TY  - JOUR
A1  - Widder, Anna
A1  - Kelm, Matthias
A1  - Reibetanz, Joachim
A1  - Wiegering, Armin
A1  - Matthes, Niels
A1  - Germer, Christoph-Thomas
A1  - Seyfried, Florian
A1  - Flemming, Sven
T1  - Robotic-assisted versus laparoscopic left hemicolectomy — postoperative inflammation status, short-term outcome and cost effectiveness
JF  - International Journal of Environmental Research and Public Health
N2  - Robotic-assisted colon surgery may contain advantages over the laparoscopic approach, but clear evidence is sparse. This study aimed to analyze postoperative inflammation status, short-term outcome and cost-effectiveness of robotic-assisted versus laparoscopic left hemicolectomy. All consecutive patients who received minimal-invasive left hemicolectomy at the Department of Surgery I at the University Hospital of Wuerzburg in 2021 were prospectively included. Importantly, no patient selection for either procedure was carried out. The robotic-assisted versus laparoscopic approaches were compared head to head for postoperative short-term outcomes as well as cost-effectiveness. A total of 61 patients were included, with 26 patients having received a robotic-assisted approach. Baseline characteristics did not differ among the groups. Patients receiving a robotic-assisted approach had a significantly decreased length of hospital stay as well as lower rates of complications in comparison to patients who received laparoscopic surgery (n = 35). In addition, C-reactive protein as a marker of systemic stress response was significantly reduced postoperatively in patients who were operated on in a robotic-assisted manner. Consequently, robotic-assisted surgery could be performed in a cost-effective manner. Thus, robotic-assisted left hemicolectomy represents a safe and cost-effective procedure and might improve patient outcomes in comparison to laparoscopic surgery.
KW  - robotic surgery
KW  - colon resection
KW  - postoperative inflammation
KW  - cost-effectiveness
KW  - left hemicolectomy
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-286203
SN  - 1660-4601
VL  - 19
IS  - 17
ER  - 
TY  - JOUR
A1  - Meir, Michael
A1  - Kannapin, Felix
A1  - Diefenbacher, Markus
A1  - Ghoreishi, Yalda
A1  - Kollmann, Catherine
A1  - Flemming, Sven
A1  - Germer, Christoph-Thomas
A1  - Waschke, Jens
A1  - Leven, Patrick
A1  - Schneider, Reiner
A1  - Wehner, Sven
A1  - Burkard, Natalie
A1  - Schlegel, Nicolas
T1  - Intestinal epithelial barrier maturation by enteric glial cells is GDNF-dependent
JF  - International Journal of Molecular Sciences
N2  - Enteric glial cells (EGCs) of the enteric nervous system are critically involved in the maintenance of intestinal epithelial barrier function (IEB). The underlying mechanisms remain undefined. Glial cell line-derived neurotrophic factor (GDNF) contributes to IEB maturation and may therefore be the predominant mediator of this process by EGCs. Using GFAP\(^{cre}\) x Ai14\(^{floxed}\) mice to isolate EGCs by Fluorescence-activated cell sorting (FACS), we confirmed that they synthesize GDNF in vivo as well as in primary cultures demonstrating that EGCs are a rich source of GDNF in vivo and in vitro. Co-culture of EGCs with Caco2 cells resulted in IEB maturation which was abrogated when GDNF was either depleted from EGC supernatants, or knocked down in EGCs or when the GDNF receptor RET was blocked. Further, TNFα-induced loss of IEB function in Caco2 cells and in organoids was attenuated by EGC supernatants or by recombinant GDNF. These barrier-protective effects were blunted when using supernatants from GDNF-deficient EGCs or by RET receptor blockade. Together, our data show that EGCs produce GDNF to maintain IEB function in vitro through the RET receptor.
KW  - enteric glial cells
KW  - neurotrophic factors
KW  - intestinal epithelial barrier
KW  - GDNF5
KW  - RET6
KW  - inflammatory bowel disease
KW  - enteric nervous system
KW  - gut barrier
KW  - intercellular junctions
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-258913
SN  - 1422-0067
VL  - 22
IS  - 4
ER  - 
TY  - JOUR
A1  - Diers, Johannes
A1  - Acar, Laura
A1  - Wagner, Johanna C.
A1  - Baum, Philip
A1  - Hankir, Mohammed
A1  - Flemming, Sven
A1  - Kastner, Carolin
A1  - Germer, Christoph-Thomas
A1  - L’hoest, Helmut
A1  - Marschall, Ursula
A1  - Lock, Johan Friso
A1  - Wiegering, Armin
T1  - Cancer diagnosis is one quarter lower than the expected cancer incidence in the first year of COVID-19 pandemic in Germany: A retrospective register-based cohort study
JF  - Cancer Communications
N2  - No abstract available.
KW  - cancer diagnosis
KW  - COVID-19 pandemic
KW  - Germany
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-312862
VL  - 42
IS  - 7
ER  -