TY  - JOUR
A1  - Sendtner, Michael
A1  - Dittrich, F.
A1  - Hughes, R. A.
A1  - Thoenen, H.
T1  - Actions of CNTF and neurotrophins on degenerating motoneurons : preclinical studies and clinical implications
N2  - Spinal motoneurons innervating skeletal muscle were amongst the first neurons shown to require the presence of their target cells to develop appropriately. Isolated embryonie chick and rat motoneurons have been used to identify neurotrophic factors and cytokines capable of supporting the survival of developing motoneurons. Such factors include ciliary neurotrophic factor (CNTF), which is present physiologically in high amounts in myelinating Schwann cells of peripheral nerves, and brain-derived neurotrophic factor (BDNF) which is synthesized in skeletal muscle and, after peripheral nerve lesion. in Schwann cells. These factors have been further analyzed for their physiological significance in maintaining motoneuron function in vivo, and for their potential therapeutic usefulness in degenerative motoneuron disease. Both CNTF and BDNF are capable of rescuing injured facial motoneurons in newbom rats. Furthermore, CNTF prolongs survival and improves motor function of pmn mice, an animal model for degenerative motoneuron disease, by preventing degeneration of motoneuron axons and somata. Thus treatment of human motoneuron disease with neurotrophic factors should be possible, provided that rational means for application of these factors can be established considering also the appearance of potential side effects.
KW  - Neurobiologie
KW  - Motor neuron disease; Ciliary neurotrophic factor; Brain-derived neurotrophic factor; Animal models; Neurotrophic factors
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62939
ER  - 
TY  - RPRT
A1  - Lütticken, Claudia
A1  - Wegenka, Ursula M.
A1  - Yuan, Juping
A1  - Buschmann, Jan
A1  - Schindler, Chris
A1  - Ziemiecki, Andrew
A1  - Harpur, Alisa G.
A1  - Wilks, Andrew F.
A1  - Yasukawa, Kiyoshi
A1  - Taga, Tetsuya
A1  - Kishimoto, Tadamitsu
A1  - Barbieri, Giovanna
A1  - Sendtner, Michael
A1  - Pellegrini, Sandra
A1  - Heinrich, Peter C.
A1  - Horn, Friedemann
T1  - Association of transcription factor APRF and protein kinase JAK1 with the IL-6 signal transducer gp130
N2  - Interleukin-6, leukemia inhibitory factor, oncostatin M. Interleukin-11, and cilialy neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenicaly relaled to the p91 subunit of the interferon-stimulated gene factor-(ISGF-3a). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3a p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1 associated with gp130. These data indicate that Jak family protein kinases may participate in IL-6 signaling and that APRF may be activated in a complex with gp130.
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42577
ER  - 
TY  - JOUR
A1  - Sendtner, Michael
A1  - Thoenen, Hans
T1  - Oxidative stress and motorneuron disease
N2  - Transgenic mice carrying mutated Cu/Zn superoxide dismutase genes provide insights into the pathogenesis of human motorneuron diseases and may be useful as models in the development and testing of therapies.
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42684
ER  - 
TY  - JOUR
A1  - Dittrich, Falk
A1  - Thoenen, Hans
A1  - Sendtner, Michael
T1  - Ciliary neurotrophic factor: pharmacokinetics and acute-phase response in rat
N2  - No abstract available
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42639
ER  - 
TY  - JOUR
A1  - Sendtner, Michael
A1  - Carroll, P.
A1  - Holtmann, B
A1  - Hughes, R. A.
A1  - Thoenen, H.
T1  - Ciliary Neurotrophic Factor
N2  - No abstract available
KW  - ciliary neuron
KW  - ciliary neurotrophic factor
KW  - motoneuron
KW  - nonneuronaI cells
KW  - homologous recombination
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42545
ER  -