TY  - JOUR
A1  - Brunkhorst-Kanaan, Nathalie
A1  - Trautmann, Sandra
A1  - Schreiber, Yannick
A1  - Thomas, Dominique
A1  - Kittel-Schneider, Sarah
A1  - Gurke, Robert
A1  - Geisslinger, Gerd
A1  - Reif, Andreas
A1  - Tegeder, Irmgard
T1  - Sphingolipid and endocannabinoid profiles in adult attention deficit hyperactivity disorder
JF  - Biomedicines
N2  - Genes encoding endocannabinoid and sphingolipid metabolism pathways were suggested to contribute to the genetic risk towards attention deficit hyperactivity disorder (ADHD). The present pilot study assessed plasma concentrations of candidate endocannabinoids, sphingolipids and ceramides in individuals with adult ADHD in comparison with healthy controls and patients with affective disorders. Targeted lipid analyses of 23 different lipid species were performed in 71 mental disorder patients and 98 healthy controls (HC). The patients were diagnosed with adult ADHD (n = 12), affective disorder (major depression, MD n = 16 or bipolar disorder, BD n = 6) or adult ADHD with comorbid affective disorders (n = 37). Canonical discriminant analysis and CHAID analyses were used to identify major components that predicted the diagnostic group. ADHD patients had increased plasma concentrations of sphingosine-1-phosphate (S1P d18:1) and sphinganine-1-phosphate (S1P d18:0). In addition, the endocannabinoids, anandamide (AEA) and arachidonoylglycerol were increased. MD/BD patients had increased long chain ceramides, most prominently Cer22:0, but low endocannabinoids in contrast to ADHD patients. Patients with ADHD and comorbid affective disorders displayed increased S1P d18:1 and increased Cer22:0, but the individual lipid levels were lower than in the non-comorbid disorders. Sphingolipid profiles differ between patients suffering from ADHD and affective disorders, with overlapping patterns in comorbid patients. The S1P d18:1 to Cer22:0 ratio may constitute a diagnostic or prognostic tool.
KW  - attention deficit hyperactivity disorder
KW  - endocannabinoids
KW  - ceramides
KW  - bipolar disorder
KW  - major depression
KW  - tandem mass spectrometry
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-246080
SN  - 2227-9059
VL  - 9
IS  - 9
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Sibylle
A1  - Schumacher, Fabian
A1  - Wigger, Dominik
A1  - Schöl, Marie
A1  - Waghmare, Trushnal
A1  - Schlegel, Jan
A1  - Seibel, Jürgen
A1  - Kleuser, Burkhard
T1  - Sphingolipids: effectors and Achilles heals in viral infections?
JF  - Cells
N2  - As viruses are obligatory intracellular parasites, any step during their life cycle strictly depends on successful interaction with their particular host cells. In particular, their interaction with cellular membranes is of crucial importance for most steps in the viral replication cycle. Such interactions are initiated by uptake of viral particles and subsequent trafficking to intracellular compartments to access their replication compartments which provide a spatially confined environment concentrating viral and cellular components, and subsequently, employ cellular membranes for assembly and exit of viral progeny. The ability of viruses to actively modulate lipid composition such as sphingolipids (SLs) is essential for successful completion of the viral life cycle. In addition to their structural and biophysical properties of cellular membranes, some sphingolipid (SL) species are bioactive and as such, take part in cellular signaling processes involved in regulating viral replication. It is especially due to the progress made in tools to study accumulation and dynamics of SLs, which visualize their compartmentalization and identify interaction partners at a cellular level, as well as the availability of genetic knockout systems, that the role of particular SL species in the viral replication process can be analyzed and, most importantly, be explored as targets for therapeutic intervention.
KW  - glycosphingolipids
KW  - ceramides
KW  - sphingosine 1-phosphate
KW  - sphingomyelinase
KW  - HIV
KW  - SARS-CoV-2
KW  - measles
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-245151
SN  - 2073-4409
VL  - 10
IS  - 9
ER  -