TY - CHAP A1 - Anders, Fritz A1 - Schartl, Manfred A1 - Barnekow, Angelika T1 - Xiphophorus as an in vivo model for studies on oncogenes N2 - The capacity of Xiphophorus to develop neoplasia can be formally assigned to a "tumor gene" (Tu), which appears to be a normal part of the genome of all individuals. The wild fish have evolved population-specific and cell type-specific systems of regulatory genes (R) for Tu that protect the fish from neoplasia. Hybridization of members of different wild populations in the laborstory followed by treatment of the hybrids with carcinogens led to disintegration of the R systems permitting excessive expression of Tu and thus resulting in neoplasia. Certain hybrids developed neoplasia even spontaneously. Observations on the genuine phenotypic effect of the derepressed Tu in the early embryo indicated an essential normal function of this oncogene in cell differentiation, proliferation and cell-cell communication. Tu appeared to be indispensable in the genome but may also be present in accessory copics. Recently, c-src, the cellular homolog of the Rous sarcoma virus oncogene v-src, was detected in Xiphophorus. The protein product of c-src, pp60c-src, was identified and then examined by its associated kinase activity. This pp60c-src was found in all individuals tested, but, depending on the genotype, its kinase activity was different. The genetic characters of c-src, such as linkage relations, dosage relations, expression, etc., correspond to those of Tu. From a systematic study which showed that pp60c-src was present in all metazoa tested ranging from mammals down to sponges, we concluded that c-src has evolved with the multicellular organization of animals. Neoplasia of animals and humans is a characteristic closely related to this evolution. Our data showed that small aquariurn fish, besides being used successfully because they are time-, space-, and money-saving systems for carcinogenicity testing, are also highly suitable for basic studies on neoplasia at the populational, morphological, developmental, cell biological, and molecular levels. KW - Schwertkärpfling KW - In vivo KW - Onkogen Y1 - 1984 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86398 ER - TY - CHAP A1 - Heiser, A. A1 - Ulrichs, Karin A1 - Eckstein, V. A1 - Müller-Ruchholtz, W. T1 - Xenogeneic Cellular Response of Human Lymphocytes Against Porcine Lymphocytes and Isolated Pancreatic Islets N2 - no abstract available Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45479 ER - TY - CHAP A1 - Schmitz, Barbara T1 - War, violence and Tyrannicide in the Book of Judith N2 - No abstract available KW - Judit KW - Gewalt KW - Krieg KW - Tyrannenmord KW - Judith KW - Violence KW - War KW - Tyrannicide Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-67058 ER - TY - CHAP A1 - Schneider, Wolfgang A1 - Weinert, Franz E. T1 - Universal trends and individual differences in memory development N2 - No abstract available. KW - Gedächtnisbildung Y1 - 1989 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86518 ER - TY - CHAP A1 - Trendelenburg, M. F. A1 - Franke, Werner W. A1 - Spring, H. A1 - Scheer, Ulrich T1 - Ultrastructure of transcription in the nucleoli of the green algae Acetabularia major and A. mediterranea N2 - No abstract available Y1 - 1975 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33779 ER - TY - CHAP A1 - Eckstein, V. A1 - Ulrichs, Karin A1 - Meincke, G. A1 - Mülller-Ruchholtz, W. T1 - Transplantation of Diabetic Patients With Xenogeneic Pancreatic Islets Has to Consider Natural Xenophile Antibodies (NXA) In Patients Sera As a Major Obstacle to Success N2 - No abstract available KW - Immunbiologie Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45707 ER - TY - CHAP A1 - Scheer, Ulrich A1 - Franke, Werner W. T1 - Transcriptional complexes of nucleolar genes N2 - No abstract available Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41072 ER - TY - CHAP A1 - Rethwilm, Axel A1 - Baunach, Gerald A1 - Mori, Kazuyasu A1 - ter Meulen, Volker T1 - Transactivation of HIV by human spumaretrovirus N2 - To study the activation of HIV by human spumaretrovirus (HSRV) the long terminal repeats (LTRs) of HSRV, HIVl and HIV2 were examined with respect to their ability to function as transcriptional promoters in virus infected and uninfected cells. Transient transfections using plasmids in which the L TRs of the three viruses were coupled to the bacterial chloramphenicol acetyltransferase (CA T) gene