TY - JOUR A1 - Estrada, Veronica A1 - Krebbers, Julia A1 - Voss, Christian A1 - Brazda, Nicole A1 - Blazyca, Heinrich A1 - Illgen, Jennifer A1 - Seide, Klaus A1 - Jürgens, Christian A1 - Müller, Jörg A1 - Martini, Rudolf A1 - Trieu, Hoc Khiem A1 - Müller, Hans Werner T1 - Low-pressure micro-mechanical re-adaptation device sustainably and effectively improves locomotor recovery from complete spinal cord injury JF - Communications Biology N2 - Traumatic spinal cord injuries result in impairment or even complete loss of motor, sensory and autonomic functions. Recovery after complete spinal cord injury is very limited even in animal models receiving elaborate combinatorial treatments. Recently, we described an implantable microsystem (microconnector) for low-pressure re-adaption of severed spinal stumps in rat. Here we investigate the long-term structural and functional outcome following microconnector implantation after complete spinal cord transection. Re-adaptation of spinal stumps supports formation of a tissue bridge, glial and vascular cell invasion, motor axon regeneration and myelination, resulting in partial recovery of motor-evoked potentials and a thus far unmet improvement of locomotor behaviour. The recovery lasts for at least 5 months. Despite a late partial decline, motor recovery remains significantly superior to controls. Our findings demonstrate that microsystem technology can foster long-lasting functional improvement after complete spinal injury, providing a new and effective tool for combinatorial therapies. KW - implants KW - preclinical research KW - spinal cord injury Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227357 VL - 1 ER - TY - JOUR A1 - Dunce, James M. A1 - Milburn, Amy E. A1 - Gurusaran, Manickam A1 - da Cruz, Irene A1 - Sen, Lee T. A1 - Benavente, Ricardo A1 - Davies, Owen R. T1 - Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1 JF - Nature Communications N2 - Meiotic chromosomes undergo rapid prophase movements, which are thought to facilitate the formation of inter-homologue recombination intermediates that underlie synapsis, crossing over and segregation. The meiotic telomere complex (MAJIN, TERB1, TERB2) tethers telomere ends to the nuclear envelope and transmits cytoskeletal forces via the LINC complex to drive these rapid movements. Here, we report the molecular architecture of the meiotic telomere complex through the crystal structure of MAJIN-TERB2, together with light and X-ray scattering studies of wider complexes. The MAJIN-TERB2 2:2 hetero-tetramer binds strongly to DNA and is tethered through long flexible linkers to the inner nuclear membrane and two TRF1-binding 1:1 TERB2-TERB1 complexes. Our complementary structured illumination microscopy studies and biochemical findings reveal a telomere attachment mechanism in which MAJIN-TERB2-TERB1 recruits telomere-bound TRF1, which is then displaced during pachytene, allowing MAJIN-TERB2-TERB1 to bind telomeric DNA and form a mature attachment plate. KW - DNA KW - meiosis KW - proteins KW - super-resolution microscopy KW - X-ray crystallography Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226416 VL - 9 ER - TY - JOUR A1 - Dubail, Johanne A1 - Huber, Céline A1 - Chantepie, Sandrine A1 - Sonntag, Stephan A1 - Tüysüz, Beyhan A1 - Mihci, Ercan A1 - Gordon, Christopher T. A1 - Steichen-Gersdorf, Elisabeth A1 - Amiel, Jeanne A1 - Nur, Banu A1 - Stolte-Dijkstra, Irene A1 - van Eerde, Albertien M. A1 - van Gassen, Koen L. A1 - Breugem, Corstiaan C. A1 - Stegmann, Alexander A1 - Lekszas, Caroline A1 - Maroofian, Reza A1 - Karimiani, Ehsan Ghayoor A1 - Bruneel, Arnaud A1 - Seta, Nathalie A1 - Munnich, Arnold A1 - Papy-Garcia, Dulce A1 - De La Dure-Molla, Muriel A1 - Cormier-Daire, Valérie T1 - SLC10A7 mutations cause a skeletal dysplasia with amelogenesis imperfecta mediated by GAG biosynthesis defects JF - Nature Communications N2 - Skeletal dysplasia with multiple dislocations are severe disorders characterized by dislocations of large joints and short stature. The majority of them have been linked to pathogenic variants in genes encoding glycosyltransferases, sulfotransferases or epimerases required for glycosaminoglycan synthesis. Using exome sequencing, we identify homozygous mutations in SLC10A7 in six individuals with skeletal dysplasia with multiple dislocations and amelogenesis imperfecta. SLC10A7 encodes a 10-transmembrane-domain transporter located at the plasma membrane. Functional studies in vitro demonstrate that SLC10A7 mutations reduce SLC10A7 protein expression. We generate a Slc10a7−/− mouse model, which displays shortened long bones, growth plate disorganization and tooth enamel anomalies, recapitulating the human phenotype. Furthermore, we identify decreased heparan sulfate levels in Slc10a7−/− mouse cartilage and patient fibroblasts. Finally, we find an abnormal N-glycoprotein electrophoretic profile in patient blood samples. Together, our findings support the involvement of SLC10A7 in glycosaminoglycan synthesis and specifically in skeletal development. KW - bone development KW - disease genetics KW - medical genetics Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226377 VL - 9 ER - TY - JOUR A1 - Dostál, Jakub A1 - Fennel, Franziska A1 - Koch, Federico A1 - Herbst, Stefanie A1 - Würthner, Frank A1 - Brixner, Tobias T1 - Direct observation of exciton–exciton interactions JF - Nature Communications N2 - Natural light harvesting as well as optoelectronic and photovoltaic devices depend on efficient transport of energy following photoexcitation. Using common spectroscopic methods, however, it is challenging to discriminate one-exciton dynamics from multi-exciton interactions that arise when more than one excitation is present in the system. Here we introduce a coherent two-dimensional spectroscopic method that provides a signal only in case that the presence of one exciton influences the behavior of another one. Exemplarily, we monitor exciton diffusion by annihilation in a perylene bisimide-based J-aggregate. We determine quantitatively the exciton diffusion constant from exciton–exciton-interaction 2D spectra and reconstruct the annihilation-free dynamics for large pump powers. The latter enables for ultrafast spectroscopy at much higher intensities than conventionally possible and thus improves signal-to-noise ratios for multichromophore systems; the former recovers spatio–temporal dynamics for a broad range of phenomena in which exciton interactions are present. KW - energy transfer KW - self-assembly KW - optical spectroscopy Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226271 VL - 9 ER - TY - JOUR A1 - Dindas, Julian A1 - Scherzer, Sönke A1 - Roelfsema, M. Rob G. A1 - Meyer, Katharina von A1 - Müller, Heike M. A1 - Al-Rasheid, K. A. S. A1 - Palme, Klaus A1 - Dietrich, Petra A1 - Becker, Dirk A1 - Bennett, Malcolm J. A1 - Hedrich, Rainer T1 - AUX1-mediated root hair auxin influx governs SCFTIR1/AFB-type Ca2+ signaling JF - Nature Communications N2 - Auxin is a key regulator of plant growth and development, but the causal relationship between hormone transport and root responses remains unresolved. Here we describe auxin uptake, together with early steps in signaling, in Arabidopsis root hairs. Using intracellular microelectrodes we show membrane depolarization, in response to IAA in a concentration- and pH-dependent manner. This depolarization is strongly impaired in aux1 mutants, indicating that AUX1 is the major transporter for auxin uptake in root hairs. Local intracellular auxin application triggers Ca2+ signals that propagate as long-distance waves between root cells and modulate their auxin responses. AUX1-mediated IAA transport, as well as IAA- triggered calcium signals, are blocked by treatment with the SCFTIR1/AFB - inhibitor auxinole. Further, they are strongly reduced in the tir1afb2afb3 and the cngc14 mutant. Our study reveals that the AUX1 transporter, the SCFTIR1/AFB receptor and the CNGC14 Ca2+ channel, mediate fast auxin signaling in roots. KW - auxin KW - permeation and transport Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225368 VL - 9 ER - TY - JOUR A1 - de Jong, Simone A1 - Diniz, Mateus Jose Abdalla A1 - Saloma, Andiara A1 - Gadelha, Ary A1 - Santoro, Marcos L. A1 - Ota, Vanessa K. A1 - Noto, Cristiano A1 - Curtis, Charles A1 - Newhouse, Stephen J. A1 - Patel, Hamel A1 - Hall, Lynsey S. A1 - O'Reilly, Paul F. A1 - Belangero, Sintia I. A1 - Bressan, Rodrigo A. A1 - Breen, Gerome T1 - Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder JF - Communications Biology N2 - Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders. KW - bipolar disorder KW - depression KW - genetic association study KW - genetic linkage study Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-223622 VL - 1 ER - TY - JOUR A1 - Ciuchi, Sergio A1 - Di Sante, Domenico A1 - Dobrosavljević, Vladimir A1 - Fratini, Simone T1 - The origin of Mooij correlations in disordered metals JF - npj Quantum Materials N2 - Sufficiently disordered metals display systematic deviations from the behavior predicted by semi-classical Boltzmann transport theory. Here the scattering events from impurities or thermal excitations can no longer be considered as additive-independent processes, as asserted by Matthiessen’s rule following from this picture. In the intermediate region between the regime of good conduction and that of insulation, one typically finds a change of sign of the temperature coefficient of resistivity, even at elevated temperature spanning ambient conditions, a phenomenology that was first identified by Mooij in 1973. Traditional weak coupling approaches to identify relevant corrections to the Boltzmann picture focused on long-distance interference effects such as “weak localization”, which are especially important in low dimensions (1D and 2D) and close to the zero-temperature limit. Here we formulate a strong-coupling approach to tackle the interplay of strong disorder and lattice deformations (phonons) in bulk three-dimensional metals at high temperatures. We identify a polaronic mechanism of strong disorder renormalization, which describes how a lattice locally responds to the relevant impurity potential. This mechanism, which quantitatively captures the Mooij regime, is physically distinct