TY  - JOUR
A1  - Azzami, Klara
A1  - Ritter, Wolfgang
A1  - Tautz, Jürgen
A1  - Beier, Hildburg
T1  - Infection of honey bees with acute bee paralysis virus does not trigger humoral or cellular immune responses
JF  - Archives of Virology
N2  - We have studied the responses of honey bees at different life stages (Apis mellifera) to controlled infection with acute bee paralysis virus and have identified the haemolymph of infected larvae and adult worker bees as the compartment where massive propagation of ABPV occurs. Insects respond with a broad spectrum of induced innate immune reactions to bacterial infections, whereas defence mechanisms based on RNA interference play a major role in antiviral immunity. In this study, we have determined that honey bee larvae and adult workers do not produce a humoral immune reaction upon artificial infection with ABPV, in contrast to control individuals challenged with Escherichia coli. ABPV-infected bees produced neither elevated levels of specific antimicrobial peptides (AMPs), such as hymenoptaecin and defensin, nor any general antimicrobial activity, as revealed by inhibition-zone assays. Additionally, adult bees did not generate melanised nodules upon ABPV infection, an important cellular immune function activated by bacteria and viruses in some insects. Challenge of bees with both ABPV and E. coli showed that innate humoral and cellular immune reactions are induced in mixed infections, albeit at a reduced level.
KW  - chemosensory protein
KW  - bee larva
KW  - adult bee
KW  - honey bee
KW  - larva
KW  - work bee
KW  - infected bee
KW  - immune response
KW  - young work bee
KW  - capsid protein
KW  - abdominal
KW  - tergite
KW  - haemolymph
KW  - sample
KW  - Imd pathway
KW  - worker bee larva
KW  - antimicrobial
KW  - peptide
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-126863
VL  - 157
IS  - 4
ER  -