TY  - JOUR
A1  - de Vreeze, Ronald S. A.
A1  - Coevorden, Frits van
A1  - Boerrigter, Lucie
A1  - Nederlof, Petra M.
A1  - Haas, Rick L.
A1  - Bras, Johannes
A1  - Rosenwald, Andreas
A1  - Mentzel, Thomas
A1  - de Jong, Daphne
T1  - Delineation of Chondroid Lipoma: An Immunohistochemical and Molecular Biological Analysis
JF  - Sarcoma
N2  - Aims 

Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocation (11;16). Here, we analyze CL and its histological mimics. 

Methods 

CL ( ) was compared to a variety of histological mimics ( ) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis, CCND1 and FUS were investigated as potential translocation partners. 

Results 

All CLs were strongly positive for CCND1. One of 4 myoepitheliomas, CCND1, was positive. In well-differentiated lipomatous tumors and in chondrosarcomas, CCND1 was frequently expressed, but all myxoid liposarcomas were negative. FISH analysis did not give support for direct involvement of CCND1 and FUS as translocation partners. 

Conclusions 

Chondroid lipoma is extremely rare and has several and more prevalent histological mimics. The differential diagnosis of chondroid lipomas can be unraveled using immunohistochemical and molecular support.
KW  - Lipom
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-135103
VL  - 2011
IS  - Article ID 638403
ER  - 
TY  - JOUR
A1  - Hartmann, Stefan
A1  - Lessner, Grit
A1  - Mentzel, Thomas
A1  - Kübler, Alexander C.
A1  - Müller-Richter, Urs
T1  - An adult spindle cell rhabdomyosarcoma in the head and neck region with long-term survival: a case report
N2  - Introduction

Spindle cell rhabdomyosarcoma of the head and neck is a very rare tumor in adults. We report on one case with long-term survival.

Case presentation

A 41-year-old nonsmoking Caucasian man presented in June 2007 with a painless swelling under his tongue. A diagnosis of a soft tissue sarcoma, and a myofibrosarcoma in particular, was made via biopsy. After multimodal treatment, including local and systemic therapy, our patient remained disease-free until September 2010. The local recurrence was treated unsuccessfully with various chemotherapy regimens. In September 2011, our patient underwent surgical resection again, and a spindle cell rhabdomyosarcoma was diagnosed. To analyze the mismatch between the original diagnosis of a myofibrosarcoma and the second diagnosis, the two specimens were reassessed, and a final diagnosis of a spindle cell rhabdomyosarcoma was made. In 2012 and 2013, our patient suffered further recurrences that were surgically treated, and he is still alive with disease six years and 10 months after the initial diagnosis in June 2007.

Conclusions

In adults, the spindle cell rhabdomyosarcoma tumor is very rare in the head and neck region. In contrast to childhood tumors, spindle cell rhabdomyosarcoma in adulthood is often associated with a poor prognosis. In the present case, the radical surgical treatment might have helped to prolong the patient’s overall survival, which has lasted more than six years. To our knowledge, this is the longest overall survival reported so far for this tumor entity in the head and neck region.
KW  - Rhabdomyosarcoma
KW  - Spindle cell
KW  - Adult
KW  - Surgery
KW  - Head
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-110362
ER  -