and unrelated to Anderson localization, but realizes early seminal ideas of Anderson himself, concerning the interplay of disorder and lattice deformations. KW - electronic properties and materials KW - phase transitions and critical phenomena KW - theory and computation Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-223148 VL - 3 ER - TY - JOUR A1 - China, Swarup A1 - Burrows, Susannah M. A1 - Wang, Bingbing A1 - Harder, Tristan H. A1 - Weis, Johannes A1 - Tanarhte, Meryem A1 - Rizzo, Luciana V. A1 - Brito, Joel A1 - Cirino, Glauber G. A1 - Ma, Po-Lun A1 - Cliff, John A1 - Artaxo, Paulo A1 - Gilles, Mary K. A1 - Laskin, Alexander T1 - Fungal spores as a source of sodium salt particles in the Amazon basin JF - Nature Communications N2 - In the Amazon basin, particles containing mixed sodium salts are routinely observed and are attributed to marine aerosols transported from the Atlantic Ocean. Using chemical imaging analysis, we show that, during the wet season, fungal spores emitted by the forest biosphere contribute at least 30% (by number) to sodium salt particles in the central Amazon basin. Hydration experiments indicate that sodium content in fungal spores governs their growth factors. Modeling results suggest that fungal spores account for ~69% (31–95%) of the total sodium mass during the wet season and that their fractional contribution increases during nighttime. Contrary to common assumptions that sodium-containing aerosols originate primarily from marine sources, our results suggest that locally-emitted fungal spores contribute substantially to the number and mass of coarse particles containing sodium. Hence, their role in cloud formation and contribution to salt cycles and the terrestrial ecosystem in the Amazon basin warrant further consideration. KW - atmospheric chemistry KW - biogeochemistry KW - environmental sciences Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-222492 VL - 9 ER - TY - JOUR A1 - Castilho, Miguel A1 - Hochleitner, Gernot A1 - Wilson, Wouter A1 - van Rietbergen, Bert A1 - Dalton, Paul D. A1 - Groll, Jürgen A1 - Malda, Jos A1 - Ito, Keita T1 - Mechanical behavior of a soft hydrogel reinforced with three-dimensional printed microfibre scaffolds JF - Scientific Reports N2 - Reinforcing hydrogels with micro-fibre scaffolds obtained by a Melt-Electrospinning Writing (MEW) process has demonstrated great promise for developing tissue engineered (TE) constructs with mechanical properties compatible to native tissues. However, the mechanical performance and reinforcement mechanism of the micro-fibre reinforced hydrogels is not yet fully understood. In this study, FE models, implementing material properties measured experimentally, were used to explore the reinforcement mechanism of fibre-hydrogel composites. First, a continuum FE model based on idealized scaffold geometry was used to capture reinforcement effects related to the suppression of lateral gel expansion by the scaffold, while a second micro-FE model based on micro-CT images of the real construct geometry during compaction captured the effects of load transfer through the scaffold interconnections. Results demonstrate that the reinforcement mechanism at higher scaffold volume fractions was dominated by the load carrying-ability of the fibre scaffold interconnections, which was much higher than expected based on testing scaffolds alone because the hydrogel provides resistance against buckling of the scaffold. We propose that the theoretical understanding presented in this work will assist the design of more effective composite constructs with potential applications in a wide range of TE conditions. KW - biomedical engineering KW - biomedical materials KW - gels and hydrogels Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-222280 VL - 8 ER - TY - JOUR A1 - Carradec, Quentin A1 - Pelletier, Eric A1 - Da Silva, Corinne A1 - Alberti, Adriana A1 - Seeleuthner, Yoann A1 - Blanc-Mathieu, Romain A1 - Lima-Mendez, Gipsi A1 - Rocha, Fabio A1 - Tirichine, Leila A1 - Labadie, Karine A1 - Kirilovsky, Amos A1 - Bertrand, Alexis A1 - Engelen, Stefan A1 - Madoui, Mohammed-Amin A1 - Méheust, Raphaël A1 - Poulain, Julie A1 - Romac, Sarah A1 - Richter, Daniel J. A1 - Yoshikawa, Genki A1 - Dimier, Céline A1 - Kandels-Lewis, Stefanie A1 - Picheral, Marc A1 - Searson, Sarah A1 - Jaillon, Olivier A1 - Aury, Jean-Marc A1 - Karsenti, Eric A1 - Sullivan, Matthew B. A1 - Sunagawa, Shinichi A1 - Bork, Peer A1 - Not, Fabrice A1 - Hingamp, Pascal A1 - Raes, Jeroen A1 - Guidi, Lionel A1 - Ogata, Hiroyuki A1 - de Vargas, Colomban A1 - Iudicone, Daniele A1 - Bowler, Chris A1 - Wincker, Patrick T1 - A global ocean atlas of eukaryotic gene JF - Nature Communications N2 - While our knowledge about the roles of microbes and viruses in the ocean has increased tremendously due to recent advances in genomics and metagenomics, research on marine microbial eukaryotes and zooplankton has benefited much less from these new technologies because of their larger genomes, their enormous diversity, and largely unexplored physiologies. Here, we use a metatranscriptomics approach to capture expressed genes in open ocean Tara Oceans stations across four organismal size fractions. The individual sequence reads cluster into 116 million unigenes representing the largest reference collection of eukaryotic transcripts from any single biome. The catalog is used to unveil functions expressed by eukaryotic marine plankton, and to assess their functional biogeography. Almost half of the sequences have no similarity with known proteins, and a great number belong to new gene families with a restricted distribution in the ocean. Overall, the resource provides the foundations for exploring the roles of marine eukaryotes in ocean ecology and biogeochemistry. KW - genomics KW - marine biology KW - microbial ecology KW - water microbiology Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-222250 VL - 9 ER - TY - JOUR A1 - Brunk, Michael A1 - Sputh, Sebastian A1 - Doose, Sören A1 - van de Linde, Sebastian A1 - Terpitz, Ulrich T1 - HyphaTracker: An ImageJ toolbox for time-resolved analysis of spore germination in filamentous fungi JF - Scientific Reports N2 - The dynamics of early fungal development and its interference with physiological signals and environmental factors is yet poorly understood. Especially computational analysis tools for the evaluation of the process of early spore germination and germ tube formation are still lacking. For the time-resolved analysis of conidia germination of the filamentous ascomycete Fusarium fujikuroi we developed a straightforward toolbox implemented in ImageJ. It allows for processing of microscopic acquisitions (movies) of conidial germination starting with drift correction and data reduction prior to germling analysis. From the image time series germling related region of interests (ROIs) are extracted, which are analysed for their area, circularity, and timing. ROIs originating from germlings crossing other hyphae or the image boundaries are omitted during analysis. Each conidium/hypha is identified and related to its origin, thus allowing subsequent categorization. The efficiency of HyphaTracker was proofed and the accuracy was tested on simulated germlings at different signal-to-noise ratios. Bright-field microscopic images of conidial germination of rhodopsin-deficient F. fujikuroi mutants and their respective control strains were analysed with HyphaTracker. Consistent with our observation in earlier studies the CarO deficient mutant germinated earlier and grew faster than other, CarO expressing strains. KW - bioinformatics KW - cell growth KW - fungal biology KW - microscopy Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-221691 VL - 8 ER - TY - JOUR A1 - Bruchhagen, Christin A1 - Jarick, Marcel A1 - Mewis, Carolin A1 - Hertlein, Tobias A1 - Niemann, Silke A1 - Ohlsen, Knut A1 - Peters, Georg A1 - Planz, Oliver A1 - Ludwig, Stephan A1 - Ehrhardt, Christina T1 - Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound JF - Scientific Reports N2 - Influenza virus (IV) infections cause severe respiratory illnesses that can be complicated by bacterial super-infections. Previously, we identified the cellular Raf-MEK-ERK cascade as a promising antiviral target. Inhibitors of MEK, such as CI-1040, showed potent antiviral activity. However, it remained unclear if this inhibitor and its active form, ATR-002, might sensitize host cells to either IV or secondary bacterial infections. To address these questions, we studied the anti-pathogen activity of ATR-002 in comparison to CI-1040, particularly, its impact on Staphylococcus aureus (S. aureus), which is a major cause of IV super-infections. We analysed IV and S. aureus titres in vitro during super-infection in the presence and absence of the drugs and characterized the direct impact of ATR-002 on bacterial growth and phenotypic changes. Importantly, neither CI-1040 nor ATR-002 treatment led to increased bacterial titres during super-infection, indicating that the drug does not sensitize cells for bacterial infection. In contrast, we rather observed reduced bacterial titres in presence of ATR-002. Surprisingly, ATR-002 also led to reduced bacterial growth in suspension cultures, reduced stress- and antibiotic tolerance without resistance induction. Our data identified for the first time that a particular MEK-inhibitor metabolite exhibits direct antibacterial activity, which is likely due to interference with the bacterial PknB kinase/Stp phosphatase signalling system. KW - antimicrobials KW - pathogens Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-221648 VL - 8 ER - TY - JOUR A1 - Anany, Mohamed A. A1 - Kreckel, Jennifer A1 - Füllsack, Simone A1 - Rosenthal, Alevtina A1 - Otto, Christoph A1 - Siegmund, Daniela A1 - Wajant, Harald T1 - Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis JF - Cell Death & Disease N2 - TNF-like weak inducer of apoptosis (TWEAK) and inhibition of protein synthesis with cycloheximide (CHX) sensitize for poly(I:C)-induced cell death. Notably, although CHX preferentially enhanced poly(I:C)-induced apoptosis, TWEAK enhanced primarily poly(I:C)-induced necroptosis. Both sensitizers of poly(I:C)-induced cell death, however, showed no major effect on proinflammatory poly(I:C) signaling. Analysis of a panel of HeLa-RIPK3 variants lacking TRADD, RIPK1, FADD, or caspase-8 expression revealed furthermore similarities and differences in the way how poly(I:C)/TWEAK, TNF, and TRAIL utilize these molecules for signaling. RIPK1 turned out to be essential for poly(I:C)/TWEAK-induced caspase-8-mediated apoptosis but was dispensable for this response in TNF and TRAIL signaling. TRADD-RIPK1-double deficiency differentially affected poly(I:C)-triggered gene induction but abrogated gene induction by TNF completely. FADD deficiency abrogated TRAIL- but not TNF- and poly(I:C)-induced necroptosis, whereas TRADD elicited protective activity against all three death inducers. A general protective activity against poly(I:C)-, TRAIL-, and TNF-induced cell death was also observed in FLIPL and FLIPS transfectrants. Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-221104 VL - 9 ER - TY - JOUR A1 - Albrecht, Jörg A1 - Classen, Alice A1 - Vollstädt, Maximilian G.R. A1 - Mayr, Antonia A1 - Mollel, Neduvoto P. A1 - Schellenberger Costa, David A1 - Dulle, Hamadi I. A1 - Fischer, Markus A1 - Hemp, Andreas A1 - Howell, Kim M. A1 - Kleyer, Michael A1 - Nauss, Thomas A1 - Peters, Marcell K. A1 - Tschapka, Marco A1 - Steffan-Dewenter, Ingolf A1 - Böhning-Gaese, Katrin A1 - Schleuning, Matthias T1 - Plant and animal functional diversity drive mutualistic network assembly across an elevational gradient JF - Nature Communications N2 - Species' functional traits set the blueprint for pair-wise interactions in ecological networks. Yet, it is unknown to what extent the functional diversity of plant and animal communities controls network assembly along environmental gradients in real-world ecosystems. Here we address this question with a unique dataset of mutualistic bird-fruit, bird-flower and insect-flower interaction networks and associated functional traits of 200 plant and 282 animal species sampled along broad climate and land-use gradients on Mt. Kilimanjaro. We show that plant functional diversity is mainly limited by precipitation, while animal functional diversity is primarily limited by temperature. Furthermore, shifts in plant and animal functional diversity along the elevational gradient control the niche breadth and partitioning of the respective other trophic level. These findings reveal that climatic constraints on the functional diversity of either plants or animals determine the relative importance of bottom-up and top-down control in plant-animal interaction networks. KW - Traits-Environment Relationships KW - Species Traits KW - Ecological Networks KW - 4TH-Corner Problem KW - Multiple Traits KW - Bottom-up KW - Biodiversity KW - Community ecology KW - Ecological networks KW - Ecology KW - Ecosystem ecology Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-221056 VL - 9 ER - TY - JOUR T1 - Long-term monitoring of the ANTARES optical module efficiencies using \(^{40}\)K decays in sea water JF - European Physical Journal C N2 - Cherenkov light induced by radioactive decay products is one of the major sources of background light for deep-sea neutrino telescopes such as ANTARES. These decays are at the same time a powerful calibration source. Using data collected by the ANTARES neutrino telescope from mid 2008 to 2017, the time evolution of the photon detection efficiency of optical modules is studied. A modest loss of only 20% in 9 years is observed. The relative time calibration between adjacent modules is derived as well. KW - Neutrino Telescope KW - Dark-Matter KW - Calibration KW - System KW - Light Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227815 VL - 78 ER - TY - JOUR T1 - Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials JF - Lancet Oncology N2 - Background Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials. Methods We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively. Primary outcomes were tumour response, extent of local therapy, local and distant recurrence, breast cancer death, and overall mortality. Analyses by intention-to-treat used standard regression (for response and frequency of breast-conserving therapy) and log-rank methods (for recurrence and mortality). Findings Patients entered the trials from 1983 to 2002 and median follow-up was 9 years (IQR 5-14), with the last follow-up in 2013. Most chemotherapy was anthracycline based (3838 [81%] of 4756 women). More than two thirds (1349 [69%] of 1947) of women allocated NACT had a complete or partial clinical response. Patients allocated NACT had an increased frequency of breast-conserving therapy (1504 [65%] of 2320 treated with NACT vs 1135 [49%] of 2318 treated with adjuvant chemotherapy). NACT was associated with more frequent local recurrence than was adjuvant chemotherapy: the 15 year local recurrence was 21.4% for NACT versus 15.9% for adjuvant chemotherapy (5.5% increase [95% CI 2.4-8.6]; rate ratio 1.37 [95% CI 1.17-1.61]; p = 0.0001). No significant difference between NACT and adjuvant chemotherapy was noted for distant recurrence (15 year risk 38.2% for NACT vs 38.0% for adjuvant chemotherapy; rate ratio 1.02 [95% CI 0.92-1.14]; p = 0.66), breast cancer mortality (34.4% vs 33.7%; 1.06 [0.95-1.18]; p = 0.31), or death from any cause (40.9% vs 41.2%; 1.04 [0.94-1.15]; p = 0.45). Interpretation Tumours downsized by NACT might have higher local recurrence after breast-conserving therapy than might tumours of the same dimensions in women who have not received NACT. Strategies to mitigate the increased local recurrence after breast-conserving therapy in tumours downsized by NACT should be considered-eg, careful tumour localisation, detailed pathological assessment, and appropriate radiotherapy. Copyright (c) The Author(s). Published by Elsevier Ltd. KW - Stimulating factor KW - Therapy KW - Methotrexate KW - Radiotherapy KW - Survival KW - Surgery Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227782 VL - 19 IS - 1 ER - TY - JOUR T1 - Characterisation of the Hamamatsu photomultipliers for the KM3NeT Neutrino Telescope JF - Journal of Instrumentation N2 - The Hamamatsu R12199-023-inch photomultiplier tube is the photodetector chosen for the first phase of the KM3NeT neutrino telescope. About 7000 photomultipliers have been characterised for dark count rate, timing spread and spurious pulses. The quantum efficiency, the gain and the peak-to-valley ratio have also been measured for a sub-sample in order to determine parameter values needed as input to numerical simulations of the detector. KW - Cherenkov detectors KW - Large detector systems for particle and astroparticle physics KW - Neutrino detectors KW - Photon detectors for UV, visible and IR photons (vacuum) KW - Prototype Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227744 VL - 13 ER - TY - JOUR A1 - Abt, Raimond A1 - Erdmenger, Johanna T1 - Properties of modular Hamiltonians on entanglement plateaux JF - Journal of High Energy Physics N2 - The modular Hamiltonian of reduced states, given essentially by the logarithm of the reduced density matrix, plays an important role within the AdS/CFT correspondence in view of its relation to quantum information. In particular, it is an essential ingredient for quantum information measures of distances between states, such as the relative entropy and the Fisher information metric. However, the modular Hamiltonian is known explicitly only for a few examples. For a family of states rho(lambda) that is parametrized by a scalar lambda, the first order contribution in (lambda) over tilde = lambda-lambda(0) of the modular Hamiltonian to the relative entropy between rho(lambda) and a reference state rho(lambda 0) is completely determined by the entanglement entropy, via the first law of entanglement. For several examples, e.g. for ball-shaped regions in the ground state of CFTs, higher order contributions are known to vanish. In these cases the modular Hamiltonian contributes to the Fisher information metric in a trivial way. We investigate under which conditions the modular Hamiltonian provides a non-trivial contribution to the Fisher information metric, i.e. when the contribution of the modular Hamiltonian to the relative entropy is of higher order in (lambda) over tilde. We consider one-parameter families of reduced states on two entangling regions that form an entanglement plateau, i.e. the entanglement entropies of the two regions saturate the Araki-Lieb inequality. We show that in general, at least one of the relative entropies of the two entangling regions is expected to involve (lambda) over tilde contributions of higher order from the modular Hamiltonian. Furthermore, we consider the implications of this observation for prominent AdS/CFT examples that form entanglement plateaux in the large N limit. KW - AdS-CFT Correspondence KW - Gauge-gravity correspondence KW - Conformal Field Theory KW - Relative Entropy KW - Complexity Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227693 VL - 11 IS - 2 ER - TY - JOUR A1 - Klenke, Daniela A1 - Quast, Anja A1 - Prelog, Martina A1 - Holl-Wieden, Annette A1 - Riekert, Maximilian A1 - Stellzig-Eisenhauer, Angelika A1 - Meyer-Marcotty, Philipp T1 - TMJ pathomorphology in patients with JIA-radiographic parameters for early diagnosis- JF - Head & Face Medicine N2 - Background Juvenile idiopathic arthritis (JIA) is often accompanied by pathomorphological changes to the temporomandibular joint (TMJ). By analyzing orthodontical orthopantomograms of JIA patients the aims of the study were a) classification of condyle changes, b) quantification of bony asymmetries of condylar destruction and c) detection of relationships between disease duration and TMJ-involvement. Patients/Methods 46 caucasian JIA-patients (28 female; 18 male; < 16.0 years) were enrolled, each joint (n = 92) was morphologically assessed by means of orthopantomogram, quantitatively analysed and compared with duration of general disease. Condyle morphology was assessed using the Billiau scale for severity of destruction [1]. The quantitative analysis was based on ratios of condyle, ramus and mandible height. Results Patients were divided into groups (Group I – slightly affected, n = 36; Billiau severity 0–2; condyle findings: X-ray normal, condyle erosions, condylar flattening; Group II – severely affected, N = 10; Billiau severity 3–4; condyle findings: condylar flattenings and erosions, unilateral/bilateral complete loss of condyles), based on morphological analysis of condylar destruction. Duration of disease was significantly longer in Group II (8.9 ± 5.2 years) than in Group I (4.6 ± 4.7 years). Asymmetries of condyle, ramus and mandible height, quantitatively analysed by contralateral comparison, were significantly more marked in patients of Group II than of Group I. Conclusions Orthopantomogram imaging can be used in orthodontics clinical routine to detect TMJ-pathologies and is an important reference for monitoring progression of JIA. Classification into severe and slightly affected TMJ is possible by analysis of condylar pathomorphology. An association between degree of destruction, extent of lower jaw asymmetry and disease duration is suggested by the results. KW - juvenile idiopathic arthritis KW - TMJ KW - OPT KW - asymmetry KW - condyle pathomorphology Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-325882 VL - 14 ER - TY - JOUR A1 - Semler, Elisa A1 - Anderl-Straub, Sarah A1 - Uttner, Ingo A1 - Diehl-Schmid, Janine A1 - Danek, Adrian A1 - Einsiedler, Beate A1 - Fassbender, Klaus A1 - Fliessbach, Klaus A1 - Huppertz, Hans-Jürgen A1 - Jahn, Holger A1 - Kornhuber, Johannes A1 - Landwehrmeyer, Bernhard A1 - Lauer, Martin A1 - Muche, Rainer A1 - Prudlo, Johannes A1 - Schneider, Anja A1 - Schroeter, Matthias L. A1 - Ludolph, Albert C. A1 - Otto, Markus T1 - A language-based sum score for the course and therapeutic intervention in primary progressive aphasia JF - Alzheimer's Research & Therapy N2 - Background With upcoming therapeutic interventions for patients with primary progressive aphasia (PPA), instruments for the follow-up of patients are needed to describe disease progression and to evaluate potential therapeutic effects. So far, volumetric brain changes have been proposed as clinical endpoints in the literature, but cognitive scores are still lacking. This study followed disease progression predominantly in language-based performance within 1 year and defined a PPA sum score which can be used in therapeutic interventions. Methods We assessed 28 patients with nonfluent variant PPA, 17 with semantic variant PPA, 13 with logopenic variant PPA, and 28 healthy controls in detail for 1 year. The most informative neuropsychological assessments were combined to a sum score, and associations between brain atrophy were investigated followed by a sample size calculation for clinical trials. Results Significant absolute changes up to 20% in cognitive tests were found after 1 year. Semantic and phonemic word fluency, Boston Naming Test, Digit Span, Token Test, AAT Written language, and Cookie Test were identified as the best markers for disease progression. These tasks provide the basis of a new PPA sum score. Assuming a therapeutic effect of 50% reduction in cognitive decline for sample size calculations, a number of 56 cases is needed to find a significant treatment effect. Correlations between cognitive decline and atrophy showed a correlation up to r = 0.7 between the sum score and frontal structures, namely the superior and inferior frontal gyrus, as well as with left-sided subcortical structures. Conclusion Our findings support the high performance of the proposed sum score in the follow-up of PPA and recommend it as an outcome measure in intervention studies. KW - frontotemporal dementia KW - cognitive neuropsychology in dementia KW - assessment of cognitive disorders/dementia KW - volumetric MRI KW - aphasia Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-236277 VL - 10 ER - TY - JOUR A1 - Andratschke, N. A1 - Alheid, H. A1 - Allgäuer, M. A1 - Becker, G. A1 - Blanck, O. A1 - Boda-Heggemann, J. A1 - Brunner, T. A1 - Duma, M. A1 - Gerum, S. A1 - Guckenberger, M. A1 - Hildebrandt, G. A1 - Klement, R. J. A1 - Lewitzki, V. A1 - Ostheimer, C. A1 - Papachristofilou, A. A1 - Petersen, C. A1 - Schneider, T. A1 - Semrau, R. A1 - Wachter, S. A1 - Habermehl, D. T1 - The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases JF - BMC Cancer N2 - Background The intent of this pooled analysis as part of the German society for radiation oncology (DEGRO) stereotactic body radiotherapy (SBRT) initiative was to analyze the patterns of care of SBRT for liver oligometastases and to derive factors influencing treated metastases control and overall survival in a large patient cohort. Methods From 17 German and Swiss centers, data on all patients treated for liver oligometastases with SBRT since its introduction in 1997 has been collected and entered into a centralized database. In addition to patient and tumor characteristics, data on immobilization, image guidance and motion management as well as dose prescription and fractionation has been gathered. Besides dose response and survival statistics, time trends of the aforementioned variables have been investigated. Results In total, 474 patients with 623 liver oligometastases (median 1 lesion/patient; range 1–4) have been collected from 1997 until 2015. Predominant histologies were colorectal cancer (n = 213 pts.; 300 lesions) and breast cancer (n = 57; 81 lesions). All centers employed an SBRT specific setup. Initially, stereotactic coordinates and CT simulation were used for treatment set-up (55%), but eventually were replaced by CBCT guidance (28%) or more recently robotic tracking (17%). High variance in fraction (fx) number (median 1 fx; range 1–13) and dose per fraction (median: 18.5 Gy; range 3–37.5 Gy) was observed, although median BED remained consistently high after an initial learning curve. Median follow-up time was 15 months; median overall survival after SBRT was 24 months. One- and 2-year treated metastases control rate of treated lesions was 77% and 64%; if maximum isocenter biological equivalent dose (BED) was greater than 150 Gy EQD2Gy, it increased to 83% and 70%, respectively. Besides radiation dose colorectal and breast histology and motion management methods were associated with improved treated metastases control. Conclusion After an initial learning curve with regards to total cumulative doses, consistently high biologically effective doses have been employed translating into high local tumor control at 1 and 2 years. The true impact of histology and motion management method on treated metastases control deserve deeper analysis. Overall survival is mainly influenced by histology and metastatic tumor burden. KW - stereotactic body radiotherapy KW - liver oligometastases KW - outcome KW - treated metastases control KW - oligometastases KW - oligo-recurrence KW - sync-oligometastases Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-221116 VL - 18 ER - TY - JOUR A1 - Breuer, René A1 - Mattheisen, Manuel A1 - Frank, Josef A1 - Krumm, Bertram A1 - Treutlein, Jens A1 - Kassem, Layla A1 - Strohmaier, Jana A1 - Herms, Stefan A1 - Mühleisen, Thomas W. A1 - Degenhardt, Franziska A1 - Cichon, Sven A1 - Nöthen, Markus M. A1 - Karypis, George A1 - Kelsoe, John A1 - Greenwood, Tiffany A1 - Nievergelt, Caroline A1 - Shilling, Paul A1 - Shekhtman, Tatyana A1 - Edenberg, Howard A1 - Craig, David A1 - Szelinger, Szabolcs A1 - Nurnberger, John A1 - Gershon, Elliot A1 - Alliey-Rodriguez, Ney A1 - Zandi, Peter A1 - Goes, Fernando A1 - Schork, Nicholas A1 - Smith, Erin A1 - Koller, Daniel A1 - Zhang, Peng A1 - Badner, Judith A1 - Berrettini, Wade A1 - Bloss, Cinnamon A1 - Byerley, William A1 - Coryell, William A1 - Foroud, Tatiana A1 - Guo, Yirin A1 - Hipolito, Maria A1 - Keating, Brendan A1 - Lawson, William A1 - Liu, Chunyu A1 - Mahon, Pamela A1 - McInnis, Melvin A1 - Murray, Sarah A1 - Nwulia, Evaristus A1 - Potash, James A1 - Rice, John A1 - Scheftner, William A1 - Zöllner, Sebastian A1 - McMahon, Francis J. A1 - Rietschel, Marcella A1 - Schulze, Thomas G. T1 - Detecting significant genotype–phenotype association rules in bipolar disorder: market research meets complex genetics JF - International Journal of Bipolar Disorders N2 - Background Disentangling the etiology of common, complex diseases is a major challenge in genetic research. For bipolar disorder (BD), several genome-wide association studies (GWAS) have been performed. Similar to other complex disorders, major breakthroughs in explaining the high heritability of BD through GWAS have remained elusive. To overcome this dilemma, genetic research into BD, has embraced a variety of strategies such as the formation of large consortia to increase sample size and sequencing approaches. Here we advocate a complementary approach making use of already existing GWAS data: a novel data mining procedure to identify yet undetected genotype–phenotype relationships. We adapted association rule mining, a data mining technique traditionally used in retail market research, to identify frequent and characteristic genotype patterns showing strong associations to phenotype clusters. We applied this strategy to three independent GWAS datasets from 2835 phenotypically characterized patients with BD. In a discovery step, 20,882 candidate association rules were extracted. Results Two of these rules—one associated with eating disorder and the other with anxiety—remained significant in an independent dataset after robust correction for multiple testing. Both showed considerable effect sizes (odds ratio ~ 3.4 and 3.0, respectively) and support previously reported molecular biological findings. Conclusion Our approach detected novel specific genotype–phenotype relationships in BD that were missed by standard analyses like GWAS. While we developed and applied our method within the context of BD gene discovery, it may facilitate identifying highly specific genotype–phenotype relationships in subsets of genome-wide data sets of other complex phenotype with similar epidemiological properties and challenges to gene discovery efforts. KW - bipolar disorder KW - subphenotypes KW - rule discovery KW - data mining KW - genotype-phenotype patterns Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220509 VL - 6 ER - TY - JOUR A1 - Coelho, Luis Pedro A1 - Kultima, Jens Roat A1 - Costea, Paul Igor A1 - Fournier, Coralie A1 - Pan, Yuanlong A1 - Czarnecki-Maulden, Gail A1 - Hayward, Matthew Robert A1 - Forslund, Sofia K. A1 - Schmidt, Thomas Sebastian Benedikt A1 - Descombes, Patrick A1 - Jackson, Janet R. A1 - Li, Qinghong A1 - Bork, Peer T1 - Similarity of the dog and human gut microbiomes in gene content and response to diet JF - Microbiome N2 - Background Gut microbes influence their hosts in many ways, in particular by modulating the impact of diet. These effects have been studied most extensively in humans and mice. In this work, we used whole genome metagenomics to investigate the relationship between the gut metagenomes of dogs, humans, mice, and pigs. Results We present a dog gut microbiome gene catalog containing 1,247,405 genes (based on 129 metagenomes and a total of 1.9 terabasepairs of sequencing data). Based on this catalog and taxonomic abundance profiling, we show that the dog microbiome is closer to the human microbiome than the microbiome of either pigs or mice. To investigate this similarity in terms of response to dietary changes, we report on a randomized intervention with two diets (high-protein/low-carbohydrate vs. lower protein/higher carbohydrate). We show that diet has a large and reproducible effect on the dog microbiome, independent of breed or sex. Moreover, the responses were in agreement with those observed in previous human studies. Conclusions We conclude that findings in dogs may be predictive of human microbiome results. In particular, a novel finding is that overweight or obese dogs experience larger compositional shifts than lean dogs in response to a high-protein diet. KW - microbiome KW - diet KW - metagenomics KW - dog microbiome KW - human microbiome KW - mouse microbiome KW - pig microbiome Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-223177 VL - 6 ER - TY - JOUR A1 - Wevrett, Jill A1 - Fenwick, Andrew A1 - Scuffham, James A1 - Johansson, Lena A1 - Gear, Jonathan A1 - Schlögl, Susanne A1 - Segbers, Marcel A1 - Sjögreen-Gleisner, Katarina A1 - Solný, Pavel A1 - Lassmann, Michael A1 - Tipping, Jill A1 - Nisbet, Andrew T1 - Inter-comparison of quantitative imaging of lutetium-177 (\(^{177}\)Lu) in European hospitals JF - EJNMMI Physics N2 - Background This inter-comparison exercise was performed to demonstrate the variability of quantitative SPECT/CT imaging for lutetium-177 (\(^{177}\)Lu) in current clinical practice. Our aim was to assess the feasibility of using international inter-comparison exercises as a means to ensure consistency between clinical sites whilst enabling the sites to use their own choice of quantitative imaging protocols, specific to their systems. Dual-compartment concentric spherical sources of accurately known activity concentrations were prepared and sent to seven European clinical sites. The site staff were not aware of the true volumes or activity within the sources—they performed SPECT/CT imaging of the source, positioned within a water-filled phantom, using their own choice of parameters and reported their estimate of the activities within the source. Results The volumes reported by the participants for the inner section of the source were all within 29% of the true value and within 60% of the true value for the outer section. The activities reported by the participants for the inner section of the source were all within 20% of the true value, whilst those reported for the outer section were up to 83% different to the true value. Conclusions A variety of calibration and segmentation methods were used by the participants for this exercise which demonstrated the variability of quantitative imaging across clinical sites. This paper presents a method to assess consistency between sites using different calibration and segmentation methods. KW - Lutetium KW - Lu-177 KW - SPECT/CT KW - quantitative imaging KW - PRRT KW - molecular radiotherapy Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-233658 VL - 5 ER - TY - JOUR A1 - Zeiner, P. S. A1 - Zinke, J. A1 - Kowalewski, D. J. A1 - Bernatz, S. A1 - Tichy, J. A1 - Ronellenfitsch, M. W. A1 - Thorsen, F. A1 - Berger, A. A1 - Forster, M. T. A1 - Muller, A. A1 - Steinbach, J. P. A1 - Beschorner, R. A1 - Wischhusen, J. A1 - Kvasnicka, H. M. A1 - Plate, K. H. A1 - Stefanović, S. A1 - Weide, B. A1 - Mittelbronn, M. A1 - Harter, P. N. T1 - CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival JF - Acta Neuropathologica Communications N2 - Abstract Despite multidisciplinary local and systemic therapeutic approaches, the prognosis for most patients with brain metastases is still dismal. The role of adaptive and innate anti-tumor response including the Human Leukocyte Antigen (HLA) machinery of antigen presentation is still unclear. We present data on the HLA class II-chaperone molecule CD74 in brain metastases and its impact on the HLA peptidome complexity. We analyzed CD74 and HLA class II expression on tumor cells in a subset of 236 human brain metastases, primary tumors and peripheral metastases of different entities in association with clinical data including overall survival. Additionally, we assessed whole DNA methylome profiles including CD74 promoter methylation and differential methylation in 21 brain metastases. We analyzed the effects of a siRNA mediated CD74 knockdown on HLA-expression and HLA peptidome composition in a brain metastatic melanoma cell line. We observed that CD74 expression on tumor cells is a strong positive prognostic marker in brain metastasis patients and positively associated with tumor-infiltrating T-lymphocytes (TILs). Whole DNA methylome analysis suggested that CD74 tumor cell expression might be regulated epigenetically via CD74 promoter methylation. CD74\(^{high}\) and TIL\(^{high}\) tumors displayed a differential DNA methylation pattern with highest enrichment scores for antigen processing and presentation. Furthermore, CD74 knockdown in vitro lead to a reduction of HLA class II peptidome complexity, while HLA class I peptidome remained unaffected. In summary, our results demonstrate that a functional HLA class II processing machinery in brain metastatic tumor cells, reflected by a high expression of CD74 and a complex tumor cell HLA peptidome, seems to be crucial for better patient prognosis. KW - CD74 KW - HLA class II KW - brain metastasis KW - HLA peptidome KW - tumor infiltrating lymphocytes Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-233882 VL - 6 ER - TY - JOUR T1 - Measurement of differential cross sections of isolated-photon plus heavy-flavour jet production in \(pp\) collisions at √\(s\) = 8 TeV using the ATLAS detector JF - Physics Letters B N2 - This Letter presents the measurement of differential cross sections of isolated prompt photons produced in association with a b-jet or a c-jet. These final states provide sensitivity to the heavy-flavour content of the proton and aspects related to the modelling of heavy-flavour quarks in perturbative QCD. The measurement uses proton–proton collision data at a centre-of-mass energy of 8 TeV recorded by the ATLAS detector at the LHC in 2012 corresponding to an integrated luminosity of up to 20.2 fb−1 . The differential cross sections are measured for each jet flavour with respect to the transverse energy of the leading photon in two photon pseudorapidity regions: |η γ | < 1.37 and 1.56 < |η γ | < 2.37. The measurement covers photon transverse energies 25 < Eγ T < 400 GeV and 25 < Eγ T < 350 GeV respectively for the two |η γ | regions. For each jet flavour, the ratio of the cross sections in the two |η γ | regions is also measured. The measurement is corrected for detector effects and compared to leading-order and next- to-leading-order perturbative QCD calculations, based on various treatments and assumptions about the heavy-flavour content of the proton. Overall, the predictions agree well with the measurement, but some deviations are observed at high photon transverse energies. The total uncertainty in the measurement ranges between 13% and 66%, while the central γ + b measurement exhibits the smallest uncertainty, ranging from 13% to 27%, which is comparable to the precision of the theoretical predictions. KW - Intrinsic charm KW - Showers Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-347841 VL - 776 ER - TY - JOUR T1 - Direct top-quark decay width measurement in the t(t)over-bar lepton+jets channel at root \(s\)=8 TeV with the ATLAS experiment JF - European Physical Journal C N2 - This paper presents a direct measurement of the decay width of the top quark using t (t) over bar events in the lepton+jets final state. The data sample was collected by the ATLAS detector at the LHC in proton-proton collisions at a centre-of-mass energy of 8 TeV and corresponds to an integrated luminosity of 20.2 fb(-1). The decay width of the top quark is measured using a template fit to distributions of kinematic observables associated with the hadronically and semileptonically decaying top quarks. The result, Gamma(t) = 1.76 +/- 0.33 (stat.) (+0.79)(-0.68) (syst.) GeV for a top-quark mass of 172.5 GeV, is consistent with the prediction of the Standard Model. KW - Parton Distributions KW - Hadron Colliders KW - Pair Production KW - Cross-Section KW - pp Collisions Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226805 VL - 78 IS - 129 ER - TY - JOUR T1 - Measurement of τ polarisation in \(Z/\)γ* -> τ τ decays in proton-proton collisions at root \(s\)=8 TeV with the ATLAS detector JF - European Physical Journal C N2 - This paper presents a measurement of the polarisation of tau leptons produced in Z/gamma* -> tau tau decays which is performed with a dataset of proton-proton collisions at root s = 8 TeV, corresponding to an integrated luminosity of 20.2 fb(-1) recorded with the ATLAS detector at the LHC in 2012. The Z/gamma* -> tau tau decays are reconstructed from a hadronically decaying tau lepton with a single charged particle in the final state, accompanied by a tau lepton that decays leptonically. The tau polarisation is inferred from the relative fraction of energy carried by charged and neutral hadrons in the hadronic tau decays. The polarisation is measured in a fiducial region that corresponds to the kinematic region accessible to this analysis. The tau polarisation extracted over the full phase space within the Z/gamma* mass range of 66 < mZ/gamma* < 116GeVis found to be P-tau = -0.14 +/- 0.02(stat)+/- 0.04(syst). It is in agreement