TY  - JOUR
A1  - Luxenhofer, Robert
A1  - Fetsch, Corinna
T1  - Thermal Properties of Aliphatic Polypeptoids
JF  - Polymers
N2  - A series of polypeptoid homopolymers bearing short (C1–C5) side chains of degrees of polymerization of 10–100 are studied with respect to thermal stability, glass transition and melting points. Thermogravimetric analysis of polypeptoids suggests stability to >200 °C. The study of the glass transition temperatures by differential scanning calorimetry revealed two dependencies. On the one hand an extension of the side chain by constant degree of polymerization decrease the glass transition temperatures (Tg) and on the other hand a raise of the degree of polymerization by constant side chain length leads to an increase of the Tg to a constant value. Melting points were observed for polypeptoids with a side chain comprising not less than three methyl carbon atoms. X-ray diffraction of polysarcosine and poly(N-ethylglycine) corroborates the observed lack of melting points and thus, their amorphous nature. Diffractograms of the other investigated polypeptoids imply that crystalline domains exist in the polymer powder.
KW  - peptoid
KW  - biomaterials
KW  - glass transition temperature
KW  - DSC
KW  - TGA
KW  - XRD
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-96333
ER  - 
TY  - JOUR
A1  - Fetsch, Corinna
A1  - Gaitzsch, Jens
A1  - Messager, Lea
A1  - Battaglia, Giuseppe
A1  - Luxenhofer, Roberts
T1  - Self-Assembly of Amphiphilic Block Copolypeptoids – Micelles, Worms and Polymersomes
JF  - Scientific Reports
N2  - Polypeptoids are an old but recently rediscovered polymer class with interesting synthetic, physico-chemical and biological characteristics. Here, we introduce new aromatic monomers, N-benzyl glycine N-carboxyanhydride and N-phenethyl glycine N-carboxyanhydride and their block copolymers with the hydrophilic polysarcosine. We compare their self-assembly in water and aqueous buffer with the self-assembly of amphiphilic block copolypeptoids with aliphatic side chains. The aggregates in water were investigated by dynamic light scattering and electron microscopy. We found a variety of morphologies, which were influenced by the polymer structure as well as by the preparation method. Overall, we found polymersomes, worm-like micelles and oligo-lamellar morphologies as well as some less defined aggregates of interconnected worms and vesicles. Such, this contribution may serve as a starting point for a more detailed investigation of the self-assembly behavior of the rich class of polypeptoids and for a better understanding between the differences in the aggregation behavior of non-uniform polypeptoids and uniform peptoids.
KW  - bioinspired materials
KW  - polymer characterization
KW  - polymer synthesis
KW  - polymers
KW  - self-assembly
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-147855
VL  - 6
ER  -