TY  - JOUR
A1  - Tacke, Reinhold
A1  - Lange, Hartwig
A1  - Bentlage, Anke
A1  - Sheldrick, William S.
A1  - Ernst, Ludger
T1  - 2.2.5.5-Tetraorganyl-1.4-dioxa-2.5-disilacyclohexane/2,2,5,5-Tetraorganyl-1,4-dioxa-2,5-disilacyclohexanes
JF  - Zeitschrift für Naturforschung B
N2  - The 2,2,5,5-tetraorganyl-1,4-dioxa-2,5-disilacyclohexanes 2a-2c were prepared by condensation of the corresponding (hydroxymethyl)diorganylsilanes 1 a-1 c. The constitution of the heterocycles was confirmed by elemental analyses, cryoscopic measurements, mass spectrometry, and NMR-spectroscopic \((^1H, ^{13}C)\) investigations. The molecular structure of 2 b was determined by X-ray diffraction analysis.
KW  - 1,4-Dioxa-2
KW  - 5-disila-cyclohexane ring system
KW  - synthesis
KW  - structure
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128423
VL  - 38
IS  - 2
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Lange, Hartwig
A1  - Sheldrick, William S.
A1  - Lambrecht, Günter
A1  - Moser, Ulrich
A1  - Mutschler, Ernst
T1  - Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon
T1  - Sila-Pharmaca, 31 th Communication [1] Synthesis, Structure, and Pharmacological Properties of Diphenyl(2-piperidinoethoxymethyl)silanol and its Carbon Analogue
JF  - Zeitschrift für Naturforschung B
N2  - In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).
KW  - antimuscarinic and papaverine-like activity
KW  - sila-substitution
KW  - crystal and molecular structure
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128410
VL  - 38
IS  - 6
ER  -