with the Standard Model prediction of Pt = -0.1517 +/- 0.0019, which is obtained from the ALP-GEN event generator interfaced with the PYTHIA 6 parton shower modelling and the TAUOLA tau decay library. KW - Monte-Carlo KW - pp Collisions KW - Simulation Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226794 VL - 78 IS - 163 ER - TY - JOUR T1 - Constraints on off-shell Higgs boson production and the Higgs boson total width in \(ZZ\) → 4l and \(ZZ\) → 2l2ν final states with the ATLAS detector JF - Physics Letters B N2 - A measurement of off-shell Higgs boson production in the ZZ -> 4l and ZZ -> 2l2v decay channels, where stands for either an electron or a muon, is performed using data from proton-proton collisions at a centre-of-mass energy of root s = 13 TeV. The data were collected by the ATLAS experiment in 2015 and 2016 at the Large Hadron Collider, and they correspond to an integrated luminosity of 36.1 fb(-1). An observed (expected) upper limit on the off-shell Higgs signal strength, defined as the event yield normalised to the Standard Model prediction, of 3.8 (3.4) is obtained at 95% confidence level (CL). Assuming the ratio of the Higgs boson couplings to the Standard Model predictions is independent of the momentum transfer of the Higgs production mechanism considered in the analysis, a combination with the on-shell signal-strength measurements yields an observed (expected) 95% CL upper limit on the Higgs boson total width of 14.4 (15.2) MeV. KW - Parton Distributions KW - Search KW - Decay KW - Mass Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-346791 VL - 786 ER - TY - JOUR T1 - Search for \({WW/WZ}\) resonance production in \(lvqq\) final states in \(pp\) collisions at root \(s\)=13 TeV with the ATLAS detector JF - Journal of High Energy Physics N2 - A search is conducted for new resonances decaying into a WW or WZ boson pair, where one W boson decays leptonically and the other W or Z boson decays hadronically. It is based on proton-proton collision data with an integrated luminosity of 36.1 fb(-1) collected with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of root s = 13 TeV in 2015 and 2016. The search is sensitive to diboson resonance production via vector-boson fusion as well as quark-antiquark annihilation and gluon-gluon fusion mechanisms. No significant excess of events is observed with respect to the Standard Model backgrounds. Several benchmark models are used to interpret the results. Limits on the production cross section are set for a new narrow scalar resonance, a new heavy vector-boson and a spin-2 Kaluza-Klein graviton. KW - Hadron-Hadron scattering (experiments) KW - ++ KW - HIGGS Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226787 VL - 42 ER - TY - JOUR T1 - Measurements of Higgs boson properties in the diphoton decay channel with 36 fb\(^{-1}\) of \(pp\) collision data at root \(s\)=13 TeV with the ATLAS detector JF - Physical Review D N2 - Properties of the Higgs boson are measured in the two-photon final state using 36.1 fb(-1) of proton-proton collision data recorded at root s = 13 TeV by the ATLAS experiment at the Large Hadron Collider. Cross-section measurements for the production of a Higgs boson through gluon-gluon fusion, vector-boson fusion, and in association with a vector boson or a top-quark pair are reported. The signal strength, defined as the ratio of the observed to the expected signal yield, is measured for each of these production processes as well as inclusively. The global signal strength measurement of 0.99 +/- 0.14 improves on the precision of the ATLAS measurement at root s = 7 and 8 TeV by a factor of two. Measurements of gluon-gluon fusion and vector-boson fusion productions yield signal strengths compatible with the Standard Model prediction. Measurements of simplified template cross sections, designed to quantify the different Higgs boson production processes in specific regions of phase space, are reported. The cross section for the production of the Higgs boson decaying to two isolated photons in a fiducial region closely matching the experimental selection of the photons is measured to be 55 +/- 10 fb, which is in good agreement with the Standard Model prediction of 64 +/- 2 fb. Furthermore, cross sections in fiducial regions enriched in Higgs boson production in vector-boson fusion or in association with large missing transverse momentum, leptons or top-quark pairs are reported. Differential and double-differential measurements are performed for several variables related to the diphoton kinematics as well as the kinematics and multiplicity of the jets produced in association with a Higgs boson. These differential cross sections are sensitive to higher order QCD corrections and properties of the Higgs boson, such as its spin and CP quantum numbers. No significant deviations from a wide array of Standard Model predictions are observed. Finally, the strength and tensor structure of the Higgs boson interactions are investigated using an effective Lagrangian, which introduces additional CP-even and CP-odd interactions. No significant new physics contributions are observed. KW - Differential Cross-Sections KW - QCD Corrections KW - Search KW - Model KW - NNLO KW - Particle data analysis KW - Particle properties KW - Photons KW - Higgs bosons Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226733 VL - 98 ER - TY - JOUR T1 - Measurements of t(t)over-bar differential cross-sections of highly boosted top quarks decaying to all-hadronic final states in \(pp\) collisions at root \(s\)=13 Te V using the ATLAS detector JF - Physical Review D N2 - Measurements are made of differential cross-sections of highly boosted pair-produced top quarks as a function of top-quark and t (t) over bar system kinematic observables using proton-proton collisions at a center-of-mass energy of root s = 13 TeV. The data set corresponds to an integrated luminosity of 36.1 fb(-1), recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Events with two large-radius jets in the final state, one with transverse momentum p(T) > 500 GeV and a second with p(T) > 350 GeV, are used for the measurement. The top-quark candidates are separated from the multijet background using jet substructure information and association with a b-tagged jet. The measured spectra are corrected for detector effects to a particle-level fiducial phase space and a parton-level limited phase space, and are compared to several Monte Carlo simulations by means of calculated chi(2) values. The cross-section for t (t) over bar production in the fiducial phase-space region is 292 +/- 7(stat) +/- 71(syst) tb, to be compared to the theoretical prediction of 384 +/- 36 fb. KW - Parton Distributions KW - Particle data analysis KW - Bayesian methods KW - Top quark KW - Quarks KW - Strong interaction KW - Quantum chromodynamics KW - Perturbative QCD Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226771 VL - 98 ER - TY - JOUR T1 - Search for supersymmetry in final states with charm jets and missing transverse momentum in 13 TeV \(pp\) collisions with the ATLAS detector JF - Journal of High Energy Physics N2 - A search for supersymmetric partners of top quarks decaying as (t) over tilde (1) -> c (chi) over tilde (0)(1)and supersymmetric partners of charm quarks decaying as (c) over tilde (1) -> c (chi) over tilde (0)(1) where (chi) over tilde (0)(1) is the lightest neutralino, is presented. The search uses 36.1 fb(-1) pp collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS experiment at the Large Hadron Collider and is performed in final states with jets identified as containing charm hadrons. Assuming a 100% branching ratio to c (chi) over tilde (0)(1), top and charm squarks with masses up to 850 GeV are excluded at 95% confidence level for a massless lightest neutralino. For m (t) over tilde (1,(c) over tilde1) - m((chi) over tilde 10)< 100 GeV, top and charm squark masses up to 500 GeV are excluded. KW - Hadron-Hadron scattering (experiments) KW - Parton Distributions KW - Extension KW - Squark KW - Decay Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226752 VL - 09 ER - TY - JOUR T1 - Search for Low-Mass Dijet Resonances Using Trigger-Level Jets with the ATLAS Detector in \(pp\) Collisions at root \(s\)=13 TeV JF - Physical Review Letters N2 - Searches for dijet resonances with sub-TeV masses using the ATLAS detector at the Large Hadron Collider can be statistically limited by the bandwidth available to inclusive single-jet triggers, whose data-collection rates at low transverse momentum are much lower than the rate from standard model multijet production. This Letter describes a new search for dijet resonances where this limitation is overcome by recording only the event information calculated by the jet trigger algorithms, thereby allowing much higher event rates with reduced storage needs. The search targets low-mass dijet resonances in the range 450-1800 GeV. The analyzed data set has an integrated luminosity of up to 29.3 fb(-1) and was recorded at a center-of-mass energy of 13 TeV. No excesses are found; limits are set on Gaussian-shaped contributions to the dijet mass distribution from new particles and on a model of dark-matter particles with axial-vector couplings to quarks. KW - Distributions KW - Hadron colliders KW - Weakly interacting massive particles KW - Quark & gluon jets KW - Particle dark matter Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226725 VL - 121 ER - TY - JOUR T1 - Measurement of colour flow using jet-pull observables in t(t)over-bar events with the ATLAS experiment at root \(s\)=13TeV JF - European Physical Journal C N2 - Previous studies have shown that weighted angular moments derived from jet constituents encode the colour connections between partons that seed the jets. This paper presents measurements of two such distributions, the jet-pull angle and jet-pull magnitude, both of which are derived from the jet-pull angular moment. The measurement is performed in delivered by the Large Hadron Collider. The observables are measured for two dijet systems, corresponding to the colour-connected daughters of the Wboson and the two b-jets from the top-quark decays, which are not expected to be colour connected. To allow the comparison of the measured distributions