TY  - JOUR
A1  - Elkon, Ran
A1  - Loayza-Puch, Fabricio
A1  - Korkmaz, Gozde
A1  - Lopes, Rui
A1  - van Breugel, Pieter C
A1  - Bleijerveld, Onno B
A1  - Altelaar, AF Maarten
A1  - Wolf, Elmar
A1  - Lorenzin, Francesca
A1  - Eilers, Martin
A1  - Agami, Reuven
T1  - Myc coordinates transcription and translation to enhance transformation and suppress invasiveness
JF  - EMBO reports
N2  - c‐Myc is one of the major human proto‐oncogenes and is often associated with tumor aggression and poor clinical outcome. Paradoxically, Myc was also reported as a suppressor of cell motility, invasiveness, and metastasis. Among the direct targets of Myc are many components of the protein synthesis machinery whose induction results in an overall increase in protein synthesis that empowers tumor cell growth. At present, it is largely unknown whether beyond the global enhancement of protein synthesis, Myc activation results in translation modulation of specific genes. Here, we measured Myc‐induced global changes in gene expression at the transcription, translation, and protein levels and uncovered extensive transcript‐specific regulation of protein translation. Particularly, we detected a broad coordination between regulation of transcription and translation upon modulation of Myc activity and showed the connection of these responses to mTOR signaling to enhance oncogenic transformation and to the TGFβ pathway to modulate cell migration and invasiveness. Our results elucidate novel facets of Myc‐induced cellular responses and provide a more comprehensive view of the consequences of its activation in cancer cells.
KW  - c‐Myc
KW  - transcriptional responses
KW  - translational regulation
KW  - transcription
KW  - transformation
KW  - metastasis
KW  - cancer
KW  - protein biosynthesis & quality control
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150373
VL  - 16
IS  - 12
ER  -