TY  - JOUR
A1  - Michalski, Kerstin
A1  - Schlötelburg, Wiebke
A1  - Hartrampf, Philipp E.
A1  - Kosmala, Aleksander
A1  - Buck, Andreas K.
A1  - Hahner, Stefanie
A1  - Schirbel, Andreas
T1  - Radiopharmaceuticals for treatment of adrenocortical carcinoma
JF  - Pharmaceuticals
N2  - Adrenocortical carcinoma (ACC) represents a rare tumor entity with limited treatment options and usually rapid tumor progression in case of metastatic disease. As further treatment options are needed and ACC metastases are sensitive to external beam radiation, novel theranostic approaches could complement established therapeutic concepts. Recent developments focus on targeting adrenal cortex-specific enzymes like the theranostic twin [\(^{123/131}\)I]IMAZA that shows a good image quality and a promising therapeutic effect in selected patients. But other established molecular targets in nuclear medicine such as the C-X-C motif chemokine receptor 4 (CXCR4) could possibly enhance the therapeutic regimen as well in a subgroup of patients. The aims of this review are to give an overview of innovative radiopharmaceuticals for the treatment of ACC and to present the different molecular targets, as well as to show future perspectives for further developments since a radiopharmaceutical with a broad application range is still warranted.
KW  - adrenocortical carcinoma
KW  - theranostics
KW  - endoradiotherapy
KW  - IMAZA
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-355901
SN  - 1424-8247
VL  - 17
IS  - 1
ER  -