revealed (i) the level of cat gene expression directed by the HSRV LTR was markedly increased in HSRV infected cells compared to uninfected cells, (ii) cat gene expression driven by the HIV1 LTR, but not by the HIV2 LTR could be enhanced upon HSRV infection, whereas (iii) neither in HIV1 nor in HIV2 infected cells an effect on HSRV LTR driven cat geneexpression was detected. KW - HIV Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86436 ER - TY - CHAP A1 - Abendschein, Robin A1 - Desai, Shital A1 - Astell, Arlene J. T1 - Towards Accessibility Guidelines for the Metaverse : A Synthesis of Recommendations for People Living With Dementia T2 - Conference on Human Factors in Computing Systems (CHI’23) : Workshop "Towards an Inclusive and Accessible Metaverse" N2 - Given the growing interest of corporate stakeholders in Metaverse applications, there is a need to understand accessibility of these technologies for marginalized populations such as people living with dementia to ensure inclusive design of Metaverse applications. We assessed the accessibility of extended reality technology for people living with mild cognitive impairment and dementia to develop accessibility guidelines for these technologies. We used four strategies to synthesize evidence for barriers and facilitators of accessibility: (1) Findings from a non-systematic literature review, (2) guidelines from well-researched technology, (3) exploration of selected mixed reality technologies, and (4) observations from four sessions and video data of people living with dementia using mixed reality technologies. We utilized template analysis to develop codes and themes towards accessibility guidelines. Future work can validate our preliminary findings by applying them on video recordings or testing them in experiments. KW - CHI Conference KW - Accessibility KW - Metaverse KW - extended reality KW - dementia KW - cognitive impairment KW - Human-centered computing / Access KW - Human-centered computing / Human computer interaction (HCI) / Interaction paradigms / Mixed / augmented reality KW - Human-centered computing / Human computer interaction (HCI) / Interaction paradigms / Virtual reality KW - Human-centered computing / Human computer interaction (HCI) / Interactiondevices KW - Human-centered computing / Human computerinteraction (HCI) / Interaction techniques Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-320199 UR - https://sites.google.com/view/accessiblemetaverse ER - TY - CHAP A1 - Schneider, Wolfgang A1 - Weinert, Franz E. T1 - The role of knowledge, strategies, and aptitudes in cognitive Performance: Concluding Comments N2 - No abstract available. KW - Kognitive Entwicklung KW - Begabung Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87190 ER - TY - CHAP A1 - Schneider, Wolfgang A1 - Weinert, Franz E. T1 - The role of knowledge, strategies, and aptitudes in cognitive performance : concluding comments N2 - No abstract available. KW - Intelligenzleistung KW - Wissen KW - Begabung Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86554 ER - TY - CHAP A1 - Kaitschick, J. A1 - Ulrichs, K. A1 - Müller-Ruchholtz, W. T1 - The New Immunosuppressant Leflunomide Appears To Be a Potent Inhibitor of Humoral Xeno Sensitization N2 - No abstract available KW - Immunbiologie Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45727 ER - TY - CHAP A1 - Axelrod, V. D. A1 - Gorboulev, Valentin G. A1 - Kutateladze, T. V. A1 - Barciszewski, J. A1 - Bayev, A. A. T1 - The new approach to tRNA primary structure determination : the primary structure of valine tRNA\(^{Val}_{2b}\) N2 - The new combination of TLC and high voltage electrophoresis on cooling plate is described.We have applied this technique to study of primary structure of tRNA.Preliminary sequence of baker's yeast tRNA^Val_2b is described. New approach to preparation of large tRNA fragments is demonstrated. KW - RNS Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50920 ER - TY - CHAP A1 - Werner, Rudolf A. A1 - Marcus, Charles A1 - Sheikhbahaei, Sara A1 - Higuchi, Takahiro A1 - Solnes, Lilja B. A1 - Rowe, Steven P. A1 - Buck, Andreas K. A1 - Lapa, Constantin A1 - Javadi, Mehrbod S. T1 - The Impact of Ageing on Dopamine Transporter Imaging T2 - Journal of Nuclear Medicine N2 - No abstract available. KW - Parkinson-Krankheit KW - Parkinson KW - Parkinson Disease KW - DaTscan KW - Ioflupane KW - SPECT KW - molecular imaging KW - ageing Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-162213 