TY  - JOUR
A1  - Brehony, Carina
A1  - Trotter, Caronline L.
A1  - Ramsay, Mary E.
A1  - Chandra, Manosree
A1  - Jolley, Keith A.
A1  - van der Ende, Arie
A1  - Carion, Françoise
A1  - Berthelsen, Lene
A1  - Hoffmann, Steen
A1  - Harðardóttir, Hjördís
A1  - Vazques, Julio A.
A1  - Murphy, Karen
A1  - Toropainen, Maija
A1  - Caniça, Manuela
A1  - Ferreira, Eugenia
A1  - Diggle, Mathew
A1  - Edwards, Giles F.
A1  - Taha, Muhamed-Kheir
A1  - Stefanelli, Paola
A1  - Kriz, Paula
A1  - Gray, Steve J.
A1  - Fox, Andrew J.
A1  - Jacobsson, Susanne
A1  - Claus, Heike
A1  - Vogel, Ulrich
A1  - Tzanakaki, Georgina
A1  - Heuberger, Sigrid
A1  - Caugant, Dominique A.
A1  - Frosch, Matthias
A1  - Maiden, Martin C. J.
T1  - Implications of Differential Age Distribution of Disease-Associated Meningococcal Lineages for Vaccine Development
JF  - Clinical and Vaccine Immunology : CVI
N2  - New vaccines targeting meningococci expressing serogroup B polysaccharide have been developed, with some being licensed in Europe. Coverage depends on the distribution of disease-associated genotypes, which may vary by age. It is well established that a small number of hyperinvasive lineages account for most disease, and these lineages are associated with particular antigens, including vaccine candidates. A collection of 4,048 representative meningococcal disease isolates from 18 European countries, collected over a 3-year period, were characterized by multilocus sequence typing (MLST). Age data were available for 3,147 isolates. The proportions of hyperinvasive lineages, identified as particular clonal complexes (ccs) by MLST, differed among age groups. Subjects <1 year of age experienced lower risk of sequence type 11 (ST-11) cc, ST-32 cc, and ST-269 cc disease and higher risk of disease due to unassigned STs, 1- to 4-year-olds experienced lower risk of ST-11 cc and ST-32 cc disease, 5- to 14-year-olds were less likely to experience ST-11 cc and ST-269 cc disease, and ≥25-year-olds were more likely to experience disease due to less common ccs and unassigned STs. Younger and older subjects were vulnerable to a more diverse set of genotypes, indicating the more clonal nature of genotypes affecting adolescents and young adults. Knowledge of temporal and spatial diversity and the dynamics of meningococcal populations is essential for disease control by vaccines, as coverage is lineage specific. The nonrandom age distribution of hyperinvasive lineages has consequences for the design and implementation of vaccines, as different variants, or perhaps targets, may be required for different age groups.
KW  - differential age distribution
KW  - disease-associated
KW  - meningococcal lineages
KW  - vaccine development
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-120808
VL  - 21
IS  - 6
ER  - 
TY  - JOUR
A1  - Elias, Johannes
A1  - Schouls, Leo M.
A1  - van de Pol, Ingrid
A1  - Keijzers, Wendy C.
A1  - Martin, Diana R.
A1  - Glennie, Anne
A1  - Oster, Philipp
A1  - Frosch, Matthias
A1  - Vogel, Ulrich
A1  - van der Ende, Arie
T1  - Vaccine Preventability of Meningococcal Clone, Greater Aachen Region, Germany
N2  - No abstract available
KW  - IMD
Y1  - 2010
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-68083
ER  -