TY  - JOUR
A1  - Naseem, Muhammad
A1  - Dandekar, Thomas
T1  - The Role of Auxin-Cytokinin Antagonism in Plant-Pathogen Interactions
JF  - PLOS Pathogens
N2  - No abstract available.
KW  - disease
KW  - pseudomas-syringae
KW  - arabidpsis thaliana
KW  - immunity
KW  - organogenesis
KW  - transcription
KW  - resistance
KW  - crosstalk
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-131901
VL  - 8
IS  - 11
ER  - 
TY  - JOUR
A1  - Morgenstern, Marcel
A1  - Peikert, Christian D.
A1  - Lübbert, Philipp
A1  - Suppanz, Ida
A1  - Klemm, Cinzia
A1  - Alka, Oliver
A1  - Steiert, Conny
A1  - Naumenko, Nataliia
A1  - Schendzielorz, Alexander
A1  - Melchionda, Laura
A1  - Mühlhäuser, Wignand W. D.
A1  - Knapp, Bettina
A1  - Busch, Jakob D.
A1  - Stiller, Sebastian B.
A1  - Dannenmaier, Stefan
A1  - Lindau, Caroline
A1  - Licheva, Mariya
A1  - Eickhorst, Christopher
A1  - Galbusera, Riccardo
A1  - Zerbes, Ralf M.
A1  - Ryan, Michael T.
A1  - Kraft, Claudine
A1  - Kozjak-Pavlovic, Vera
A1  - Drepper, Friedel
A1  - Dennerlein, Sven
A1  - Oeljeklaus, Silke
A1  - Pfanner, Nikolaus
A1  - Wiedemann, Nils
A1  - Warscheid, Bettina
T1  - Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context
JF  - Cell Metabolism
N2  - Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality control and have been linked to various diseases. Different views exist on the composition of the human mitochondrial proteome. We classified >8,000 proteins in mitochondrial preparations of human cells and defined a mitochondrial high-confidence proteome of >1,100 proteins (MitoCoP). We identified interactors of translocases, respiratory chain, and ATP synthase assembly factors. The abundance of MitoCoP proteins covers six orders of magnitude and amounts to 7% of the cellular proteome with the chaperones HSP60-HSP10 being the most abundant mitochondrial proteins. MitoCoP dynamics spans three orders of magnitudes, with half-lives from hours to months, and suggests a rapid regulation of biosynthesis and assembly processes. 460 MitoCoP genes are linked to human diseases with a strong prevalence for the central nervous system and metabolism. MitoCoP will provide a high-confidence resource for placing dynamics, functions, and dysfunctions of mitochondria into the cellular context.
KW  - mitochondria
KW  - human cells
KW  - high-confidence proteome
KW  - smORFs
KW  - copy numbers
KW  - half-lives
KW  - disease
KW  - complexome
KW  - protein translocation
KW  - respiratory chain
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-371114
VL  - 33
ER  -