UR - http://jnm.snmjournals.org/content/59/supplement_1/1646.abstract SN - 0161-5505 N1 - This research was originally published in JNM. Rudolf A. Werner, Charles Marcus, Sara Sheikhbahaei, Takahiro Higuchi, Lilja B. Solnes, Steven P. Rowe, Andreas K. Buck, Constantin Lapa, Mehrbod S. Javadi. The Impact of Ageing on Dopamine Transporter Imaging. J Nucl Med. May 1, 2018; vol. 59 no. supplement 1:1646. © SNMMI. VL - 59 IS - Supplement No 1 SP - 1646 ER - TY - CHAP A1 - Werner, Rudolf A. A1 - Chen, Xinyu A1 - Hirano, Mitsuru A1 - Nose, Naoko A1 - Lapa, Constantin A1 - Javadi, Mehrbod S. A1 - Higuchi, Takahiro T1 - The Impact of Ageing on [\(^{11}\)C]meta-Hydroxyephedrine Uptake in the Rat Heart T2 - Journal of Nuclear Medicine N2 - No abstract available. KW - Positronen-Emissions-Tomografie KW - moycardial sympathetic innervation KW - Positronen-Emissions-Tomografie KW - positron emission tomography KW - PET KW - 11C-HED KW - hydroxyephedrine KW - ageing Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-162228 UR - http://jnm.snmjournals.org/content/59/supplement_1/100.abstract SN - 0161-5505 VL - 59 IS - Supplement No 1 ER - TY - CHAP A1 - Heiser, A. A1 - Ulrichs, Karin A1 - Eckstein, V. A1 - Müller-Ruchholtz, W. T1 - The Human Cell Mediated Response to Xenogeneic (Porcine) Transplantation Antigen Depends on the Stimulator Cell Compartment N2 - No abstract available Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45670 ER - TY - CHAP A1 - Fiala, Brigitte A1 - Federle, W. A1 - Maschwitz, U. A1 - Azarae, Idris T1 - The first myrmecophytic 2-partner-system in the genus Macaranga: The association between Macaranga puncticulata and a Componotus (Colobopsis) in Malaysia N2 - No abstract available KW - Biologie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-55144 ER - TY - CHAP A1 - Gotz, R. A1 - Schartl, Manfred T1 - The conservation of neurotrophic factors during vertebrate evolution N2 - No abstract available KW - Physiologische Chemie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61964 ER - TY - CHAP A1 - Schneider, Wolfgang T1 - The "what" and "how" of development: Really two separate research agendas? N2 - No abstract available. KW - Entwicklungspsychologie Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86630 ER - TY - CHAP ED - Middelhoff, Frederike ED - Schönbeck, Sebastian ED - Borgards, Roland ED - Gersdorf, Catrin T1 - Texts, Animals, Environments: Zoopoetics and Ecopoetics N2 - Texts, Animals, Environments. Zoopoetics and Ecopoetics probes the multiple links between ecocriticism and animal studies, assessing the relations between animals, environments and poetics. While ecocriticism usually relies on a relational approach to explore phenomena related to the environment or ecology more broadly, animal studies tends to examine individual or species-specific aspects. As a consequence, ecocriticism concentrates on ecopoetical, animal studies on zoopoetical elements and modes of representation in literature (and the arts more generally). Bringing key concepts of ecocriticism and animal studies into dialogue, the volume explores new ways of thinking about and reading texts, animals, and environments – not as separate entities but as part of the same collective. KW - Ecocriticism KW - Animal Studies KW - Cultural Animal Studies KW - Human-Animal Studies KW - Environmental Humanities KW - Literary Studies KW - Cultural Studies Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-177209 UR - https://www.rombach-verlag.de/buecher/suchergebnis/rombach/buch/details/texts-animals-environments.html SN - 978-3-7930-9928-4 PB - Rombach Druck- und Verlagshaus CY - Freiburg i. Br. ET - 1. Auflage ER - TY - CHAP A1 - Franke, Werner W. A1 - Zentgraf, Hanswalter A1 - Scheer, Ulrich T1 - Supranucleosomal and non-nucleosomal chromatin configurations N2 - A significant contribution to the understanding of chromatin organization was the d iscovery of the nucleosome as a globular repeating unit of the package of DNA (Hewish and Burgoyne, 1973; Woodcock, 1973; Kornberg, 1974; Olins and Olins, 1974; for review see Oudet et al., 1978 a) . In accord with the original definition and in ag reement with most workers in this field of research we identify a nucleosome as a spheric alor slightly oblate gr anular particle 10-13 nm in diameter, containing about 200 base pairs of DNA and two of each of the four his tones H2a, H2b, H3 and H4. It is this structure in which the bulk of the nuclear chroma tin is organized