TY  - JOUR
A1  - Hesselbach, Hannah
A1  - Seeger, Johannes
A1  - Schilcher, Felix
A1  - Ankenbrand, Markus
A1  - Scheiner, Ricarda
T1  - Chronic exposure to the pesticide flupyradifurone can lead to premature onset of foraging in honeybees Apis mellifera
JF  - Journal of Applied Ecology
N2  - 1.Honeybees Apis mellifera and other pollinating insects suffer from pesticides in agricultural landscapes. Flupyradifurone is the active ingredient of a novel pesticide by the name of ‘Sivanto’, introduced by Bayer AG (Crop Science Division, Monheim am Rhein, Germany). It is recommended against sucking insects and marketed as ‘harmless’ to honeybees. Flupyradifurone binds to nicotinergic acetylcholine receptors like neonicotinoids, but it has a different mode of action. So far, little is known on how sublethal flupyradifurone doses affect honeybees.

2. We chronically applied a sublethal and field‐realistic concentration of flupyradifurone to test for long‐term effects on flight behaviour using radio‐frequency identification. We examined haematoxylin/eosin‐stained brains of flupyradifurone‐treated bees to investigate possible changes in brain morphology and brain damage.

3. A field‐realistic flupyradifurone dose of approximately 1.0 μg/bee/day significantly increased mortality. Pesticide‐treated bees initiated foraging earlier than control bees. No morphological damage in the brain was observed.

4. Synthesis and applications. The early onset of foraging induced by a chronical application of flupyradifurone could be disadvantageous for honeybee colonies, reducing the period of in‐hive tasks and life expectancy of individuals. Radio‐frequency identification technology is a valuable tool for studying pesticide effects on lifetime foraging behaviour of insects.
KW  - radiofrequency identification
KW  - flight behaviour
KW  - flupyradifurone
KW  - foraging
KW  - histology
KW  - honeybee
KW  - insecticide
KW  - mortality
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-212769
VL  - 57
IS  - 3
ER  - 
TY  - JOUR
A1  - Matthes, Niels
A1  - Diers, Johannes
A1  - Schlegel, Nicolas
A1  - Hankir, Mohammed
A1  - Haubitz, Imme
A1  - Germer, Christoph-Thomas
A1  - Wiegering, Armin
T1  - Validation of MTL30 as a quality indicator for colorectal surgery
JF  - PLoS One
N2  - Background 
Valid indicators are required to measure surgical quality. These ideally should be sensitive and selective while being easy to understand and adjust. We propose here the MTL30 quality indicator which takes into account 30-day mortality, transfer within 30 days, and a length of stay of 30 days as composite markers of an uneventful operative/postoperative course. 

Methods 
Patients documented in the StuDoQ|Colon and StuDoQ|Rectal carcinoma register of the German Society for General and Visceral Surgery (DGAV) were analyzed with regard to the effects of patient and tumor-related risk factors as well as postoperative complications on the MTL30. 

Results 
In univariate analysis, the MTL30 correlated significantly with patient and tumor-related risk factors such as ASA score (p<0.001), age (p<0.001), or UICC stage (p<0.001). There was a high sensitivity for the postoperative occurrence of complications such as re-operations (p<0.001) or subsequent bleeding (p<0.001), as well as a significant correlation with the CDC classification (p<0.001). In multivariate analysis, patient-related risk factors and postoperative complications significantly increased the odds ratio for a positive MTL30. A negative MTL30 showed a high specify for an uneventful operative and postoperative course. 

Conclusion 
The MTL30 is a valid indicator of colorectal surgical quality.
KW  - surgical care
KW  - discharge definition
KW  - definition
KW  - mortality
KW  - pancreatectomy
KW  - complications
KW  - superior
KW  - capture
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-230530
VL  - 15
IS  - 8
ER  -