TY  - JOUR
A1  - Berger, Constantin
A1  - Zdzieblo, Daniela
T1  - Glucose transporters in pancreatic islets
JF  - Pflügers Archiv - European Journal of Physiology
N2  - The fine-tuning of glucose uptake mechanisms is rendered by various glucose transporters with distinct transportcharacteristics. In the pancreatic islet, facilitative diffusion glucose transporters (GLUTs), and sodium-glucosecotransporters (SGLTs) contribute to glucose uptake and represent important components in the glucose-stimulatedhormone release from endocrine cells, therefore playing a crucial role in blood glucose homeostasis. This reviewsummarizes the current knowledge aboutcell type-specific expression profiles as well as proven and putative functionsof distinct GLUT and SGLT family members in the human and rodent pancreatic islet and further discusses their possibleinvolvement in onset and progression ofdiabetes mellitus. In context of GLUTs, we focus on GLUT2, characterizing themain glucose transporter in insulin-secretingβ-cells in rodents. In addition, we discuss recent data proposing that otherGLUT family members, namely GLUT1 and GLUT3, render this task in humans. Finally, we summarize latest infor-mation about SGLT1 and SGLT2 as representatives of the SGLT family that have been reported to be expressed predominantly in the α-cell population with a suggested functional role in the regulation of glucagon release
KW  - Glucose transport
KW  - Pancreatic islet
KW  - β-Cell
KW  - α-Cell
KW  - GLUTs
KW  - SGLTs
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-232738
SN  - 0031-6768
VL  - 472
ER  -