in most eukaryotic cells, with the exception of the dinofl age llates (Rae and Steele, 1977; dinofl agellate DNA, however, c an be packed into nucleosoma l structures in vitro by addition of the appropriate amounts of histones;the same reference). Although it seems clear from the work reported that condensed and transcriptiona lly inactive chroma tin is contained in nucleosomes as the principle for first order p acking of DNA there are two important questions onto which we are focusing in the present study: ( i ) What is the higher order of p a cking present in - and perhaps typical-of - the condensed sta te of chromatin, and (ii) what is the specific form of arrangement of transcriptionally a ctive chromatin? Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39447 ER - TY - CHAP A1 - Lutz, Werner K. T1 - Structural characteristics of compounds that can be activated to chemically reactive metabolites: use for a prediction of a carcinogenic potential N2 - Many mutagens and carcinogens act via covalent interaction of metabolic intermediates with DNA in the target cell. This report groups those structural elements which are often found to form the basis for a metabolism to such chemically reactive metabolites. ~mpounds which are chemically reactive per se and which do not require metabolic activation form group 1. Group 2 compri~es of olefins and aromatic hydrocarbons where the oxidation via an epoxide can be responsible for the generation of reactive species. Aromatic amines, hydrazines, and nitrosamirres form group 3 requiring an oxidation of a nitrogen atom or of a carbon atom in alpha position to a nitrosated amine. Group 4 compounds are halogenated hydrocarbons which can either give rise to radicals or can form an ·olefin (group 2) upon dehydrohalogenation. Group 5 compounds depend upon some preceding enzymatic activity either not available in the target cell or acting on positions in the molecule which are not directly involved in the subsequent formation of electrophilic atoms. Examples for each group are taken from the "List of Chemieals and Irrdustrial Processes Associated with Cancer in Humans" as compiled by the International Agency for the Research on Cancer, and it is shown that 91% of the organic carcinogens would have been detected on the basis of structural elements characteristic for group 1-5. As opposed to this very high sensitivity, the specificity ( the true negative fraction) of using this approach as a short-term test for carcinogenicity is shown to be bad because detoxification pathways have so far not been taken into account. These competing processes are so complex, however, that either only very extensive knowledge about pharmacokinetics, stability, and reactivity will be required or that in vivo systems have to be used to predict, on a quantitative basis, the darnage expected on the DNA. DNA-binding experiments in vivo are presented with benzene and toluene to demonstrate one possible way for an experimental assessment and it is shown that the detoxification reaction at the methyl group available only in toluene gives rise to a reduction by at least a factor of forty for the binding to rat liver DNA. This quantitative approach available with DNA-binding tests in vivo, also allows evaluation as to whether reactive metabolites and their DNA binding are always the most important single activities contributing to the overall carcinogenicity of a chemical. With the example of the livertumor inducing hexachlorocyclohexane isomers it is shown that situations will be found where reactive metabolites are formed and DNA binding in vivo is measurable but where this activity cannot be the decisive mode of carcinogenic action. It is concluded that the lack of structural elements known to become potentially reactive does not guarantee the lack of a carcinogenic potential. KW - Toxikologie KW - Structureactivity relationship KW - Reactive intermediates KW - Metabolic activation KW - DNA Binding KW - Covalent binding index KW - Carcinogens KW - Benzene Y1 - 1984 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-80105 ER - TY - CHAP A1 - Kurtz, Beth A1 - Schneider, Wolfgang A1 - Borkowski, John G. A1 - Carr, Martha A1 - Turner, Lisa A. T1 - Sources of memory and metamemory development: Societal, parental, and educational influences N2 - This project had two goals: (1) to examine the impact of strategy training on memory performance in German and American children, and (2) to search for