TY  - JOUR
A1  - Poppe, Lidia Marilia
A1  - Anders, Diana
A1  - Kneitz, Hermann
A1  - Bröcker, Eva-Bettina
A1  - Benoit, Sandrine
T1  - Flagellate dermatitis caused by shiitake mushrooms
T1  - Dermatite flagelada após a ingestão de fungos shiitake
JF  - Anais Brasileiros de Dermatologia
N2  - Shiitake (Lentinus edodes) is the second most consumed mushroom in the world. It has long been known in Asian medicine for its anticarcinogenic, antihypertensive and serum cholesterol level reduction properties. Nevertheless, the consumption of raw or not well-cooked mushrooms may cause skin eruptions which usually occur 24 to 48 hours after ingestion and are characterized by linearly arranged pruritic erythematous papules and plaques. We present a 36-year-old patient that developed typical symptoms 24 hours after consumption of shiitake mushrooms and summarize therapeutic options and particularities of this disease.
N2  - Shiitake (Lentinus edodes) é o segundo tipo de cogumelo mais consumido no mundo. Suas propriedades terapêuticas antitumorais, anti-hipertensivas e redutoras dos níveis elevados de colesterol são há muito conhecidas pela população asiática. Após ingestão desse cogumelo, cru ou malcozido, podem desenvolver-se lesões eritematosas lineares, pruriginosas, que surgem após 24 ou 48 horas em todo o corpo. Apresentamos um paciente de 36 anos com anamnese e clínica típicos, e comentamos as alternativas terapêuticas e nuances dessa dermatose.
KW  - bleomicina
KW  - shiitake-dermatite
KW  - bleomycin
KW  - flagellate dermatitis
KW  - shiitake dermatitis
KW  - shiitake mushrooms
KW  - dermatite flagelada
KW  - fungos shiitake
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-134362
VL  - 87
IS  - 3
ER  - 
TY  - JOUR
A1  - Anders, Diana
A1  - Trautmann, Axel
T1  - Allergic anaphylaxis due to subcutaneously injected heparin
JF  - Allergy, Asthma & Clinical Immunology
N2  - Heparins are one of the most used class of anticoagulants in daily clinical practice. Despite their widespread application immune-mediated hypersensitivity reactions to heparins are rare. Among these, the delayed-type reactions to s.c. injected heparins are well-known usually presenting as circumscribed eczematous plaques at the injection sites. In contrast, potentially life-threatening systemic immediate-type anaphylactic reactions to heparins are extremely rare. Recently, some cases of non-allergic anaphylaxis could be attributed to undesirable heparin contaminants.

A 43-year-old patient developed severe anaphylaxis symptoms within 5–10 minutes after s.c. injection of enoxaparin. Titrated skin prick testing with wheal and flare responses up to an enoxaparin dilution of 1:10.000 indicated a probable allergic mechanism of the enoxaparin-induced anaphylaxis. The basophil activation test as an additional in-vitro test method was negative. Furthermore, skin prick testing showed rather broad cross-reactivity among different heparin preparations tested.

In the presented case, history, symptoms, and results of skin testing strongly suggested an IgE-mediated allergic hypersensitivity against different heparins. Therefore, as safe alternative anticoagulants the patient could receive beneath coumarins the hirudins or direct thrombin inhibitors. Because these compounds have a completely different molecular structure compared with the heparin-polysaccharides.
KW  - Anaphylaxis
KW  - Allergy
KW  - Basophil activation test
KW  - Enoxaparin
KW  - Heparin
KW  - Hypersensitivity
KW  - Immunoglobulin E
KW  - Immediate-type
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-96214
UR  - http://www.aacijournal.com/content/9/1/1
ER  -