TY  - JOUR
A1  - Coelho, Luis Pedro
A1  - Kultima, Jens Roat
A1  - Costea, Paul Igor
A1  - Fournier, Coralie
A1  - Pan, Yuanlong
A1  - Czarnecki-Maulden, Gail
A1  - Hayward, Matthew Robert
A1  - Forslund, Sofia K.
A1  - Schmidt, Thomas Sebastian Benedikt
A1  - Descombes, Patrick
A1  - Jackson, Janet R.
A1  - Li, Qinghong
A1  - Bork, Peer
T1  - Similarity of the dog and human gut microbiomes in gene content and response to diet
JF  - Microbiome
N2  - Background
Gut microbes influence their hosts in many ways, in particular by modulating the impact of diet. These effects have been studied most extensively in humans and mice. In this work, we used whole genome metagenomics to investigate the relationship between the gut metagenomes of dogs, humans, mice, and pigs.

Results
We present a dog gut microbiome gene catalog containing 1,247,405 genes (based on 129 metagenomes and a total of 1.9 terabasepairs of sequencing data). Based on this catalog and taxonomic abundance profiling, we show that the dog microbiome is closer to the human microbiome than the microbiome of either pigs or mice. To investigate this similarity in terms of response to dietary changes, we report on a randomized intervention with two diets (high-protein/low-carbohydrate vs. lower protein/higher carbohydrate). We show that diet has a large and reproducible effect on the dog microbiome, independent of breed or sex. Moreover, the responses were in agreement with those observed in previous human studies.

Conclusions
We conclude that findings in dogs may be predictive of human microbiome results. In particular, a novel finding is that overweight or obese dogs experience larger compositional shifts than lean dogs in response to a high-protein diet.
KW  - microbiome
KW  - diet
KW  - metagenomics
KW  - dog microbiome
KW  - human microbiome
KW  - mouse microbiome
KW  - pig microbiome
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-223177
VL  - 6
ER  -