TY  - JOUR
A1  - Groß, Uwe
A1  - Amuzu, Sylvarius K.
A1  - de Ciman, Ring
A1  - Kassimova, Iparkhan
A1  - Groß, Lisa
A1  - Rabsch, Wolfgang
A1  - Rosenberg, Ulrike
A1  - Schulze, Marco
A1  - Stich, August
A1  - Zimmermann, Ortrud
T1  - Bacteremia and Antimicrobial Drug Resistance over Time, Ghana
JF  - Emerging Infectious Diseases
N2  - Bacterial distribution and antimicrobial drug resistance were monitored in patients with bacterial bloodstream infections in rural hospitals in Ghana. In 2001-2002 and in 2009, Salmonella enterica serovar Typhi was the most prevalent pathogen. Although most S. enterica serovar Typhi isolates were chloramphenicol resistant, all isolates tested were susceptible to ciprofloxacin.
KW  - Typhoid-fever
KW  - Children
KW  - Surveillance
KW  - Kenya
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-133805
N1  - All material published in Emerging Infectious Diseases is in the public domain and may be used and reprinted without special permission; proper citation, however, is required.
VL  - 17
IS  - 10
ER  - 
TY  - JOUR
A1  - Schmitt, Jana
A1  - Keller, Andreas
A1  - Nourkami-Tutdibi, Nasenien
A1  - Heisel, Sabrina
A1  - Habel, Nunja
A1  - Leidinger, Petra
A1  - Ludwig, Nicole
A1  - Gessler, Manfred
A1  - Graf, Norbert
A1  - Berthold, Frank
A1  - Lenhof, Hans-Peter
A1  - Meese, Eckart
T1  - Autoantibody Signature Differentiates Wilms Tumor Patients from Neuroblastoma Patients
JF  - PLoS ONE
N2  - Several studies report autoantibody signatures in cancer. The majority of these studies analyzed adult tumors and compared the seroreactivity pattern of tumor patients with the pattern in healthy controls. Here, we compared the autoimmune response in patients with neuroblastoma and patients with Wilms tumor representing two different childhood tumors. We were able to differentiate untreated neuroblastoma patients from untreated Wilms tumor patients with an accuracy of 86.8%, a sensitivity of 87.0% and a specificity of 86.7%. The separation of treated neuroblastoma patients from treated Wilms tumor patients' yielded comparable results with an accuracy of 83.8%. We furthermore identified the antigens that contribute most to the differentiation between both tumor types. The analysis of these antigens revealed that neuroblastoma was considerably more immunogenic than Wilms tumor. The reported antigens have not been found to be relevant for comparative analyses between other tumors and controls. In summary, neuroblastoma appears as a highly immunogenic tumor as demonstrated by the extended number of antigens that separate this tumor from Wilms tumor.
KW  - Heparan-sulfate
KW  - N-Myc
KW  - Serum autoantibodies
KW  - Suppressors EXT1
KW  - Neuro-blastoma
KW  - Allelic loss
KW  - Lung-cancer
KW  - Children
KW  - Amplification
KW  - Therapy
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-133794
VL  - 6
IS  - 12
ER  -