TY  - JOUR
A1  - Hannig, Gerhard
A1  - Ottilie, Sabine
A1  - Schartl, Manfred
T1  - Conservation of structure and expression of the c-yes and fyn genes in lower vertebrates
N2  - The src-gene family in mammals and birds consists of 9 closely related protein tyrosine kinases. We have cloned the c-yes and fyn bomologues of the src-family from the teleost fish Xiphophorus helleri. Both genes show a high degree of sequence conservation and exhibit all structural motifs diagnostic for functional src-like protein tyrosine kinases. Sequence comparisons revealed three domains (exon 2, exons 3--6, exons 7-12) which evolve at different rates. Both genes exhibit an identical expression pattern, with preferential expression in neural tissues. No transcripts of c-yes were found in liver wbich is contrary to the situation in higher vertebrales. In malignant melanoma, elevated Ieveis of c-yes andfyn were detected indicating a possible function during secondary steps of tumor progression for src-related tyrosine kinases.
KW  - Konservierung
KW  - Gen
KW  - Niedere Wirbeltiere
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86723
ER  - 
TY  - CHAP
A1  - Anders, F.
A1  - Scholl, E.
A1  - Schartl, Manfred
T1  - Environmental and hereditary factors in the causation of neoplasia, based on studies of the Xiphophorus fish melanoma system
N2  - Neoplasia in Xiphophorus can be classified into: a) a Jarge group triggered by carcinogens; b) a large group triggered by promoters; and c) a small group that develops "spontaneously" according to Mendelian Jaw. The process leading to susceptibility for neoplasia is represented by the disintegration of gene systems that normally protect the fish from neoplasia. Interpopulational arid interracial hybridization is the most effective process that Ieads to disintegration of the protective gene systems. Environmental factors may complete disintegration in somatic cells and thus may trigger neoplasia. The applications of the findings on Xiphophorus to humans are discussed.
KW  - Schwertkärpfling
KW  - Gen
KW  - Umweltfaktor
KW  - Tumor
Y1  - 1981
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86402
ER  - 
TY  - CHAP
A1  - Anders, F.
A1  - Schartl, Manfred
A1  - Scholl, E.
T1  - Evaluation of environmental and hereditary factors in carcinogenesis, based on studies in Xiphophorus
N2  - Neoplasia in Xiphophorus can be classified into a) a large group that is triggered by carcinogens; b) a large group triggered by promoters; c) a small group that develops "spontaneously" following interpopulational and interracial hybridizations; and d) a small group that develops "spontaneously" following germ line mutation. The process leading to susceptibility for neoplasia is represented by the disintegration of gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene systems. Environmental factors may complete disintegration and thus may trigger neoplasia. It is discussed whether the findings on Xiphophorus may also apply to humans.
KW  - Schwertkärpfling
KW  - Gen
KW  - Umweltfaktor
KW  - Carcinogenese
Y1  - 1981
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-72741
ER  -