TY  - THES
A1  - Kaufmann, Katharina
T1  - Aktivitätsverlauf, Funktionsstatus und Lebensqualität nach minimal-invasivem anteriorem Zugang bei Hüfttotalendoprothesen
T1  - Activity, functionality outcome and health-related quality of life using a minimally invasive anterior approach for total hip arthroplasty
N2  - Die Studie untersucht Aktivitätsverlauf, Funktionsstatus und Lebensqualität nach minimal-invasivem anteriorem Zugang bei Hüfttotalendoprothesen (präoperativ bis sechs Wochen postoperativ) mit Hilfe der Fragebögen PHQ-D, XSMFA-D, SF-36, HHS, Täglicher Würzburger Aktivitätsfragebogen, Arzt- u. Patientenbogen Hüfte.
N2  - This clinical study investigates activity, functionality outcome and health-related quality of life using a minimally invasive anterior approach for total hip arthroplasty (preoperatively up to six weeks postoperatively) using questionnaires inter alia PHQ-D, XSMFA-D, SF-36, HHS, Daily activity questionnaire (DAQ).
KW  - Endoprothese
KW  - Hüftgelenk
KW  - Klinisches Experiment
KW  - Aktivität
KW  - Funktion
KW  - Lebensqualität
KW  - minimal-invasiv
KW  - anteriorer Zugang
KW  - activity
KW  - functionality outcome
KW  - health-related quality of life
KW  - minimally invasive anterior approach
KW  - total hip arthroplasty
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-81583
ER  - 
TY  - JOUR
A1  - Walsh, J. Bernard
A1  - Lems, Willem F.
A1  - Karras, Dimitrios
A1  - Langdahl, Bente L.
A1  - Ljunggren, Osten
A1  - Fahrleitner-Pammer, Astrid
A1  - Barrett, Annabel
A1  - Rajzbaum, Gerald
A1  - Jakob, Franz
A1  - Marin, Fernando
T1  - Effectiveness of Teriparatide in Women Over 75 Years of Age with Severe Osteoporosis: 36-Month Results from the European Forsteo Observational Study (EFOS)
JF  - Calcified Tissue International
N2  - This predefined analysis of the European Forsteo Observational Study (EFOS) aimed to describe clinical fracture incidence, back pain, and health-related quality of life (HRQoL) during 18 months of teriparatide treatment and 18 months post-teriparatide in the subgroup of 589 postmenopausal women with osteoporosis aged ≥75 years. Data on clinical fractures, back pain (visual analogue scale, VAS), and HRQoL (EQ-5D) were collected over 36 months. Fracture data were summarized in 6-month intervals and analyzed using logistic regression with repeated measures. A repeated-measures model analyzed changes from baseline in back pain VAS and EQ-VAS. During the 36-month observation period, 87 (14.8 %) women aged ≥75 years sustained a total of 111 new fractures: 37 (33.3 %) vertebral fractures and 74 (66.7 %) nonvertebral fractures. Adjusted odds of fracture was decreased by 80 % in the 30 to <36–month interval compared with the first 6-month interval (P < 0.009). Although the older subgroup had higher back pain scores and poorer HRQoL at baseline than the younger subgroup, both age groups showed significant reductions in back pain and improvements in HRQoL postbaseline. In conclusion, women aged ≥75 years with severe postmenopausal osteoporosis treated with teriparatide in normal clinical practice showed a reduced clinical fracture incidence by 30 months compared with baseline. An improvement in HRQoL and, possibly, an early and significant reduction in back pain were also observed, which lasted for at least 18 months after teriparatide discontinuation when patients were taking other osteoporosis medication. The results should be interpreted in the context of an uncontrolled observational study.
KW  - teriparatide
KW  - osteoporosis
KW  - health-related quality of life
KW  - fracture
KW  - back pain
KW  - age
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-124746
VL  - 90
IS  - 5
ER  -