environmental correlates of individual differences in cognitive processes. Following pretesting, 437 children were divided into training and control groups, with the former receiving training in clustering strategies. Trained children showed sizable strategy maintenance and transfer effects two weeks and six months later. Parents and teachers completed questionnaires about the teaching of strategies and their attributional beliefs about children's academic successes and failures. The differences in strategie behavior and attributions of German and American children were due, in part, to differences in strategy-enriched environments. KW - Psychologie Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50524 ER - TY - CHAP A1 - Zillober, Christian T1 - Sequential convex programming in theory and praxis N2 - In this paper, convex approximation methods, suclt as CONLIN, the method of moving asymptotes (MMA) and a stabilized version of MMA (Sequential Convex Programming), are discussed with respect to their convergence behaviour. In an extensive numerical study they are :finally compared with other well-known optimization methods at 72 examples of sizing problems. Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-35513 ER - TY - CHAP A1 - Sagelsdorff, P. A1 - Lutz, Werner K. T1 - Sensitivity of DNA and nucleotides to oxidation by permanganate and hydrogen peroxide N2 - no abstract available KW - Toxikologie Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-80062 ER - TY - CHAP A1 - Bossert, Sabine A1 - Meiler, Caroline A1 - Laessle, Reinhold A1 - Ellgring, Heiner A1 - Pirke, Karl-Martin T1 - Responses to visual perception of food in eating disorders N2 - No abstract available KW - Psychologie Y1 - 1989 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58762 ER - TY - CHAP ED - Brill, Michael ED - Jonsson, Gudberg ED - Schwab, Frank T1 - Research Network on Methodology for the Analysis of Social Interaction. Proceedings of the ninth meeting of MASI. T1 - Forschungsnetzwerk zur Methodik der Analyse sozialer Interaktionen. Berichte des neunten Meetings von MASI. N2 - T-pattern analysis supports studies of various aspects of human or animal behavior as well as interaction between human subjects and animal or artificial agents. The following proceedings give an overiew on the application of T-pattern analysis in different research fields like media, gaming, human behaviour, social and organisational interaction as well as sports and health. KW - Verhaltensmuster KW - T-Pattern KW - Theme KW - human behaviour KW - social interaction KW - detection KW - Verhaltensanalyse KW - Interaktion KW - Nonverbal KW - MASI KW - Untersuchungsinstrument KW - Muster KW - Bewegung KW - Gestik Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-147135 SN - 978-3-945459-16-4 ER - TY - CHAP A1 - Mori, Kazuyasu A1 - Rethwilm, Axel A1 - Schwinn, Andreas A1 - Horak, Ivan T1 - Replication of human immunodeficiency virus type 1 in human t-cells expressing antisense RNA N2 - No abstract available. KW - HIV Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86426 ER - TY - CHAP A1 - Scheer, Ulrich A1 - Trendelenburg, M. F. A1 - Franke, Werner W. T1 - Regulation of transcription of ribosomal RNA genes during amphibian oogenesis N2 - No abstract available Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33700 ER - TY - CHAP A1 - Lutz, Werner K. T1 - Quantitative evaluation of DNA-binding data in vivo for low-dose extrapolations N2 - no abstract available KW - Toxikologie Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-80079 ER - TY - CHAP A1 - Hedke, K. A1 - Eckstein, V. A1 - May, G. A1 - Kaden, J. A1 - Müller-Ruchholtz, W. A1 - Ulrichs, Karin T1 - Production of Xenophile Antibodies (XA) in Type I Diabetic Patients is Strongly Influenced by Diabetes and/or Dialysis N2 - No abstract available Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45642 ER - TY - CHAP ED - von Mammen, Sebastian ED - Klemke, Roland ED - Lorber, Martin T1 - Proceedings of the 1st Games Technology Summit BT - part of Clash of Realites 11th International Conference on the Technology and Theory of Digital Games N2 - As part of the Clash of Realities International Conference on the Technology and Theory of Digital Games, the Game Technology Summit is a premium venue to bring together experts from academia and industry to disseminate state-of-the-art research on trending technology topics in digital games. In this first iteration of the Game Technology Summit, we