TY  - JOUR
A1  - Herrmann, Thomas
A1  - Karunakaran, Mohindar M.
T1  - Butyrophilins: γδ T cell receptor ligands, immunomodulators and more
JF  - Frontiers in Immunology
N2  - Butyrophilins (BTN) are relatives of the B7 family (e.g., CD80, PD-L1). They fulfill a wide range of functions including immunomodulation and bind to various receptors such as the γδ T cell receptor (γδTCR) and small molecules. One intensively studied molecule is BTN3A1, which binds via its cytoplasmic B30.2 domain, metabolites of isoprenoid synthesis, designated as phosphoantigen (PAg), The enrichment of PAgs in tumors or infected cells is sensed by Vγ9Vδ2 T cells, leading to the proliferation and execution of effector functions to remove these cells. This article discusses the contribution of BTNs, the related BTNL molecules and SKINT1 to the development, activation, and homeostasis of γδ T cells and their immunomodulatory potential, which makes them interesting targets for therapeutic intervention.
KW  - butyrophilin
KW  - immune therapy
KW  - T cell receptor
KW  - γδ T cell
KW  - BTN3A1
KW  - BTN2A1
KW  - phosphoantigen
KW  - tumor
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-265944
SN  - 1664-3224
VL  - 13
ER  -