the development of literacy in young children. A total of 163 children were first tested during their last year in kindergarten using a variety of tasks that tapped phonological processing, memory capacity, early literacy, and intelligence. Children's ward decoding, reading comprehension, and spelling skills were assessed in elementary school several years later. As a main result, all of the predictor domains had a significant impact on the acquisition of literacy in elementary school, although the contribution of each domain differed as a function of the criterion measure. An attempt to identify children-at-risk using a kindergarten screening test provided encouraging results. Nonetheless, it was shown that whereas group predictions of reading and spelling performance can be quite accurate, the individual prognosis of school problems is far from perfect.
KW - Lese- und Schreibfähigkeit
KW - Gedächtnisleistung
KW - Phonologische Bewusstheit
KW - Acquisition of literacy
KW - Children-at-Risk
KW - Memory capacity
KW - Phonological awareness
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87421
ER -
TY - JOUR
A1 - Becker, Charles R.
A1 - He, L.
A1 - Regnet, M. M.
A1 - Kraus, M.M.
A1 - Wu, Y. S.
A1 - Landwehr, G.
A1 - Zhang, X. F.
A1 - Zhang, H.
T1 - The growth and structure of short period (001) Hg\(_{1-x}\)Cd\(_x\)Te-HgTe superlattices
N2 - Molecular beam epitaxially grown short period (001) Hg\(_{1_x}\)Cd\(_x\)Te-HgTe superlattices have been systematically investigated. Several narrow well widths were chosen, e.g., 30, 35 and 40 Å, and the barrier widths were varied between 24 and 90 Å for a particular well width. Both the well width and the total period were determined directly by means of x-ray diffraction. The well width was determined by exploiting the high reflectivity from HgTe and the low reflectivity from CdTe for the (002) Bragg reflection. Knowing the well and barrier widths we have been able to set an upper limit on the average Cd concentration of the barriers, \(\overline x_b\), by annealing several superlattices and then measuring the composition of the resulting alloy. \(\overline x_b\) was shown to decrease exponentially with decreasing barrier width. The structure of a very short period superlattice, i.e., 31.4 Å, was also investigated by transmission electron microscopy, corroborating the x-ray diffraction results.
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37858
ER -
TY - JOUR
A1 - Dandekar, Thomas
A1 - Argos, P.
T1 - The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted \(\alpha\)-helices: Crystal structure of the protein DNA-complex
N2 - No abstract available
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-29866
ER -
TY - JOUR
A1 - Weisenberger, Dieter
A1 - Scheer, Ulrich
A1 - Benavente, Ricardo
T1 - The DNA topoisomerase I inhibitor camptothecin blocks postmitotic reformation of nucleoli in mammmalian cells
N2 - No abstract available
KW - Cytologie
KW - Nucleolus-DNA
KW - opoisomerase I
KW - camptothecin
KW - mitosis
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41434
ER -
TY - JOUR
A1 - Wilhelm, Gernot
A1 - Zaccagnini, Carlo
T1 - Tell Karrana 3, Tell Jikan, Tell Khirbet Salih
N2 - No abstract available.
KW - Tell Karrana
KW - Tell Jikan
KW - Tell Khirbet Salih
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87646
ER -
TY - JOUR
A1 - Tacke, Reinhold
A1 - Wagner, S. A.
A1 - Brakmann, S.
A1 - Wuttke, F.
A1 - Eilert, U.
A1 - Fischer, L.
A1 - Syldatk, C.
T1 - Synthesis of acetyldimethyl(phenyl)silane and its enantioselective conversion into (R)-(1-hydroxyethyl)dimethyl(phenyl)silane by plant cell suspension culytures of Symphytum officinale L. and Ruta graveolens L.
