TY  - JOUR
A1  - Rieger, C. T.
A1  - Liss, B.
A1  - Mellinghoff, S.
A1  - Buchheidt, D.
A1  - Cornely, O. A.
A1  - Egerer, G.
A1  - Heinz, W. J.
A1  - Hentrich, M.
A1  - Maschmeyer, G.
A1  - Mayer, K.
A1  - Sandherr, M.
A1  - Silling, G.
A1  - Ullmann, A.
A1  - Vehreschild, M. J. G. T.
A1  - von Lilienfeld-Toal, M.
A1  - Wolf, H. H.
A1  - Lehners, N.
T1  - Anti-infective vaccination strategies in patients with hematologic malignancies or solid tumors-Guideline of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO)
JF  - Annals of Oncology
N2  - Infectious complications are a significant cause of morbidity and mortality in patients with malignancies specifically when receiving anticancer treatments. Prevention of infection through vaccines is an important aspect of clinical care of cancer patients. Immunocompromising effects of the underlying disease as well as of antineoplastic therapies need to be considered when devising vaccination strategies. This guideline provides clinical recommendations on vaccine use in cancer patients including autologous stem cell transplant recipients, while allogeneic stem cell transplantation is subject of a separate guideline. The document was prepared by the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) by reviewing currently available data and applying evidence-based medicine criteria.
KW  - infection
KW  - anti-infective vaccination
KW  - cancer
KW  - immunosuppression
KW  - autologous stem cell transplantation
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226196
VL  - 29
IS  - 6
ER  - 
TY  - JOUR
A1  - Froehlich, Matthias
A1  - Schwaneck, Eva C.
A1  - Gernert, Michael
A1  - Gadeholt, Ottar
A1  - Strunz, Patrick-Pascal
A1  - Morbach, Henner
A1  - Tony, Hans-Peter
A1  - Schmalzing, Marc
T1  - Autologous Stem Cell Transplantation in Common Variable Immunodeficiency: A Case of Successful Treatment of Severe Refractory Autoimmune Encephalitis
JF  - Frontiers in Immunology
N2  - Common variable immunodeficiency (CVID) is the most common primary immunodeficiency in adults. It is associated with hypogammaglobulinemia, recurring infections and autoimmune phenomena. Treatment includes immunoglobulin substitution and immunosuppressants. Autoimmune neurological manifestations of CVID are rare and occur predominantly as granulomatous disease. We report the case of a 35-year-old woman with CVID who developed autoimmune encephalitis as demonstrated by double cerebral biopsy. Infectious or malignant causes could be excluded. Despite intensive immunosuppressive therapy with common regimens no significant improvement could be achieved. Ultimately, an autologous hematopoietic stem cell transplantation (HSCT) was performed, resulting in lasting complete remission of the encephalitis. To our knowledge, this is the first report of refractory autoimmune phenomena in CVID treated by autologous HSCT.
KW  - common variable immunodeficiency
KW  - primary immunodeficiencies
KW  - autoimmunity
KW  - autologous stem cell transplantation
KW  - autoimmune encephalitis
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-206972
SN  - 1664-3224
VL  - 11
IS  - 1317
ER  -