TY  - JOUR
A1  - Aktas, Bertal H.
A1  - Upcin, Berin
A1  - Henke, Erik
A1  - Padmasekar, Manju
A1  - Qin, Xuebin
A1  - Ergün, Süleyman
T1  - The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells
JF  - Stem Cells International
N2  - Pluripotent stem cells give rise to reproductively enabled offsprings by generating progressively lineage-restricted multipotent stem cells that would differentiate into lineage-committed stem and progenitor cells. These lineage-committed stem and progenitor cells give rise to all adult tissues and organs. Adult stem and progenitor cells are generated as part of the developmental program and play critical roles in tissue and organ maintenance and/or regeneration. The ability of pluripotent stem cells to self-renew, maintain pluripotency, and differentiate into a multicellular organism is highly dependent on sensing and integrating extracellular and extraorganismal cues. Proteins perform and integrate almost all cellular functions including signal transduction, regulation of gene expression, metabolism, and cell division and death. Therefore, maintenance of an appropriate mix of correctly folded proteins, a pristine proteome, is essential for proper stem cell function. The stem cells' proteome must be pristine because unfolded, misfolded, or otherwise damaged proteins would interfere with unlimited self-renewal, maintenance of pluripotency, differentiation into downstream lineages, and consequently with the development of properly functioning tissue and organs. Understanding how various stem cells generate and maintain a pristine proteome is therefore essential for exploiting their potential in regenerative medicine and possibly for the discovery of novel approaches for maintaining, propagating, and differentiating pluripotent, multipotent, and adult stem cells as well as induced pluripotent stem cells. In this review, we will summarize cellular networks used by various stem cells for generation and maintenance of a pristine proteome. We will also explore the coordination of these networks with one another and their integration with the gene regulatory and signaling networks.
KW  - Endoplasmic-Reticulum Stress
KW  - Heme-regulated inhibitor
KW  - Human Muse Cells
KW  - Transcription factor NRF1
KW  - ER-Stress
KW  - Hematopoietic Stem
KW  - Quality-control
KW  - Messenger-RNAs
KW  - Neural Differentiation
KW  - Translation Initiation
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227769
ER  -