N2 - Starting from chlorodimethyl(phenyl)silane (3), acetyldimethyl(phenyl)silane (l) was prepared by a two-step synthesis in a total yield of 90% [PhMe\(_2\)SiCl (3)-> PhMe\(_2\)SiCCOMe)=CH\(_2\) (4)-> PhMe\(_2\)SiC(O)Me (1)]. The prochiral acetylsilane 1 was transfonned enantioselectively into (R)-(1-hydroxyethyl)dimethyl(phenyl)silane [(R)-2] using plant cell Suspension cultures of Symphytum officinale L. or Ruta graveolens L. Under preparative conditions (300-mg scale, not optimized), (R)-2 was isolated in 15% (Symphytum) and 9% yield (Ruta), respectively. The enantiomeric purities of the products were 81% ee (Syrnphytum) and 60% ee (Ruta), respectively.
KW - Anorganische Chemie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64299
ER -
TY - JOUR
A1 - Heller, Eberhard
A1 - Herdeis, Claus
T1 - Synthesis of 2S,5S- and 2R,5S-5-Hydroxypipecolic Acid via Amide-Methylenation of S-5-Hydroxy-2-piperidone with Dimethyltitanocene
N2 - A route to 2S,5S-and 2R,5S-hydroxypipecolic acid is presented, starting with the enantiopure 5S-5-hydroxy-piperidone 7. The key step of this reaction sequence is the chemoselsctive methylenation of the amide carbonyl group of 8 with dimethyltitanocene 9 to 10. The transformation of the exocyclic enecarbamate double bond to the carboxylic acid group is best accomplished via hydroboration/oxidation to the alcohol 11a,b. Separation and oxidation of the dlastereomers 11a,b, to 148. and 14b, and hydrolysis furnishes the diastereomeric pipecolic acids 15a and 15b in enantiopure form.
KW - Chemie
KW - Asymmetrie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38288
ER -
TY - JOUR
A1 - Tacke, Reinhold
A1 - Becht, J.
A1 - Lopez-Mras, A.
A1 - Sheldrick, W. S.
A1 - Sebald, A.
T1 - Syntheses, X-ray crystal structure analyses, and solid-state NMR studies of some zwitterionic organofluorosilicates
N2 - No abstract available
KW - Anorganische Chemie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64272
ER -
TY - JOUR
A1 - Arbuznikov, Alexey V.
A1 - Plakhutin, A. B.
T1 - Symmetric vector coupling coefficients for atomic non-Roothaan states in the d\(^N\) configuration
N2 - No abstract available
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47062
ER -
TY - JOUR
A1 - Wu, Y. S.
A1 - Becker, Charles R.
A1 - Waag, A.
A1 - von Schierstedt, K.
A1 - Bicknell-Tassius, R. N.
A1 - Landwehr, G.
T1 - Surface sublimation of zinc blende CdTe
N2 - The surface sublimation of Cd and Te atoms from the zinc blende (111)A CdTe surface has been investigated in detail by reflection high energy electron diffraction and x-ray photoelectron spectroscopy. These experiments verify that Te is much easier to evaporate than Cd. The experimental value for the Te activation energy from a Te stabilized (111)A CdTe surface is 1.41 ±0.1O eV, which is apparently inconsistent with recent theoretical results.
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37829
ER -
TY - JOUR
A1 - Schüssler, Ulrich
A1 - Skinner, David N. B.
A1 - Roland, Norbert W.
T1 - Subduction-related Mafic to Intermediate Plutonism in the Northwestern Wilson Terrane, North Victoria Land and Oates Coast, Antarctica
N2 - No abstract available
KW - Wilson Terrane ; intrusions ; mafic composition ; relative age ; petrographic analysis ; gabbroic composition ; subduction zones
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31805
ER -
TY - JOUR
A1 - Engels, Bernd
T1 - Study of influences of various excitation classes on ab initio calculated isotropic hyperfine coupling constants
N2 - Reliable prediction of the isotropic hyperfine coupling constant A\(_{iso}\) is still a difficult task for ab initio calculations. Strang dependence on the method employed for its ca1culation has been found. Within a CI ansatz A\(_{iso}\) is considerably affected by the excitation classes taken into account within the CI calculation. In the present work the influence of various excitation classes on A\(_{iso}\) is examined. Calculations including all single, double, triple and a large part of the quadruple excitations are performed and the individual effects of the excitation classes are studied. It is found that the surprisingly good agreement found for S-CI treatments is due to large error cancellations. The importance of higher than double excitations arises from their indirect influence on the single excitations.
