TY  - JOUR
A1  - Bogdan, Sven
A1  - Schultz, Jörg
A1  - Grosshans, Jörg
T1  - Formin’ cellular structures: Physiological roles of Diaphanous (Dia) in actin dynamics
JF  - Communicative & Integrative Biology
N2  - Members of the Diaphanous (Dia) protein family are key regulators of fundamental actin driven cellular processes, which are conserved from yeast to humans. Researchers have uncovered diverse physiological roles in cell morphology, cell motility, cell polarity, and cell division, which are involved in shaping cells into tissues and organs. The identification of numerous binding partners led to substantial progress in our understanding of the differential functions of Dia proteins. Genetic approaches and new microscopy techniques allow important new insights into their localization, activity, and molecular principles of regulation.
KW  - Drosophila
KW  - cytoskeleton
KW  - actin
KW  - nucleator
KW  - development
KW  - formin
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-121305
VL  - 6
IS  - e27634
ER  - 
TY  - JOUR
A1  - Beer, Katharina
A1  - Helfrich-Förster, Charlotte
T1  - Post-embryonic Development of the Circadian Clock Seems to Correlate With Social Life Style in Bees
JF  - Frontiers in Cell and Developmental Biology
N2  - Social life style can influence many aspects of an animal’s daily life, but it has not yet been clarified, whether development of the circadian clock in social and solitary living bees differs. In a comparative study, with the social honey bee, Apis mellifera, and the solitary mason bee, Osmia bicornis, we now found indications for a differentially timed clock development in social and solitary bees. Newly emerged solitary bees showed rhythmic locomotion right away and the number of neurons in the brain that produce the clock component pigment-dispersing factor (PDF) did not change during aging of the adult solitary bee. Honey bees on the other hand, showed no circadian locomotion directly after emergence and the neuronal clock network continued to grow after emergence. Social bees appear to emerge at an early developmental stage at which the circadian clock is still immature, but bees are already able to fulfill in-hive tasks.
KW  - social
KW  - honey bee
KW  - solitary bee
KW  - circadian clock
KW  - activity rhythm
KW  - neuronal network
KW  - development
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-216450
SN  - 2296-634X
VL  - 8
ER  - 
TY  - JOUR
A1  - Schuster, Sarah
A1  - Lisack, Jaime
A1  - Subota, Ines
A1  - Zimmermann, Henriette
A1  - Reuter, Christian
A1  - Mueller, Tobias
A1  - Morriswood, Brooke
A1  - Engstler, Markus
T1  - Unexpected plasiticty in the life cycle of Trypanosoma brucei
JF  - eLife
N2  - African trypanosomes cause sleeping sickness in humans and nagana in cattle. These unicellular parasites are transmitted by the bloodsucking tsetse fly. In the mammalian host’s circulation, proliferating slender stage cells differentiate into cell cycle-arrested stumpy stage cells when they reach high population densities. This stage transition is thought to fulfil two main functions: first, it auto-regulates the parasite load in the host; second, the stumpy stage is regarded as the only stage capable of successful vector transmission. Here, we show that proliferating slender stage trypanosomes express the mRNA and protein of a known stumpy stage marker, complete the complex life cycle in the fly as successfully as the stumpy stage, and require only a single parasite for productive infection. These findings suggest a reassessment of the traditional view of the trypanosome life cycle. They may also provide a solution to a long-lasting paradox, namely the successful transmission of parasites in chronic infections, despite low parasitemia.
KW  - trypanosoma
KW  - sleeping sickness
KW  - tsetse fly
KW  - transmission
KW  - life cycle
KW  - development
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-261744
VL  - 10
ER  -