TY  - JOUR
A1  - Schneider, Wolfgang
T1  - Möglichkeiten der frühen Vorhersage von Leseleistungen im Grundschulalter
T1  - On the early prediction of reading abilities
N2  - Im vorliegenden Beitrag werdenneuere nends in der Forschung zur frühen Prognose von Leseleistungen dargestellt. Der Überblick ergibt, daß sich insbesondere solche Forschungsarbeiten bewährt haben, die an kognitiven Informationsverarbeitungsmodellen orientiert sind. Über die Verknüpfung von korrelativen Längsschnitt- und experimentellen Trainingsstudien ließ sich belegen, daß die im Vorschul- bzw. Kindergartenalter beobachtete Informationsverarbeitungskompetenz eine kausale Beziehung zu der schulischen Leseleistung aufwies. Es wurde weiterhin gezeigt, daß phonologische Kompetenzen im Vorschulalter auch effizient trainiert werden können. Trotz dieser insgesamt beeindruckenden Befunde scheinen individuelle Prognosen des Schriftspracherwerbs nach wie vor jedoch problematisch.
N2  - This paper gives an overview of recent developments in research deallog with the early prediction of reading success in elementary schools. As a main result, the review shows that studies based on information processing approaches seem to be most promising: Research combining correlationallongitudinal analyses with experimental training studies has demonstrated causal relationships between prescbool pbonological skills and reading achievement in elementary school. Further, it could be shown that phonological competencies can be successfully taught even in preschoolers. Despite these impressive results, bowever, predictions of individual reading development still cause severe problems.
KW  - Prognose
KW  - Lesen
KW  - Grundschulkind
Y1  - 1989
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86509
ER  - 
TY  - JOUR
A1  - Schneider, Wolfgang
T1  - Introduction: The early prediction of reading and spelling
N2  - No abstract available.
KW  - Prognose
KW  - Schreiben
KW  - Lesen
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87418
ER  - 
TY  - JOUR
A1  - Shityakov, Sergey
A1  - Förster, Carola
A1  - Rethwilm, Axel
A1  - Dandekar, Thomas
T1  - Evaluation and Prediction of the HIV-1 Central Polypurine Tract Influence on Foamy Viral Vectors to Transduce Dividing and Growth-Arrested Cells
N2  - Retroviral vectors are potent tools for gene delivery and various biomedical applications. To accomplish a gene transfer task successfully, retroviral vectors must effectively transduce diverse cell cultures at different phases of a cell cycle. However, very promising retroviral vectors based on the foamy viral (FV) backbone lack the capacity to efficiently transduce quiescent cells. It is hypothesized that this phenomenon might be explained as the inability of foamy viruses to form a pre-integration complex (PIC) with nuclear import activity in growth-arrested cells, which is the characteristic for lentiviruses (HIV-1). In this process, the HIV-1 central polypurine tract (cPPT) serves as a primer for plus-strand synthesis to produce a “flap” element and is believed to be crucial for the subsequent double-stranded cDNA formation of all retroviral RNA genomes. In this study, the effects of the lentiviral cPPT element on the FV transduction potential in dividing and growth-arrested (G1/S phase) adenocarcinomic human alveolar basal epithelial (A549) cells are investigated by experimental and theoretical methods. The results indicated that the HIV-1 cPPT element in a foamy viral vector background will lead to a significant reduction of the FV transduction and viral titre in growth-arrested cells due to the absence of PICs with nuclear import activity.
KW  - Evaluation
KW  - Prognose
KW  - HIV
KW  - Spumaviren
KW  - Einfluss
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-112763
ER  -