KW - Organische Chemie
KW - Spin density
KW - Hyperfine coupling constants
KW - Influence of excitation classes
KW - Indirect and direct contributions to Aiso
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58973
ER -
TY - JOUR
A1 - Berger, Susanne
A1 - Ellersiek, Ulrike
A1 - Westhoff, Peter
A1 - Steinmüller, Klaus
T1 - Studies on the expression of NDH-H, a subunit of the NAD(P)H-plastoquinone-oxidoreductase of higher-plant chloroplasts
N2 - The plastid genomes of higher plants contain eleven reading frames (ndhA-K) that are homologous to genes encoding subunits of the mitochondrial NADH-ubiquinone-oxidoreductase (complex I). The carboxyterminal end of the NDH-H subunit from rice (Oryza sativa L.) was expressed as a fusion protein in Escherichia coli and antibodies against the fusion protein were generated in rabbits. The antibody was used to study the expression of NDH-H, and the following results were obtained: (i) NDH-H is expressed in mono- and dicotyledonous plants, (ii) NDH-H is localized on the stroma lamellae of the thylakoid membrane and (iii) NDH-H is expressed in etioplasts. Together with the finding that two other ndh genes (ndhI and ndhK) are expressed in plastids, these results point to the existence of an NAD(P)H-plastoquinone-oxidoreductase on the thylakoid membrane. The possible function of the enzyme in plastids is discussed and it is suggested that it works in balancing the ATP/ADP and the NADPH/NADP ratios during changing external (i.e. light) or internal (i.e. ATP and NADPH demands of biosynthetic pathways of the plastid) conditions.
KW - NAD(P)H-plastoquinone-oxidoreductase
KW - ndhH gene
KW - Plastid DNA
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31283
ER -
TY - JOUR
A1 - Scheer, Ulrich
A1 - Thiry, Marc
A1 - Goessens, Guy
T1 - Structure, function and assembly of the nucleolus
N2 - No abstract available
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-32057
ER -
TY - JOUR
A1 - Schneider-Schaulies, Sibylle
A1 - Schneider-Schaulies, Jürgen
A1 - Bayer, M.
A1 - Löffler, S.
A1 - ter Meulen, V.
T1 - Spontaneous and differentiation dependent regulation of measles virus gene expression in human glial cells
N2 - The expression of measles virus (MV) in six different permanent human glioma cell lines (D-54, U-251, U-138, U-105, U-373, and D-32) was analyzed. Although all celllines were permissive for productive replication of all MV strains tested, U-251, D-54, and D-32 cells spontaneously revealed restrictions of MV transcription similar to those observed for primary rat astroglial cells and brain tissue. In vitro differentiation of D-54 and U-251 cells by substances affecting tbe intracellular cyclic AMP Ievel caused a significant reduction of tbe expression of tbe viral proteins after 18, 72, and 144 b of infection. This pronounced restriction was not paralleled to a comparable Ievel by an inhibition of tbe syntbesis and biological activity in vitro of virus·specific mRNAs as sbown by quantitative Northem (RNA) blot analyses and in vitro translation. The block in viral protein syntbesis could not be attributed to tbe induction of type I interferon by any of tbe substances tested. Our findings indicate tbat down-regulation of MV gene expression in human brain cells can occur by a cell type-rlependent regulation of tbe viral mRNA transcription and a differentiation-dependent regulation of translation, botb of wbicb may be crucial for the establisbment of persistent MV infections in tbe centrat nervous system.
KW - Immunologie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54913
ER -
TY - JOUR
A1 - Bentley, T. W.
A1 - Norman, S. J.
A1 - Gerstner, E.
A1 - Kemmer, R.
