TY  - JOUR
A1  - Fetsch, Corinna
A1  - Gaitzsch, Jens
A1  - Messager, Lea
A1  - Battaglia, Giuseppe
A1  - Luxenhofer, Roberts
T1  - Self-Assembly of Amphiphilic Block Copolypeptoids – Micelles, Worms and Polymersomes
JF  - Scientific Reports
N2  - Polypeptoids are an old but recently rediscovered polymer class with interesting synthetic, physico-chemical and biological characteristics. Here, we introduce new aromatic monomers, N-benzyl glycine N-carboxyanhydride and N-phenethyl glycine N-carboxyanhydride and their block copolymers with the hydrophilic polysarcosine. We compare their self-assembly in water and aqueous buffer with the self-assembly of amphiphilic block copolypeptoids with aliphatic side chains. The aggregates in water were investigated by dynamic light scattering and electron microscopy. We found a variety of morphologies, which were influenced by the polymer structure as well as by the preparation method. Overall, we found polymersomes, worm-like micelles and oligo-lamellar morphologies as well as some less defined aggregates of interconnected worms and vesicles. Such, this contribution may serve as a starting point for a more detailed investigation of the self-assembly behavior of the rich class of polypeptoids and for a better understanding between the differences in the aggregation behavior of non-uniform polypeptoids and uniform peptoids.
KW  - bioinspired materials
KW  - polymer characterization
KW  - polymer synthesis
KW  - polymers
KW  - self-assembly
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-147855
VL  - 6
ER  -