TY  - JOUR
A1  - Kerkau, Thomas
A1  - Schmitt-Landgraf, Renate
A1  - Schimpl, Anneliese
A1  - Wecker, Eberhard
T1  - Downregulation of HLA Class I Antigensin HIV-1-Infected Cells
N2  - By means of indirect immunofluorescence analysis we investigated the effect of HIV -1 infection on HLA class I surface antigens. We report here that in CD4\(^+\) HeLa cells, in H9 cells, and in peripheral T Iymphocytes HLA class I antigens are down regulated following infection with HIV -1. The downregulation is effected at a posttranscriptional level since the amounts of HLA class I specific mRNA are similar in infected and uninfected cells. This phenomenon is not only correlated with the state of infection, that is, the presence of P24 of HIV-l in the cells, but also depends on the time of infection. Upon HLA class I downregulation by HIV infection, the specific lysis of peripheral blood cells by allogeneic CTL is reduced.
Y1  - 1989
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47172
ER  -