TY  - JOUR
A1  - Wirtz, Dieter C.
A1  - Gravius, Sascha
A1  - Ascherl, Rudolf
A1  - Thorweihe, Miguel
A1  - Forst, Raimund
A1  - Noeth, Ulrich
A1  - Maus, Uwe M.
A1  - Wimmer, Matthias D.
A1  - Zeiler, Guenther
A1  - Deml, Moritz C.
T1  - Uncemented femoral revision arthroplasty using a modular tapered, fluted titanium stem 5-to 16-year results of 163 cases
JF  - Acta Orthopaedica
N2  - Background and purpose - Due to the relative lack of reports on the medium- to long-term clinical and radiographic results of modular femoral cementless revision, we conducted this study to evaluate the medium- to long-term results of uncemented femoral stem revisions using the modular MRP-TITAN stem with distal diaphyseal fixation in a consecutive patient series. 
Patients and methods - We retrospectively analyzed 163 femoral stem revisions performed between 1993 and 2001 with a mean follow-up of 10 (5-16) years. Clinical assessment included the Harris hip score (HHS) with reference to comorbidities and femoral defect sizes classified by Charnley and Paprosky. Intraoperative and postoperative complications were analyzed and the failure rate of the MRP stem for any reason was examined. 
Results - Mean HHS improved up to the last follow-up (37 (SD 24) vs. 79 (SD 19); p < 0.001). 99 cases (61%) had extensive bone defects (Paprosky IIB-III). Radiographic evaluation showed stable stem anchorage in 151 cases (93%) at the last follow-up. 10 implants (6%) failed for various reasons. Neither a breakage of a stem nor loosening of the morse taper junction was recorded. Kaplan-Meier survival analysis revealed a 10-year survival probability of 97% (95% CI: 95-100). 
Interpretation - This is one of the largest medium- to longterm analyses of cementless modular revision stems with distal diaphyseal anchorage. The modular MRP-TITAN was reliable, with a Kaplan-Meier survival probability of 97% at 10 years.
KW  - follow-up
KW  - distal fixation
KW  - bone loss
KW  - replacement
KW  - register
KW  - junction
KW  - cement
KW  - prosthesis
KW  - roentgenographic assessment
KW  - total HIP-arthroplasty
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-114555
SN  - 1745-3674
VL  - 85
IS  - 6
ER  - 
TY  - JOUR
A1  - Kolominsky-Rabas, Peter L.
A1  - Wiedmann, Silke
A1  - Weingärtner, Michael
A1  - Liman, Thomas G.
A1  - Endres, Matthias
A1  - Schwab, Stefan
A1  - Buchfelder, Michael
A1  - Heuschmann, Peter U.
T1  - Time Trends in Incidence of Pathological and Etiological Stroke Subtypes during 16 Years: The Erlangen Stroke Project
JF  - Neuroepidemiology
N2  - Background: Population-based data, which continuously monitors time trends in stroke epidemiology are limited. We investigated the incidence of pathological and etiological stroke subtypes over a 16 year time period. Methods: Data were collected within the Erlangen Stroke Project (ESPro), a prospective, population-based stroke register in Germany covering a total study population of 105,164 inhabitants (2010). Etiology of ischemic stroke was classified according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. Results: Between January 1995 and December 2010, 3,243 patients with first-ever stroke were documented. The median age was 75 and 55% were females. The total stroke incidence decreased over the 16 year study period in men (Incidence Rate Ratio 1995-1996 vs. 2009-2010 (IRR) 0.78; 95% CI 0.58-0.90) but not in women. Among stroke subtypes, a decrease in ischemic stroke incidence (IRR 0.73; 95% CI 0.57-0.93) and of large artery atherosclerotic stroke (IRR 0.27; 95% CI 0.12-0.59) was found in men and an increase of stroke due to small artery occlusion in women (IRR 2.33; 95% CI 1.39-3.90). Conclusions: Variations in time trends of pathological and etiological stroke subtypes were found between men and women that might be linked to gender differences in the development of major vascular risk factors in the study population.
KW  - stroke
KW  - epidemiology
KW  - incidence
KW  - time trends
KW  - register
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196503
SN  - 0251-5350
SN  - 1423-0208
N1  - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
VL  - 44
IS  - 1
ER  -