A1 - Christl, Manfred
T1 - Solvolysis of Tricyclo[3.1.0.0\(^{2,6}\)]hex-3-yl and Bicyclo[2.1.1]hex-2-yl Sulfonates
N2 - No abstract available
KW - Organische Chemie
KW - Bicyclo[1.1.0]butylcarbinyl sulfonates
KW - solvolysis of
KW - Cyclobutylcarbinyl sulfonates
KW - Anchimeric assistance in solvolysis
KW - Rearrangement of carbocations
KW - Electron demand in ditosylates
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58689
ER -
TY - JOUR
A1 - Weyers, P.
A1 - Janke, W.
A1 - Macht, Michael
A1 - Weijers, H.-G.
T1 - Social and nonsocial open field behaviour of rats under light and noise stimulation
N2 - ln two experiments, male rats were observed in pairs under different environmental stimulations in an open field. ln Experiment 1, white noise of 85 dB(A) reduced social activities and increased defecation compared to 75 dB(A) and 65 dß(A). ln Experiment 2, the illumination of the open field was varied in addition to a variation of the noise intensity. Again, 85 dB(A) as compared to 50 dB(A) reduced social activities and increased defecation, but also led to changes in non-social behaviours such as sniffing, grooming, and rearing. ln contrast, 400 lx did not differ substantially in its effects from 40 lx in any of the observed behavioural categories. Altogether, the behaviour pattern under 85 dß(A) white noise cannot satisfactorily be explained only by increased anxiety or fear. Alternative explanations are discussed.
KW - Psychologie
KW - Social activity
KW - Stress
KW - Light stimulation
KW - Noise stimulation
KW - Environment
KW - open field behaviour
KW - Emotionality
KW - Rat
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61246
ER -
TY - JOUR
A1 - Tafler, R.
A1 - Herbert, M. K.
A1 - Schmidt, R. F.
A1 - Weis, K. H.
T1 - Small reduction of capsaicin-induced neurogenic inflammation in human forearm skin by the glucocorticoid prednicarbate
JF - Agents Actions
N2 - No abstract available.
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-127698
VL - 38
IS - Special Conference Issue
ER -
TY - JOUR
A1 - Gillitzer, Reinhard
A1 - Moll, Heidrun
T1 - Simultaneous demonstration of two antigens with immunogold-silver staining and immunoenzymatic labeling
N2 - A novel technique for independent and simultaneous labeling of two antigens expressed on individual cells (referred to as mixed labeling) is presented. The staining procedure combined three-step (streptavidin-biotin) immunogold-silver staining with three-step immunoenzymatic labeling. To ensure both high specificity and high sensitivity, particular emphasis was placed on designing a protocol that avoids immunological crossreactivity between the antibody reagents and overlapping of the final color products. Two examples for usage of this mixed labeling technique are described: lymphocyte subpopulations were identified in inflammatory lesions of human skin and infected host cells were characterized in the skin of mice infected with the obligatory intracellular parasite Leishmania major, a cause of human cutaneous leishmaniasis.
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33019
ER -
TY - JOUR
A1 - Banach, Katrin
A1 - Bünemann, Moritz
A1 - Hüser, Jörg
A1 - Pott, Lutz
T1 - Serum contains a potent factor that decreases \(\beta\)-adrenergic receptor-stimulated L-type Ca\(^{2+}\) current in cardiac myocytes
N2 - No abstract available
KW - Cardiac myocyte ; Beta-Receptor ; Muscarinic receptor ; cAMP ; G-protein ; Serum
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-32027
ER -
TY - CHAP
A1 - Zillober, Christian
T1 - Sequential convex programming in theory and praxis
N2 - In this paper, convex approximation methods, suclt as CONLIN, the method of moving asymptotes (MMA) and a stabilized version of MMA (Sequential Convex Programming), are discussed with respect to their convergence behaviour. In an extensive numerical study they are :finally compared with other well-known optimization methods at 72 examples of sizing problems.
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-35513
ER -
TY - JOUR
A1 - Gessler, Manfred
A1 - Bruns, Gail A.