specifically paid attention on how the successes in AI in Natural User Interfaces have been impacting the games industry (industry track) and which scientific, state-of-the-art ideas and approaches are currently pursued (scientific track). KW - Veranstaltung KW - Künstliche Intelligenz KW - Mensch-Maschine-Kommunikation KW - Computerspiel KW - natural user interfaces KW - artificial intelligence Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-245776 SN - 978-3-945459-36-2 ER - TY - CHAP A1 - Schneider, Wolfgang T1 - Problems of longitudinal studies with young children: Practical, conceptual, and methodological issues N2 - No abstract available. KW - Längsschnittuntersuchung KW - Kind Y1 - 1989 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86521 ER - TY - CHAP A1 - Werner, Rudolf A1 - Higuchi, Takahiro A1 - Muegge, Dirk A1 - Javadi, Mehrbod S. A1 - Märkl, Bruno A1 - Aulmann, Christoph A1 - Buck, Andreas K. A1 - Fassnacht, Martin A1 - Lapa, Constantin A1 - Kreissl, Michael C. T1 - Predictive value of FDG-PET in patients with advanced medullary thyroid cancer undergoing vandetanib treatment T2 - Journal of Nuclear Medicine N2 - Introduction: The prognosis of medullary thyroid carcinoma (MTC) is poor using common chemotherapeutic approaches. However, during the last years encouraging results of recently introduced tyrosine kinase inhibitors (TKI) such as vandetanib have been published. In this study we aimed to correlate the results of \(^{18}\)F-fluorodeoxyglucose ([\(^{18}\)F]FDG) positron emission tomography (PET) imaging with treatment outcome. Methods: Eighteen patients after thyroidectomy with recurrent/advanced MTC lesions receiving vandetanib (300 mg orally/day) could be analysed. A baseline \(^{18}\)F-FDG PET prior to and a follow-up \(^{18}\)F-FDG PET 3 months after TKI initiation were performed. During follow-up, tumor progression was assessed every 3 months including computed tomography according to RECIST. Progression-free survival (PFS) was correlated with the maximum standardized uptake value of \(^{18}\)F-FDG in lymph nodes (SUV(LN)max) or visceral metastases (SUV(MTS)max) as well as with clinical parameters using ROC analysis. Results: Within median 3.6 years of follow-up, 9 patients showed disease progression at median 8.5 months after TKI initiation. An elevated glucose consumption assessed by baseline \(^{18}\)F-FDG PET (SUV(LN)max > 7.25) could predict a shorter PFS (2 y) with an accuracy of 76.5% (SUV(LN)max <7.25, 4.3 y; p=0.03). Accordingly, preserved tumor metabolism in the follow-up PET (SUV(MTS)max >2.7) also demonstrated an unfavorable prognosis (accuracy, 85.7%). On the other hand, none of the clinical parameters reached significance in response prediction. Conclusions: In patients with advanced and progressive MTC, tumors with higher metabolic activity at baseline are more aggressive and more prone to progression as reflected by a shorter PFS; they should be monitored more closely. Preserved glucose consumption 3 months after treatment initiation was also related to poorer prognosis. KW - 18F-FDG KW - vandetanib KW - TKI KW - PET KW - positron emission tomography Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161147 UR - http://jnm.snmjournals.org/content/58/supplement_1/169 SN - 0161-5505 N1 - This research was originally published in JNM. Rudolf A. Werner, Takahiro Higuchi, Dirk O. Muegge, Mehrbod S. Javadi, B. Märkl, C. Aulmann, Andreas K. Buck, Martin Fassnacht, Constantin Lapa, Michael C. Kreissl. Predictive value of FDG-PET in patients with advanced medullary thyroid cancer undergoing vandetanib treatment. J Nucl Med. May 1, 2017; vol. 58 no. supplement 1:169. © SNMMI. VL - 58 IS - no. supplement 1 ER - TY - CHAP A1 - Vollmer, H. C. A1 - Ellgring, Johann Heinrich A1 - Ferstl, R. T1 - Prediction of premature termination of therapy in the treatment of drug addicts N2 - No abstract available KW - Psychologie Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50274 ER - TY - CHAP A1 - Schüssler, Ulrich A1 - Okrusch, Martin A1 - Seidel, Eberhard A1 - Kreuzer, Hans A1 - Raschka, Helmut T1 - Pre- to early Variscan magmatism in the Bohemian Massif N2 - No abstract available Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39171 ER - TY - CHAP A1 - Peter, R. U. A1 - Schartl, Manfred A1 - Anders, F. A1 - Duncker, H.