TY  - JOUR
A1  - Macedo, Robson
A1  - Javadi, Som Mehrbod
A1  - Higuchi, Takahiro
A1  - Ferreira de Carvalho, Marilia Daniela
A1  - Lima Paiva Medeiros, Vanessa de Fátima
A1  - Azevedo, Ítalo Medeiros
A1  - Lima, Francisco Pignataro
A1  - Medeiros, Aldo Cunha
T1  - Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc\(^{99m}\)-sestamibi biodistribition
JF  - Acta Cirúrgica Brasileira
N2  - PURPOSE: 
To evaluate the heart and the Tc-99m-sestamibi biodistribution after statin pretreatment in a rat model of abdominal sepsis. 

METHODS: 
Twenty-four Wistar rats were randomly distributed into four groups (n=6 per group): 1) sepsis with simvastatin treatment, 2) sepsis with vehicle, 3) sham control with simvastatin and 4) sham control with vehicle. 24 hours after cecal ligation and puncture rats received 1.0MBq of Tc-99m-sestamibi i.v. 30min after, animals were euthanized for ex-vivo tissue counting and myocardium histological analysis. 

RESULTS: 
Myocardial histologic alterations were not detected 24 hours post-sepsis. There was significantly increased cardiac Tc-99m-sestamibi activity in the sepsis group with simvastatin treatment (1.9\(\pm\)0.3%ID/g, p<0.001) in comparison to the sepsis group+vehicle (1.0\(\pm\)0.2% ID/g), control sham group+ simvastatin (1.2\(\pm\)0.3% ID/g) and control sham group (1.3\(\pm\)0.2% ID/g). Significant Tc-99m-sestamibi activity in liver, kidney and lungs was also detected in the sepsis group treated with simvastatinin comparison to the other groups. 

CONCLUSIONS: 
Statin treatment altered the biodistribution of Tc-99m-sestamibi with increased cardiac and solid organ activity in rats with abdominal sepsis, while no impact on controls. Increased myocardial tracer activity may be a result of a possible protection effect due to increased tissue perfusion mediated by statins.
KW  - P-glycoprotein expression
KW  - mechanisms retention
KW  - Simvastatin
KW  - Technetium Tc 99m Sestamibi Rats
KW  - heart
KW  - inflammation
KW  - sepsis
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-151887
VL  - 30
IS  - 6
SP  - 388
EP  - 393
ER  -