TY  - JOUR
A1  - Woźnicki, Piotr
A1  - Laqua, Fabian Christopher
A1  - Messmer, Katharina
A1  - Kunz, Wolfgang Gerhard
A1  - Stief, Christian
A1  - Nörenberg, Dominik
A1  - Schreier, Andrea
A1  - Wójcik, Jan
A1  - Ruebenthaler, Johannes
A1  - Ingrisch, Michael
A1  - Ricke, Jens
A1  - Buchner, Alexander
A1  - Schulz, Gerald Bastian
A1  - Gresser, Eva
T1  - Radiomics for the prediction of overall survival in patients with bladder cancer prior to radical cystectomy
JF  - Cancers
N2  - (1) Background: To evaluate radiomics features as well as a combined model with clinical parameters for predicting overall survival in patients with bladder cancer (BCa). (2) Methods: This retrospective study included 301 BCa patients who received radical cystectomy (RC) and pelvic lymphadenectomy. Radiomics features were extracted from the regions of the primary tumor and pelvic lymph nodes as well as the peritumoral regions in preoperative CT scans. Cross-validation was performed in the training cohort, and a Cox regression model with an elastic net penalty was trained using radiomics features and clinical parameters. The models were evaluated with the time-dependent area under the ROC curve (AUC), Brier score and calibration curves. (3) Results: The median follow-up time was 56 months (95% CI: 48–74 months). In the follow-up period from 1 to 7 years after RC, radiomics models achieved comparable predictive performance to validated clinical parameters with an integrated AUC of 0.771 (95% CI: 0.657–0.869) compared to an integrated AUC of 0.761 (95% CI: 0.617–0.874) for the prediction of overall survival (p = 0.98). A combined clinical and radiomics model stratified patients into high-risk and low-risk groups with significantly different overall survival (p < 0.001). (4) Conclusions: Radiomics features based on preoperative CT scans have prognostic value in predicting overall survival before RC. Therefore, radiomics may guide early clinical decision-making.
KW  - bladder cancer
KW  - radical cystectomy
KW  - radiomics
KW  - outcome prediction
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-288098
SN  - 2072-6694
VL  - 14
IS  - 18
ER  -