to colour model predictions, the measured distributions are unfolded to particle level, after correcting for experimental effects introduced by the detector. While good agreement can be found for some combinations of predictions and observables, none of the predictions describes the data well across all observables. KW - Quark pair procuction KW - Parton distributions KW - Hadron colliders KW - Cross-section Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226039 VL - 78 ER - TY - JOUR T1 - Prompt and non-prompt \(J\)/\(ψ\) and \(ψ\)(2S) suppression at high transverse momentum in 5.02 TeV Pb+Pb collisions with the ATLAS experiment JF - European Physical Journal C N2 - A measurement of J/psi and psi(2S) production is presented. It is based on a data sample from Pb+Pb collisions at root s(NN) = 5.02 TeV and pp collisions at root s = 5.02 TeV recorded by the ATLAS detector at the LHC in 2015, corresponding to an integrated luminosity of 0.42 nb(-1) and 25 pb(-1) in Pb+Pb and pp, respectively. The measurements of per-event yields, nuclear modification factors, and non-prompt fractions are performed in the dimuon decay channel for 9 < p(T)(mu mu) < 40 GeV in dimuon transverse momentum, and -2 < y(mu mu) < 2 in rapidity. Strong suppression is found in Pb+Pb collisions for both prompt and non-prompt J/psi, increasing with event centrality. The suppression of prompt psi(2S) is observed to be stronger than that of J/psi, while the suppression of non-prompt psi(2S) is equal to that of the non-prompt J/psi within uncertainties, consistent with the expectation that both arise from b-quarks propagating through the medium. Despite prompt and non-prompt J/psi arising from different mechanisms, the dependence of their nuclear modification factors on centrality is found to be quite similar. KW - PB-PB Collisions KW - Quarkonium Production KW - Monte-Carlo KW - Nuclear KW - Charmonia KW - Rapidity Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226056 VL - 78 ER - TY - JOUR T1 - Search for new phenomena using the invariant mass distribution of same-flavour opposite-sign dilepton pairs in events with missing transverse momentum in root \(s\)=13 TeV \(pp\) collisions with the ATLAS detector JF - European Physical Journal C N2 - A search for new phenomena in final states containing an e(+)e(-) or m(+)m(-) pair, jets, and large missing transverse momentum is presented. This analysis makes use of proton-proton collision data with an integrated luminosity of 36.1 fb(-1), collected during 2015 and 2016 at a centre of-mass energy Os = 13 TeV with the ATLAS detector at the Large Hadron Collider. The search targets the pair production of supersymmetric coloured particles (squarks or gluinos) and their decays into final states containing an e(+)e(-) or m(+)m(-) pair and the lightest neutralino ((c) over tilde (0)(1)) via one of two next-to-lightest neutralino ((c) over tilde (0)(2)) decay mechanisms: (c) over tilde (0)(2) Z (c) over tilde (0)(1), where the Z boson decays leptonically leading to a peak in the dilepton invariant mass distribution around the Z boson mass; and (c) over tilde (0)(2) l(+)1(-) (c) over tilde (0)(1) with no intermediate l(+)l(-) resonance, yielding a kinematic endpoint in the dilepton invariant mass spectrum. The data are found to be consistent with the Standard Model expectation. Results are interpreted using simplified models, and exclude gluinos and squarks with masses as large as 1.85 and 1.3 TeV at 95% confidence level, respectively. KW - Parton Distributions KW - Gluino Production KW - ++ KW - Extension KW - Energy KW - Squark KW - Supersymmetry KW - Physics KW - Decay Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226109 VL - 78 ER - TY - JOUR T1 - Measurement of differential cross-sections of a single top quark produced in association with a \(W\) boson at root \(s\)=13TeV with ATLAS JF - European Physical Journal C N2 - The differential cross-section for the production of a W boson in association with a top quark is measured for several particle-level observables. The measurements are performed using 36.1 fb(-1) of pp collision data collected with the ATLAS detector at the LHC in 2015 and 2016. Differential cross-sections are measured in a fiducial phase space defined by the presence of two charged leptons and exactly one jet matched to a b-hadron, and are normalised with the fiducial cross-section. Results are found to be in good agreement with predictions from several Monte Carlo event generators. KW - Parton Distributions Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226718 VL - 78 ER - TY - JOUR T1 - Search for the Decay of the Higgs Boson to Charm Quarks with the ATLAS Experiment JF - Physical Review Letters N2 - A direct search for the standard model Higgs boson decaying to a pair of charm quarks is presented. Associated production of the Higgs and Z bosons, in the decay mode ZH -> l(+)l(-) cc is studied. A data set with an integrated luminosity of 36.1 fb(-1) of pp collisions at root s = 13TeV recorded by the ATLAS experiment at the LHC is used. The H -> cc signature is identified using charm-tagging algorithms. The observed (expected) upper limit on sigma(pp -> ZH) x B(H -> cc) is 2.7 (3.9(-2.1)(+2.1) ) pb at the 95% confidence level for a Higgs boson mass of 125 GeV, while the standard model value is 26 fb. KW - Programm KW - Spontaneous symmetry breaking KW - Higgs bosons KW - Charm quark Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226523 VL - 120 ER - TY - JOUR T1 - Search for a Structure in the B-s(0) π\(^{±}\) Invariant Mass Spectrum with the ATLAS Experiment JF - Physical Review Letters N2 - A search for the narrow structure, X(5568), reported by the DO Collaboration in the decay sequence X -> B-s(0) pi +/-, B-s(0) -> J/psi phi, is presented. The analysis is based on a data sample recorded with the ATLAS detector at the LHC corresponding to 4.9 fb(-1) of pp collisions at 7 TeV and 19.5 fb(-1)at 8 TeV. No significant signal was found. Upper limits on the number of signal events, with properties corresponding to those reported by DO, and on the A production rate relative to B-s(0) mesons, rho x, were determined at 95% confidence level. The results are N(X) < 382 and rho x <0.015 for B-s(0) mesons with transverse momenta above 10 GeV and N(X) < 356 and rho(x) < 0.016 for transverse momenta above 15 GeV. Limits are also set for potential B-s(0) pi(+) resonances in the mass range 5550 to 5700 MeV. KW - Mass Spectrum KW - Parton Distributions KW - Decay sequence KW - Analysis KW - MASS KW - Hadron colliders KW - Exotic mesons Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226539 VL - 120 ER - TY - JOUR T1 - Search for High-Mass Resonances Decaying to τν in \(pp\) Collisions at root \(s\)=13 TeV with the ATLAS Detector JF - Physical Review Letters N2 - A search for high-mass resonances decaying to tau nu using proton-proton collisions at root s = 13 TeV produced by the Large Hadron Collider is presented. Only tau-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb(-1). No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible tau nu production cross section. Heavy W' bosons with masses less than 3.7 TeV in the sequential standard model and masses less than 2.2-3.8 TeV depending on the coupling in the nonuniversal Go(221) model are excluded at the 95% credibility level. KW - Proton-Proton Collisions KW - Parton Ditributions KW - Cross-Section KW - ++ KW - Lepton KW - Hadron colliders KW - Hypothetical gauge bosons KW - Particle production KW - Extensions of gauge sector Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226556 VL - 120 ER - TY - JOUR T1 - Search for pair production of Higgsinos in final states with at least three \(b\)-tagged jets in root \(s\)=13 TeV \(pp\) collisions using the ATLAS detector JF - Physical Review D N2 - A search for pair production of the supersymmetric partners of the Higgs boson (higgsinos (H) over tilde) in gaugemediated scenarios is reported. Each higgsino is assumed to decay to a Higgs boson and a gravitino. Two complementary analyses, targeting high- and low-mass signals, are performed to maximize sensitivity. The two analyses utilize LHC pp collision data at a center-of-mass energy root s = 13 TeV, the former with an integrated luminosity of 36.1 fb(-1) and the latter with 24.3 fb(-1), collected with the ATLAS detector in 2015 and 2016. The search is performed in events containing missing transverse momentum and several energetic jets, at least three of which must be identified as b-quark jets. No significant excess is found above the predicted background. Limits on the cross section are set as a function of the mass of the <(Hover tilde> in simplified models assuming production via mass-degenerate higgsinos decaying to a Higgs boson and a gravitino. Higgsinos with masses between 130 and 230 GeV and between 290 and 880 GeV are excluded at the 95% confidence level. Interpretations of the limits in terms of the branching ratio of the higgsino to a Z boson or a Higgs boson are also presented, and a 45% branching ratio to a Higgs boson is excluded for m(<(Hover tilde>) approximate to 400 GeV. KW - Gluino Production KW - Supersymmetry KW - Extension KW - Squark KW - Predictions KW - Supersymmetric models KW - Hierarchy problem KW - Extensions of Higgs sector Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226010 VL - 98 ER - TY - JOUR T1 - Search for heavy resonances decaying to a photon and a hadronically decaying \({Z/W/H}\) boson in \(pp\) collisions at root \(s\)=13 TeV with the ATLAS detector JF - Physical Review D N2 - Many extensions of the Standard Model predict new resonances decaying to a Z, W, or Higgs boson and a photon. This paper presents a search for such resonances produced in pp collisions at root s = 13 TeV using a data set with an integrated luminosity of 36.1 fb(-1) collected by the ATLAS detector at the LHC. The Z/W/H bosons are identified through their decays to hadrons. The data are found to be consistent with the Standard Model expectation in the entire investigated mass range. Upper limits are set on the production cross section times branching fraction for resonance decays to Z.W + gamma in the mass range from 1.0 to 6.8 TeV and for the first time into H + gamma in the mass range from 1.0 to 3.0 TeV. KW - Parton Distributions KW - Gamma KW - Electroweak interaction KW - Higgs bosons Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226079 VL - 98 ER - TY - JOUR T1 - Search for top squarks decaying to tau sleptons in \(pp\) collisions at root \(s\)=13 TeV with the ATLAS detector JF - Physical Review D N2 - A search for direct pair production of top squarks in final states with two tau leptons, b-jets, and missing transverse momentum is presented. The analysis is based on proton-proton collision data at root s = 13 TeV corresponding to an integrated luminosity of 36.1 fb(-1) recorded with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. Two exclusive channels with either two hadronically decaying tau leptons or one hadronically and one leptonically decaying tau lepton are considered. No significant deviation from the Standard Model predictions is observed in the data. The analysis results are interpreted in terms of model-independent limits and used to derive exclusion limits on the masses of the top squark (t) over tilde (1) and the tau slepton (tau) over tilde (1) in a simplified model of supersymmetry with a nearly massless gravitino. In this model, masses up to m((t) over tilde (1)) = 1.16 TeV and m ((tau) over tilde (1)) = 1.00 TeV are excluded at 95% confidence level. KW - Parton Distributions KW - Measuring Masses KW - Extension KW - Physics KW - Energy KW - Supersymmetric models KW - Superpartners KW - Tau leptons KW - Top quark KW - Particle data analysis Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226080 VL - 98 ER - TY - JOUR T1 - Search for photonic signatures of gauge-mediated supersymmetry in 13 TeV \(pp\) collisions with the ATLAS detector JF - Physical Review D N2 - A search is presented for photonic signatures, motivated by generalized models of gauge-mediated supersymmetry breaking. This search makes use of proton-proton collision data at root s = 13 TeV corresponding to an integrated luminosity of 36.1 fb(-1) recorded by the ATLAS detector at the LHC, and it explores models dominated by both strong and electroweak production of supersymmetric partner states. Experimental signatures incorporating an isolated photon and significant missing transverse momentum are explored. These signatures include events with an additional photon or additional jet activity not associated with any specific underlying quark flavor. No significant excess of events is observed above the Standard Model prediction, and 95% confidence-level upper limits of between 0.083 and 0.32 fb are set on the visible cross section of contributions from physics beyond the Standard Model. These results are interpreted in terms of lower limits on the masses of gluinos, squarks, and gauginos in the context of generalized models of gauge-mediated supersymmetry, which reach as high as 2.3 TeV for strongly produced and 1.3 TeV for weakly produced supersymmetric partner pairs. KW - Gluino production KW - Supersymmetric models KW - Hypothetical particle physics models KW - Fortran code KW - Extension KW - Squark KW - Breaking KW - Decays KW - Model KW - Weak Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226510 VL - 97 ER - TY - JOUR T1 - Search for the standard model Higgs boson produced in association with top quarks and decaying into a b(b)overbar pair in \(pp\) collisions at root \(s\)=13 TeV with the ATLAS detector JF - Physical Review D N2 - A search for the standard model Higgs boson produced in association with a top-quark pair, t(t)overbarH, is presented. The analysis uses 36.1 fb(-1) of pp collision data at root s = 13 TeV collected with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The search targets the H -> b(b)overbar decay mode. The selected events contain either one or two electrons or muons from the top-quark decays, and are then categorized according to the number of jets and how likely these are to contain b-hadrons. Multivariate techniques are used to discriminate between signal and background events, the latter being dominated by ft + jets production. For a Higgs boson mass of 125 GeV, the ratio of the measured t(t)overbarH signal cross-section to the standard model expectation is found to be mu = 0.84(-0.61)(+0.64). A value of mu greater than 2.0 is excluded at 95% confidence level (C.L.) while the expected upper limit is mu < 1.2 in the absence of a t(t)overbarH signal. KW - ++ KW - Symmetries KW - program KW - MASS KW - spontaneous symmetry breaking KW - Higgs bosons KW - Top quark Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226545 VL - 97 IS - 7 ER - TY - JOUR T1 - Evidence for the associated production of the Higgs boson and a top quark pair with the ATLAS detector JF - Physical Review D N2 - A search for the associated production of the Higgs boson with a top quark pair (tt (b) over barH) is reported. The search is performed in multilepton final states using a data set corresponding to an integrated luminosity of 36.1 fb(-1) of proton-proton collision data recorded by the ATLAS experiment at a center-of-mass energy root s = 13 TeV at the Large Hadron Collider. Higgs boson decays to WW*, tau tau, and ZZ* are targeted. Seven final states, categorized by the number and flavor of charged-lepton candidates, are examined for the presence of the Standard Model Higgs boson with a mass of 125 GeVand a pair of top quarks. An excess of events over the expected background from Standard Model processes is found with an observed significance of 4.1 standard deviations, compared to an expectation of 2.8 standard deviations. The best fit for the (tt (b) over barH) production cross section is sot (tt (b) over barH) = 790(-210)(+230) fb, in agreement with the Standard Model prediction of 507(-50)(+35) fb. The combination of this result with other tt (b) over barH searches from the ATLAS experiment using the Higgs boson decay modes to b (b) over bar, gamma gamma and ZZ* -> 4l, has an observed significance of 4.2 standard deviations, compared to an expectation of 3.8 standard deviations. This provides evidence for the tt (b) over barH production mode. KW - Production cross-section KW - spontaneous symmetry breaking KW - Higgs bosons KW - Top quark KW - Parton distributions KW - pp collisions KW - Monte-Carlo KW - 8 TEV KW - Root s=7 KW - search KW - decay KW - model KW - symmetries Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226569 VL - 97 ER - TY - JOUR T1 - Search for R-parity-violating supersymmetric particles in multi-jet final states produced in \({p-p}\) collisions at root \(s\)=13 TeV using the ATLAS detector at the LHC JF - Physics Letters B N2 - Results of a search for gluino pair production with subsequent R-parity-violating decays to quarks are presented. This search uses 36.1 fb(-1) of data collected by the ATLAS detector in proton-proton collisions with a centre-of-mass energy of root s = 13 TeV at the LHC. The analysis is performed using requirements on the number of jets and the number of jets tagged as containing a b-hadron as well as a topological observable formed by the scalar sum of masses of large-radius jets in the event. No significant excess above the expected Standard Model background is observed. Limits are set on the production of gluinos in models with the R-parity-violating decays of either the gluino itself (direct decay) or the neutralino produced in the R-parity-conserving gluino decay (cascade decay). In the gluino cascade decay model, gluino masses below 1850 GeV are excluded for 1000 GeV neutralino mass. For the gluino direct decay model, the 95% confidence level upper limit on the cross section times branching ratio varies between 0.80 fb at m((g) over tilde) = 900 GeV and 0.011 fb at m((g) over tilde) = 1800 GeV. (c) 2018 The Author. Published by Elsevier B.V. This is an open access article under the CC BY license. KW - Gluino Production KW - Extension KW - Decay KW - Squark Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226047 VL - 785 ER - TY - JOUR T1 - Measurement of the Higgs boson mass in the \(H\) -> \({ZZ}\)* -> 4l and \(H\) -> \({γγ}\) channels with root \(s\)=13 TeV \({pp}\) collisions using the ATLAS detector JF - Physics Letters B N2 - The mass of the Higgs boson is measured in the H -> ZZ* -> 4l and in the H -> gamma gamma decay channels with 36.1 fb(-1) of proton-proton collision data from the Large Hadron Collider at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector in 2015 and 2016. The measured value in the H -> ZZ* -> 4l channel is m(H)(ZZ*) = 124.79 +/- 0.37 GeV, while the measured value in the H -> gamma gamma channel is m(H)(gamma gamma) = 124.93 +/- 0.40 GeV. Combining these results with the ATLAS measurement based on 7 and 8 TeV proton-proton collision data yields a Higgs boson mass of m(H) = 124.97 +/- 0.24 GeV. (c) 2018 The Author. Published by Elsevier B.V. KW - proton-proton collision KW - Hadron Collider KW - Higgs boson mass KW - gamma gamma channel Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226065 VL - 784 ER - TY - JOUR T1 - Search for a heavy Higgs boson decaying into a \(Z\) boson and another heavy Higgs boson in the \({llbb}\) final state in \({pp}\) collisions at root \(s\)=13 TeV with the ATLAS detector JF - Physics Letters B N2 - A search for a heavy neutral Higgs boson, A, decaying into a Z boson and another heavy Higgs boson, H, is performed using a data sample corresponding to an integrated luminosity of 36.1 fb(-1) from proton-proton collisions at root s = 13 TeV recorded in 2015 and 2016 by the ATLAS detector at the Large Hadron Collider. The search considers the Z boson decaying to electrons or muons and the H boson into a pair of b-quarks. No evidence for the production of an A boson is found. Considering each production process separately, the 95% confidence-level upper limits on the pp -> A -> ZH production cross-section times the branching ratio H -> bb are in the range of 14-830 fb for the gluon-gluon fusion process and 26-570 fb for the b-associated process for the mass ranges 130-700 GeV of the H boson and 230-800 GeV of the A boson. The results are interpreted in the context of two-Higgs-doublet models. (C) 2018 Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP(3). KW - Hadron Colliders KW - Parton Distributions KW - MASS Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226098 VL - 783 ER -