TY  - JOUR
A1  - Van de Kerkhof, Noortje W. A.
A1  - Feenstra, Ilse
A1  - van der Heijden, Frank M. M. A.
A1  - de Leeuw, Nicole
A1  - Pfundt, Rolph
A1  - Stöber, Gerald
A1  - Egger, Jos I. M.
A1  - Verhoeven, Willem M. A.
T1  - Copy number variants in a sample of patients with psychotic disorders: is standard screening relevant for actual clinical practice?
JF  - Neuropsychiatric Disease and Treatment
N2  - With the introduction of new genetic techniques such as genome-wide array comparative genomic hybridization, studies on the putative genetic etiology of schizophrenia have focused on the detection of copy number variants (CNVs), ie, microdeletions and/or microduplications, that are estimated to be present in up to 3% of patients with schizophrenia. In this study, out of a sample of 100 patients with psychotic disorders, 80 were investigated by array for the presence of CNVs. The assessment of the severity of psychiatric symptoms was performed using standardized instruments and ICD-10 was applied for diagnostic classification. In three patients, a submicroscopic CNV was demonstrated, one with a loss in 1q21.1 and two with a gain in 1p13.3 and 7q11.2, respectively. The association between these or other CNVs and schizophrenia or schizophrenia-like psychoses and their clinical implications still remain equivocal. While the CNV affected genes may enhance the vulnerability for psychiatric disorders via effects on neuronal architecture, these insights have not resulted in major changes in clinical practice as yet. Therefore, genome-wide array analysis should presently be restricted to those patients in whom psychotic symptoms are paired with other signs, particularly dysmorphisms and intellectual impairment.
KW  - microarrays
KW  - spectrum disorders
KW  - schizophrenia
KW  - gene
KW  - psychopathology
KW  - polymorphisms
KW  - microdeletion
KW  - perspectives
KW  - association
KW  - environment
KW  - copy number variants
KW  - 1q21
KW  - 7q11.2
KW  - 1p13.3
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-134769
VL  - 8
ER  - 
TY  - JOUR
A1  - Scheiner, Christin
A1  - Seis, Christian
A1  - Kleindienst, Nikolaus
A1  - Buerger, Arne
T1  - Psychopathology, protective factors, and COVID-19 among adolescents: a structural equation model
JF  - International Journal of Environmental Research and Public Health
N2  - Since the outbreak of the COVID-19 pandemic in December 2019 and the associated restrictions, mental health in children and adolescents has been increasingly discussed in the media. Negative impacts of the pandemic, including a sharp increase in psychopathology and, consequently, reduced quality of life, appear to have particularly affected children and young people, who may be especially vulnerable to the adverse effects of isolation. Nevertheless, many children and adolescents have managed to cope well with the restrictions, without deterioration of their mental health. The present study therefore explored the links between COVID-19 infection (in oneself or a family member, as well as the death of a family member due to the virus), protective factors such as self-efficacy, resilience, self-esteem, and health-related quality of life, and measures of psychopathology such as depression scores, internalizing/externalizing problems, emotion dysregulation, and victimization. For this purpose, we examined data from 2129 adolescents (mean age = 12.31, SD = 0.67; 51% male; 6% born outside of Germany) using a structural equation model. We found medium to high loadings of the manifest variables with the latent variables (COVID-19, protective factors, and psychopathology). Protective factors showed a significant negative correlation with psychopathology. However, COVID-19 had a weak connection with psychopathology in our sample. External pandemic-related factors (e.g., restrictions) and their interaction with existing psychopathology or individual protective factors appear to have a greater influence on young people’s mental health than the impact of the virus per se. Sociopolitical efforts should be undertaken to foster prevention and promote individual resilience, especially in adolescence.
KW  - adolescence
KW  - mental health
KW  - psychopathology
KW  - protective factors
KW  - COVID-19
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-304475
SN  - 1660-4601
VL  - 20
IS  - 3
ER  -