TY  - JOUR
A1  - Feuerstein, G.
A1  - Sirén, Anna-Leena
T1  - Opioid peptides: A role in hypertension? [Brief Review]
N2  - This review is an attempt to highlight evidence that may implicate the endogenaus opioid system in the pathogenesis of hypertension in humans. The evidence raised includes biochemical, physiological, pharmacological, and behavioral studies con~ucted in in vitro andin vivo systems, experimental models of hypertension, and hornans with essential hypertension. While the compelling biochemical and pharmacological evidence in experimental animals clearly shows the presence of opioid peptides and their receptors in strategic sites of cardiovascular control and potent cardiovascular response to opioid peptides, opioid antagonists show no consistent blockade or reversal of hypertension in experimental animals or humans. One possible explanation for this phenomenon could be the vast redundancy in systems regulating blood pressure (i.e., the blockade ofone system stillleaves many other systerils fully able to rapidly offset the eliminated system). Regarding the opioid system, the situation is much more complex, since some opioid receptors (\(\mu\)-type) niediate pressor responses, while other receptors (\(\kappa\)type) mediate depressor responses. Therefore, nonselective opioid receptor antagonists (e.g., naloxone), which block both types ofreceptors, can be devoid ofany cardiovascular activity, while a selective \(\mu\)-receptor antagonist or a selective arid potent \(\kappa\)-receptor agonist may produce the desired antihypertensive elfect. A combination of both actions (i.e., a drug that is both \(\mu\)antagonist and a \(\kappa\)antagonist) might be even more advantageous. Until such compounds are developed, this hypothesis will be hard to prove.
KW  - Neurobiologie
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63262
ER  - 
TY  - JOUR
A1  - Reimer, Georg
A1  - Raska, Ivan
A1  - Tan, Eng M.
A1  - Scheer, Ulrich
T1  - Human autoantibodies: probes for nucleolus structure and function
N2  - No abstract available
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41410
ER  - 
TY  - JOUR
A1  - Harth-Peter, Waltraud
T1  - Maria Montessori: Texte und Gegenwartsdiskussion / Winfried Böhm (Hrsg.)
N2  - Rezension zu Winfried Böhm (Hrsg.): Maria Montessori. Texte und Gegenwartsdiskussion. 3., neu bearbeitete Auflage. Bad Heilbrunn 1985
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42817
ER  - 
TY  - JOUR
A1  - König, Dorothea
T1  - Kleines Wörterbuch der kirchenslavischen Sprache / Jean Paul Deschler
N2  - Kleines Wörterbuch der kirchenslavischen Sprache, München, 1987 / Jean Paul Deschler
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38615
ER  - 
TY  - JOUR
A1  - König, Dorothea
T1  - The Cakavian dialect of Orlec on the island of Cres, Amsterdam, 1985 / H. P. Houtzagers
N2  - The Cakavian dialect of Orlec on the island of Cres, Amsterdam: Rodopi, 1985, 415 S. / H. P. Houtzagers
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38738
ER  -