T1 - Sequence of the WT1 upstream region including the Wit-1 gene
N2 - No abstract available
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30193
ER -
TY - JOUR
A1 - Hong, Yunhan
A1 - Schartl, Manfred
T1 - Sequence of the growth hormone (GH) gene from the silver carp (Hypophthalmichthys molitrix) and evolution of GH genes in vertebrates
N2 - The silver carp (Hypophthalmichthys molitrix) growth hormone (GH) genewas isolated and sequenced following amplification from genomic DNA by the polymerase chain reaction. The gene spans a region of approx. 2.5 kb nucleotides (nt) and consists of five exons. The sequence predicts a polypeptide of 210 amino acids (aa) including a putative signal peptide of 22 hydrophobic aa residues. The arrangement of exons and introns is identical to the GH genes of common carp, grass carp, and very similar to mammals and birds, but quite different from that for the GH genes of tilapia and salmonids. The silver carp GH gene shares a high homology at the nt and aa Ievels with those of grass carp (95.3% nt, 99.5% aa) and of common carp (81% nt, 95.7% aa).
KW - Physiologische Chemie
KW - Recombinant DNA ; Growth hormone gene ; PCR; Silver carp ; Fish
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61620
ER -
TY - JOUR
A1 - Stöber, Gerald
A1 - Franzek, E.
A1 - Beckmann, H.
T1 - Schwangerschafts- und Geburtskomplikationen - ihr Stellenwert in der Entstehung schizophrener Psychosen
N2 - In a retrospective study of 80 chronic DSM 111-R schizophrenics and 80 controls, the occurrence of obstetric complications (OCs) into the development of chronic schizophrenias was investigated using Leonhard s distinction in systematic schizophrenia (no obvious familial loading) and unsystematic schizophrenia (mainly genetically determined according to Leonhard). The Lewis & Murray and Fuchs scales were used for evaluation. In both scales, unsystematic schizophrenias did not differ from controls, but those with OCs were significantly (p < 0.01) earlier hospitalized (20.5 years) than those without OCs (25.6 years). Systematic schizophrenics had an increased frequency, severity and total score of OCs compared to controls in the Fuchs scale (p < 0.0 I). Likewise, in the Lewis & Murray scale systematic schizophrenia showed an increased presence ofOCs compared to controls (p < 0.05) and to unsystematic schizophrenia (p < 0.1 ). Systematic schizophrenias were significantly allocated to matemal infectious diseases during mid-gestation. Patients with matemal infections showed moreadditional OCs than those without (p < 0.05; Lewis & Murray scale). In systematic schizophrenia, a history of OC was not associated with an early onset of the disease. In the genetic determined schizophrenias prenatal and perinatal disturbanccs Iead to an early onset of the disease, however, in systematic schizophrenias they seem to be of causal importance for the development of the disease.
N2 - Auf der Grundlage von Leonhards Unterteilung in systematische Schizophrenien (niedriges genetisches Risiko) und unsystematische Schizophrenien (nach Leonhardr Befunden hauptsächlich genetisch determiniert) wurden in einer retrospektiven Studie bei 80 Patienten mit chronischen DSM 111-R Schizophrenien und 80 Kontrollen die Häufigkeit von Schwangerschafts- und Geburtskomplikationen untersucht. Zur Auswertung wurden die Skalen von Lewis & Murray sowie von Fuchs verwandt. Unsystematische Schizophrenien unterschieden sich in beiden Skalen nicht von den Kontrollen. Diejenigen mit Komplikationen wurden jedoch signifikant früher als diejenigen ohne Komplikationen ersthospitalisiert (p < 0,01 ). Bei systematischen Schizophrenen waren in ; der Skala von Fuchs Häufigkeit, Schweregrad sowie der Summenwert der Komplikationen gegenüber den Kontrollen erhöht (p < 0,0 I). Auch in der Skala von Lewis & Murray traten häufiger obstetrische Komplikationen auf als bei Kontrollen (p < 0,05) und unsystematischen Schizophrenen (p < 0,1 ). Systematische Schizophrenien waren auch assoziiert mit Schwangerschaftsinfektionen im zweiten Trimenon. Mütter mit Schwangerschaftsinfektionen zeigten gehäuft weitere perinatala Komplikationen (p < 0,05). Geburtskomplikationen hatten bei systematischen Schizophrenen jedoch keinen Einfluß auf den Zeitpunkt des Krankheitsbeginns. Während pdi und perinatale Störungen bei genetisch determinierten Schizophrenien lediglich einen frühen Krankheitsbeginn bewirken, scheinen sie bei den systematischen Schizophrenien von ursächlicher Bedeutung fiir die Krankheitsentstehung zu sein.