-R. T1 - Pigment pattern formation during embryogenesis in Xiphophorus N2 - No abstract available. KW - Schwertkärpfling KW - Embryonalentwicklung KW - Pigmentmuster Y1 - 1985 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-69370 ER - TY - CHAP A1 - Schartl, A. A1 - Schartl, Manfred A1 - Anders, F. T1 - Phenotypic conversion of malignant melanoma to benign melanoma and vice versa in Xiphophorus N2 - No abstract available. KW - Schwertkärpfling KW - Krebs Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86662 ER - TY - CHAP A1 - Werner, Rudolf A1 - Wakabayashi, Hiroshi A1 - Jahns, Roland A1 - Ergün, Süleyman A1 - Jahns, Valerie A1 - Higuchi, Takahiro T1 - PET-Guided Histological Characterization of Myocardial Infiltrating Cells in a Rat Model of Myocarditis T2 - European Heart Journal - Cardiovascular Imaging N2 - No abstract available. KW - Myokarditis KW - positron emission tomography KW - myocarditis KW - PET KW - 18F-FDG Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161127 SN - 2047-2404 N1 - This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal Cardiovascular Imaging following peer review. The version of record . Eur Heart J Cardiovasc Imaging. ISSN: 2047-2404. Supplement, vol. 18, i1-i3, May 2017 is available online at: 10.1093/ehjci/jex071. VL - 18 IS - Supplement PB - Oxford University Press ER - TY - CHAP A1 - Franke, Werner W. A1 - Scheer, Ulrich T1 - Pathways of nucleocytoplasmic translocation of ribonucleoproteins N2 - No abstract available Y1 - 1974 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33832 ER - TY - CHAP A1 - Epplée, Rafael A1 - Langbehn, Eike T1 - Overlapping Architecture: Implementation of Impossible Spaces in Virtual Reality Games N2 - Natural walking in virtual reality games is constrained by the physical boundaries defined by the size of the player’s tracking space. Impossible spaces, a redirected walking technique, enlarge the virtual environment by creating overlapping architecture and letting multiple locations occupy the same physical space. Within certain thresholds, this is subtle to the player. In this paper, we present our approach to implement such impossible spaces and describe how we handled challenges like objects with simulated physics or precomputed global illumination. KW - virtual reality KW - games KW - locomotion Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-246045 ER - TY - CHAP A1 - Marohn, Frank T1 - On testing the exponential and Gumbel distribution N2 - No abstract available KW - Gumbel-Verteilung KW - Extremal–I–Verteilung KW - generalized Pareto distribution KW - extreme value distribution Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45804 ER - TY - CHAP A1 - Dabauvalle, M.-C. A1 - Wilken, N. A1 - Ewald, A. A1 - Kuhbier, A. A1 - Senécal, J.-L. A1 - Scheer, Ulrich T1 - Nuclear pore complex structure analyzed by immunogold EM with human autoantibodies N2 - No abstract available Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39439 ER - TY - CHAP A1 - Hodgson, Barbara A1 - Reusch, Wolfgang A1 - Kjöllerström, Bengt A1 - Velarde, Manuel T1 - Non-Formal Education N2 - No abstract available Y1 - 1989 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30620 ER - TY - CHAP A1 - Winoto-Morbach, S. A1 - Ulrichs, Karin A1 - Müller-Ruchholtz, W. T1 - New Developments in Biodegradable Microspheres For Magnetic Separation Techniques N2 - No abstract available KW - Immunbiologie Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45712 ER - TY - CHAP A1 - Franke, Werner W. A1 - Scheer, Ulrich A1 - Trendelenburg, Michael F. A1 - Zentgraf, H. A1 - Spring, H. T1 - Morphology of transcriptionally active chromatin N2 - Some decades ago it was noted by cytologists that within the interphase nucleus large portions of the transcriptionally ("genetically," in their terms) inactive chromosomal material are contained in aggregates of condensed chromatin, the "chromocenters," whereas transcriptionally active regions of chromosomes appear in a more dispersed form and are less intensely stained with DNA-directed staining procedures (Heitz 1929, 1932, 1956; Bauer 1933). The hypothesis that condensed chromatin is usually characterized by very low or no transcriptional activity, and that transcription occurs in loosely packed forms of chromatin (including, in most cells, the nucleolar chromatin) has received support from studies of ultrathin sections in the electron microscope and from the numerous attempts to separate transcriptionally active from inactive chromatin biochemically (for references, see Anderson et al. 1975; Berkowitz and Doty 1975; Krieg and Wells 1976; Rickwood and Birnie 