TY  - JOUR
A1  - Detomas, Mario
A1  - Pivonello, Claudia
A1  - Pellegrini, Bianca
A1  - Landwehr, Laura-Sophie
A1  - Sbiera, Silviu
A1  - Pivonello, Rosario
A1  - Ronchi, Cristina L.
A1  - Colao, Annamaria
A1  - Altieri, Barbara
A1  - De Martino, Maria Cristina
T1  - MicroRNAs and long non-coding RNAs in adrenocortical carcinoma
JF  - Cells
N2  - Non-coding RNAs (ncRNAs) are a type of genetic material that do not encode proteins but regulate the gene expression at an epigenetic level, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The role played by ncRNAs in many physiological and pathological processes has gained attention during the last few decades, as they might be useful in the diagnosis, treatment and management of several human disorders, including endocrine and oncological diseases. Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine cancer, still characterized by high mortality and morbidity due to both endocrine and oncological complications. Despite the rarity of this disease, recently, the role of ncRNA has been quite extensively evaluated in ACC. In order to better explore the role of the ncRNA in human ACC, this review summarizes the current knowledge on ncRNA dysregulation in ACC and its potential role in the diagnosis, treatment, and management of this tumor.
KW  - miRNA
KW  - lncRNA
KW  - adrenocortical tumor
KW  - ACC
KW  - adrenocortical adenoma
KW  - prognostic markers
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-281795
SN  - 2073-4409
VL  - 11
IS  - 14
ER  -