KW - Schwangerschaft
KW - Schizophrenie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63343
ER -
TY - JOUR
A1 - Shanjia, Xu
A1 - Xinzhang, Wu
A1 - Boege, P.
A1 - Schäfer, H.
A1 - Becker, Charles R.
A1 - Geick, R.
T1 - Scattering characteristics of 3-D discontinuity consisting of semiconductor sample filled in waveguide with gaps
N2 - No abstract available
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37964
ER -
TY - JOUR
A1 - Paakkari, P.
A1 - Paakkari, I.
A1 - Landes, P.
A1 - Sirén, Anna-Leena
A1 - Feuerstein, G.
T1 - Respiratory \(\mu\)-Opioid and benzodiazepine interactions in the understrained rat
N2 - lnteractions of p-opioid receptors with the benzodiazepine system were studied by examining the modulatory effects of flumazenil (a benzodiazepine antagonist) and alprazolam (a benzodiazepine agonist) on the respiratory effects ofthe opioid peptide dermorphin. Dermorphin, 1-30 nmol administered i.c.v., to conscious, unrestrained rats decreased ventilation rate (VR) and minute volume (MV) dose-dependently. The ventilatory depression was antagonized by naloxone and by the benzodiazepine antagonist flumazenil. The benzodiazepine alprazolam potentiateri the respiratory inhibition of a small (I nmol) dose of dermorphin but antagonized that of a higher dos:~ (3 nmol). The results suggest that the benzodiazepine/GABA receptor complex modulates respiratory depression induced by centrat p-receptor Stimulation in the rat.
KW - Neurobiologie
KW - dermorphin
KW - opioid receptors
KW - opioid-benzodiazepine interactions
KW - respiration
KW - flumazenil
KW - benzodiazepine antagonist.
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62974
ER -
TY - JOUR
A1 - Schartl, Manfred
A1 - Erbelding-Denk, Claudia
A1 - Holter, Sabine
A1 - Nanda, Indrajit
A1 - Schmid, Michael
A1 - Schroder, Johannes H.
A1 - Epplen, Jörg T.
T1 - Reproductive failure of dominant males in the poeciliid fish Limia perugiae determined by DNA fingerprinting
N2 - Hierarchical structures among male indlviduals in a population are frequently reflected ln differences in aggressive and reproductive behavior and access to the females. In general, sodal dominance requires the Investments, which in turn then may have to be compensated for by high reproductive success. However, this hypothesls has so far only been sufficiently tested in small mating groups (one or two males with one or two females) due to the difficulties of determining paternity by conventional methods. DNA fingerprinting overcomes these problems by offering the possibility to determine genetic relationships and mating patterns within larger groups [Borke, T. (1989) Trends Ecol. Evol. 4, 139-144]. We show here that in the poecUiid fish Limia perugitu, in small matlng groups the dominant male has 8 mating success of 100%, whereas ln larger groups lts contribution to the offspring unexpectedly drops to zero.
KW - Physiologische Chemie
KW - reproductive success
KW - sexual selection
KW - size polymorpbism
KW - sodal domlnance
KW - simple repetitive sequences
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61643
ER -
TY - JOUR
A1 - Adami, Hans-Olov
A1 - Dragsted, Lars
A1 - Enig, Bent
A1 - Hansen, Jens
A1 - Haraldsdóttir, Jóhanna
A1 - Hill, Michael J.
A1 - Holm, Lars Erik
A1 - Knudsen, Ib
A1 - Larsen, Jens-Jorgen
A1 - Lutz, Werner K.
A1 - Osler, Merete
A1 - Overvad, Kim
A1 - Sabroe, Svend
A1 - Sanner, Tore
A1 - Strube, Michael
A1 - Sorensen, Thorkild I. A.