1976; Gottesfeld 1977). Electron microscopic autoradiography has revealed that sites of RNA synthesis are enriched in dispersed chromatin regions located at the margins of condensed chromatin (Fakan and Bernhard 1971, 1973; Bouteille et al. 1974; Bachellerie et al. 1975) and are characterized by the occurrence of distinct granular and fibrillar ribonucleoprotein (RNP) structures, such as perichromatin granules and fibrils. The discovery that, in most eukaryotic nuclei, major parts of the chromatin are organized in the form of nucleosomes (Olins and Olins 1974; Kornberg 1974; Baldwin et al. 1975) has raised the question whether the same nucleosomal packing of DNA is also present in transcriptionally active chromatin strands. Recent detailed examination of the morphology of active and inactive chromatin involving a diversity of electron microscopic methods, particularly the spreading technique by Miller and coworkers (Miller and Beatty 1969; Miller and Bakken 1972), has indicated that the DNA of some actively transcribed regions is not packed into nucleosomal particles but is present in a rather extended form within a relatively thin (4-7 nm) chromatin fiber. Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41097 ER - TY - CHAP A1 - Trendelenburg, Michael F. A1 - Spring, Herbert A1 - Scheer, Ulrich A1 - Franke, Werner W. T1 - Morphology of nucleolar cistrons in a plant cell, Acetabularia mediterranea N2 - The structural organization of transcriptionally active DNA that contains cistrons for precursor molecules of ribosomal RNA is described in positively stained spread preparations from nuclei and nucleoli isolated from the green alga, Acetabularia mediterranea Lmx. These nuclei contain large aggregates of nucleolar subunits in which fibril-covered regions, the putative active cistrons for precursors of ribosomal RNA, alternate with fibril-free intercepts, the "spacers". The length distribution of the different intercepts of this DNA is given, and the pattern is compared with those shown in animal cell systems. The data are discussed in relation to problems of transcription and of amplification of ribosomal RNA genes. KW - ribosomal RNA genes; electron microscopy; spread preparations Y1 - 1974 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-32213 ER - TY - CHAP A1 - Schartl, Manfred A1 - Mäueler, Winfried A1 - Raulf, Friedrich A1 - Robertson, Scott M. T1 - Molecular aspects of melanoma formation in Xiphophorus N2 - No abstract available. KW - Schwertkärpfling KW - Krebs Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-72689 ER - TY - CHAP A1 - Schreibman, Martin P. A1 - Schartl, Manfred A1 - Kallman, Klaus D. A1 - Magliulo-Cepriano, Lucia T1 - Molecular approaches to study the genetic regulation of the fish reproductive system N2 - No abstract available. KW - Fische Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86679 ER - TY - CHAP A1 - Viviani, A. A1 - Lutz, Werner K. T1 - Modulation of the in vivo covalent binding of the carcinogen benzo(a)pyrene to rat liver DNA by selective induction of microsomal and nuclear aryl hydrocarbon hydroxylase activity N2 - The influence of microsomal (mAHH) and nuclear (nAHH) aryl hydrocarbon hydroxylase activity on the covalent binding of t:titiated benzo(a)pyrene to rat liver DNA was evaluated in vivo. Induction ofmAHH was obtained after phenobarbitone treatment (180% of control), which increased DNA binding to 210%, but left the nAHH unchanged. mAHH and nAHH were slightly indilced with dieldrin (130% and 120%), but the binding remairred unchanged. The increasing effect of mAHlt as weil as the possibly decreasing effect of nAHH induction on the binding became obvious when the data of 11 individual rats were used to solve the equation Binding = aX(mAHH) + bX(nAHH) + c. Multiple linear regression analysis resulted in positive values for a and c, a negative value for b, and a multiple correlation coefficient R = 0.82. An influence of other enzymes involved in the metabolism of benzo(a)pyrene cannot be excluded. The Study shows clearly that the binding of a foreign compound to DNA in vivo is not only dependent on microsomal enzyme activities but also on nuclear activities even if the latter are considerably lower than those of mic'rosomes. KW - DNA KW - Benzo(a)pyrene KW - DNA-Binding KW - Carcinogen KW - Enzyme KW - Induction KW - Aryl Hydrocarbon Hydroxylase KW - Rats KW - Phenobarbitone KW - Dieldrin Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-80132 ER -