TY  - JOUR
A1  - Mueller-Loebnitz, Christoph
A1  - Ostermann, Helmut
A1  - Franzke, Anke
A1  - Loeffler, Juergen
A1  - Uharek, Lutz
A1  - Topp, Max
A1  - Einsele, Hermann
T1  - Immunological Aspects of Candida and Aspergillus Systemic Fungal Infections
JF  - Interdisciplinary Perspectives on Infectious Diseases
N2  - Patients with allogeneic stem cell transplantation (SCT) have a high risk of invasive fungal infections (IFIs) even after neutrophil regeneration. Immunological aspects might play a very important role in the IFI development in these patients. Some data are available supporting the identification of high-risk patients with IFI for example patients receiving stem cells fromTLR4 haplotype S4 positive donors. Key defense mechanisms against IFI include the activation of neutrophils, the phagocytosis of germinating conidia by dendritic cells, and the fight of the cells of the innate immunity such as monocytes and natural killer cells against germlings and hyphae. Furthermore, immunosuppressive drugs interact with immune effector cells influencing the specific fungal immune defense and antimycotic drugs might interact with immune response. Based on the current knowledge on immunological mechanism in Aspergillus fumigatus, the first approaches of an immunotherapy using human T cells are in development. This might be an option for the future of aspergillosis patients having a poor prognosis with conventional treatment.
KW  - Infectious Diseases
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-129327
IS  - ID 102934
ER  -