A1 - Thorling, Eivind B.
T1 - Report from the working group on diet and cancer.
N2 - No abstract available.
KW - Krebs
KW - Ernährung
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-71601
ER -
TY - JOUR
A1 - Wu, Y. S.
A1 - Becker, Charles R.
A1 - Waag, A.
A1 - Bicknell-Tassius, R. N.
A1 - Landwehr, G.
T1 - Removal of oxygen and reduction of carbon contamination on (100) Cd\(_{0.96}\)Zn\(_{0.04}\)Te
N2 - No abstract available
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38014
ER -
TY - JOUR
A1 - Morschhäuser, Joachim
A1 - Vetter, Viktoria
A1 - Korhonen, Timo
A1 - Uhlin, Bernt Eric
A1 - Hacker, Jörg
T1 - Regulation and binding properties of S fimbriae cloned from E. coli strains causing urinary tract infection and meningitis
N2 - S fimbriae are able to recognize receptor molecules containing sialic acid and are produced by pathogenic E. coli strains causing urinary tract infection and menigitis. In order to characterize the corresponding genetic determinant, termed S fimbrial adhesin ( sfa) gene duster, we have cloned the S-specific genes from a urinary pathogen and from a meningitis isolate. Nine genes are involved in the production of S fimbriae, two of these, sfaB and sfaC code for regulatory proteins being necessary for the expression of S fimbriae. Two promoters, PB and Pc, are located in front of these genes. Transcription of the sfa determinant is influenced by activation of the promotersvia SfaB and SfaC, the action of the H-NS protein and an RNaseE-specific mRNA processing. In addition, a third promoter, P A• located in front of the major subunit gene sfaA, can be activated under special circumstances. Four genes of the sfa determinant code for the subunit-specific proteins, SfaA (16 kda), SfaG (17 kda), SfaS (14 kda) and SfaH (29 kda). It was demonstrated that the protein SfaA is the major subunit protein while SfaS is identical to the sialic-acid-specific adhesin of S fimbriae. The introduction of specific mutations into sfaS revealed that a region of six amino acids of the adhesin which includes two lysine and one arginine residues is involved in the receptor specific interaction of S fimbriae. Additionally, it has been shown that SfaS is necessary for the induction of fimbriation while SfaH plays a role in the stringency of binding of S fimbriae to erythrocytes.
KW - Escherichia coli
KW - Harnwegsinfekt
KW - Hirnhautentzündung
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86140
ER -
TY - JOUR
A1 - Carroll, Patrick
A1 - Sendtner, Michael
A1 - Meyer, Michael
A1 - Thoenen, Hans
T1 - Rat ciliary neurothrophic factor (CNTF): gene structure and regulation of mRNA levels in glial cell cultures.
N2 - The structure of the rat ciliary neurotrophic factor (CNTF) gene and the regulation ofCNTF mRNA levels in cultured glial cells were investigated. The rat mRNA is encoded by a simple two-exon transcription unit. Sequence analysis of the region upstream of the transcription start-site did not reveal a typical TATA-box consensus sequence. Low levels of CNTF mRNA were detected in cultured Schwann cells, and CNTF mRNA was not increased by a variety of treatments. Three-week-old astrocyteenriched cell cultures from new-born rat brain contained easily detectable CNTF mRNA. In astrocyte-enriched cultures, upregulation of CNTF mRNA levels was observed after treatment with IFN-gamma. CNTF mRNA levels were down-regulated in these cells by treatments that elevate intracellular cyclic AMP and by members of the fibroblast growth factor (FGF) family. The implications of these results for potential in vivo functions of CNTF are discussed.
KW - Astrocytes ; Schwann cells ; Interferon-gamma ; Fibroblast growth factor ; Cyclic AMP
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31763
ER -
TY - GEN
A1 - Macht, Michael
T1 - Psychophysiological effects of a short-term reduction of energy supply
N2 - No abstract available
KW - Psychologie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-55269
ER -
TY - CHAP
A1 - Hedke, K.
A1 - Eckstein, V.
A1 - May, G.
A1 - Kaden, J.
A1 - Müller-Ruchholtz, W.
A1 - Ulrichs, Karin
T1 - Production of Xenophile Antibodies (XA) in Type I Diabetic Patients is Strongly Influenced by Diabetes and/or Dialysis
N2 - No abstract available
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45642
ER -
TY - JOUR
A1 - Archelos, JJ
A1 - Roggenbuck, K.
A1 - Schneider-Schaulies, Jürgen
A1 - Linington, C.
A1 - Toyka, KV
A1 - Hartung, H.-P.
T1 - Production and characterization of monoclonal antibodies to the extracellular domain of PO
N2 - Seven monoclonal antibodies were raised against the immunoglobulin-like extracellular domain of PO (POED), the major protein of peripheral nervous system myelin. Mice were immunized with purified recombinant rat PO-ED. After fusion, 7 clones (POI-P07) recognizing either recombinant, rat, mouse, or human PO-ED were selected by ELlS A and were characterized by Western blot, immunohistochemistry, and a competition assay. Antibodies belonged to the IgG or IgM class, and P04-P07, reacted with PO in fresh-frozen and paraffin-embedded sections of human or rat peripheral nerve, but not with myelin proteins of the central nervous system of either species. Epitope specificity of the antibodies was determined by a competition enzyme-linked immunosorbent assay (ELISA) and a direct ELlS A using short synthetic peptides spanning the entire extracellular domain of PO. These assays showed that POl and P02 exhibiting the same reaction pattern in Western blot and immunohistochemistry reacted with different distant epitopes of PO. Furthermore, the monoclonal antibodies P05 and P06 recognized 2 different epitopes in close proximity within the neuritogenic extracellular sequence of PO. This panel of monoclonal antibodies, each binding to a different epitope of the extracellular domain of PO, will be useful for in vitro and in vivo studies designed to explore the role of PO during myelination and in demyelinating diseases of the peripheral nervous system.
KW - Immunologie
KW - peripheral nervous system
KW - myelin
KW - epitope specificity
KW - demyelination
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54889
ER -
TY - JOUR
A1 - Nanda, Indrajit
A1 - Schartl, Manfred
A1 - Epplen, Jörg T.
A1 - Feichtinger, Wolfgang
A1 - Schmid, Michael
T1 - Primitive sex chromosomes in poeciliid fishes harbor simple repetitive DNA sequences
N2 - The demonstration ofthe chromosomal mode ofsex determinationvia genetic experiments as well as the absence of heteromorphic sex chromosomes affirm poeciliid fishes as a unique group among vertebrates that are endowed with the mostprimitive form of sex chromosornes. In many different taxa the evolutionary process involved in the differentiation ofadvanced sex chromosomes is outlined through sex specifically organized repetitive sequences. In this investigation hydridization of synthetic probes specific to genomic simple repeat motifs uncovers a sex-specific hybridization pattern in certain viviparaus fishes ofthe family Poeciliidae. The hybridization pattern together with specific staining ofthe constitutive heterochromatin by C-banding reveals heterogamety in males (Poecilia reticulata) as weil as in females (P. sphenops). In P. velifera, however, C-banding alone fails to unravel the heterogametic status. The female specific W-chromosome can be detected by simple repetitive sequence probes. Therefore, the principal significance of heterochromatization as a means of generating differentiated sex chromosomes is evident.
KW - Physiologische Chemie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61659
ER -
TY - JOUR
A1 - Sirén, Anna-Leena
A1 - McCarron, R. M.
A1 - Liu, Y.
A1 - Barone, F.
A1 - Spatz, M.
A1 - Feuerstein, G.
A1 - Hallenbeck, J. M.
T1 - Perivascular monocyte/macrophage interaction with endothelium as a mechanism through which stroke-risk factors operate to increase stroke likelihood. Research Initiatives in Vascular Disease; SPECIAL COMMUNICATION
N2 - No abstract available
KW - Neurobiologie
Y1 - 1993
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63006
ER -