TY - JOUR A1 - Tacke, Reinhold A1 - Wiesenberger, Frank T1 - (Acetoxymethyl)methylphenylgerman: Synthese, thermisches Verhalten und olfaktorische Eigenschaften T1 - (Acetoxymethyl)methylphenylgermane: Synthesis, Thermal Behaviour and Olfactoric Properties N2 - No abstract available. KW - Chemische Synthese KW - Temperaturabhängigkeit KW - Olfaktorische Analyse KW - (Acetoxymethyl)methylphenylgermane KW - (Acetoxymethyl)methylphenylsilane KW - hydratropyl acetate KW - thermal stability KW - perfumes Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86927 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wiesenberger, F. A1 - Becker, B. A1 - Rohr-Aehle, R. A1 - Schneider, P. B. A1 - Ulbrich, U. A1 - Sarge, S. M. A1 - Cammenga, H. K. A1 - Koslowski, T. A1 - Niessen, W. von T1 - Ester von (Hydroxymethyl)diorganylsilanen: Synthese und thermisch induzierte Umlagerung T1 - Esters of (Hydroxymethyl)diorganylsllanes: Synthesis and Thermally Induced Rearrangement N2 - Twenty silanes of the type R\(^1\)R\(^2\)Si(H)CH\(_2\)OR\(^3\) (A) were syn- and entropy of activation) of these reactions were studied by thesized {R\(^1\), R\(^2\) = Me, Ph, 1-naphthyl, PhCH\(_2\), Me\(_3\)SiCH\(_2\); OR\(^3\) means of düferential scanning calorimetry (DSC). In addition, = OC(O)Me, OC(O)Ph, OC(O)CF\(_3\) , OS(0)\(_2\)CF\(_3\), OP(O)Ph\(_2\), the kinetics of all reactions were investigated by 1H-NMR OC(O)Cl, and studied for their thermal behaviour. The silanes spectroscopy. The transition state of the rearrangement was A undergo a thermally induced rearrangement to give the investigated by an ab initio study based on the model comcorresponding silanes R\(^1\)R\(^2\)Si(OR\(^3\))Me (B). For compounds with pound H\(_3\)SiCH\(_2\)OC(O)H (-> MeH\(_2\)SiOC(O)H]. The theoretical OR3 = OC(O)Cl, an additional decarboxylation takes place to data and the experimentally obtained energetic and kinetic yield the chlorosilanes R1R2Si(Cl)Me. Except for the deriva- data are discussed in terms of mechanistic aspects of the retives with OR\(^3\) = OC(O)Cl, the energetic (reaction enthalpy) arrangement reaction A -> B. and kinetic data (reaction order, frequency factor, enthalpy ... KW - Anorganische Chemie Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64188 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analoga des Mephenhydramins T1 - Sila-Analogues of Mephenhydramine N2 - Sila-Analogues A 2, B 2 and C 2 of the drug mephenhydramine from the class of benzhydryl ethers were synthesized for the first time by the steps shown in scheme 1, and they and their precursors I-V characterized by their physical {table 1) and chemical properties, and their structures confirmed by NMR, n1ass and infrared spectroscopy (tables 3-5). Their physiological effects were investigated a.nd compared -with those of the parent carbon compounds (section 5). KW - Anorganische Chemie Y1 - 1975 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63525 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analoga des Chlorphenoxamins und des Clofenetamins T1 - Sila-Analogues of Ohlorphenoxamine and Clofenetamine N2 - Sila-ana.logues A 2 and B 2 of two drugs from the benzhydryl ether class, chlorphenoxamine and clofenetamine, were synthesized for the first time by the steps shown in scheme 1. They and their precursors I-VI v;rere characterized by their physical (Table 1) and chemical properties and their structures confirmed by n.m.r., mass and infrared spectroscopy (Tab]es 2-5). Their physiological effects were invest.igated and compared with those of the carbon analogues (Chapter 5). KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63531 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analoga des Mebrophenhydramins T1 - Sila-Analogues of Mebrophenhydramine N2 - Sila-analogues A 2, B 2 and C 2 of the drug mebrophenhydramine from the class of benzhydryl ethers -were synthesized for the first time by the steps shown in scheme 1, and they and their precurso:rs I-Ill were characterized by their physical (Table 1) and chemical properties, a.nd their structures confirmed by NMR, mass and infrared spectroscopy (Tables 3-5). The histaminolytic and anticholinergic effects of A 2 and C 2 were investigated and compared with some structure-activity relationships of analogue carbon compounds. KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63542 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analogon des Cicloniumbromids T1 - Sila-Analogue of Ciclonium Bromide N2 - Sila-Analogues B 2 and A 2 of the spasmolytic ciclonium bromide (B 1) respectively the corresponding free base A 1 were synthesized for the first time according to the reaction steps sho·wn in scheme 1, and they and their precursors I and II were characterized by ph;ysical (Table 1} and chemical properties and their structures confirmed by NMR, and mass spectroscopy (Tables 2 and 3}. The pharmacological effects of A 2 and B 2 were investigated and compared with those of the parent carbon compound B 1 (chapter 5). KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63556 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Derivate des Sila-Mephenhydramins und Sila-Chlorphenoxamins T1 - Derivatives of Sila-Mephenhydramine and Sila-Ohlorphenoxamine N2 - Derivatives A and B of the two sila-antihistam.ines silamephenhydramine and sila-chlorphenoxamine were synthesized for the first time by the steps shown in scheme 1. They and their precursors III and IV were characterized by their physical (Table 1) and chemical properties and their structures confirmed by NMR and mass spectroscopy (Tables 2 and 3). Their pharmacological effects were investigated and compared with those of the corresponding sila-antihistamines. KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63562 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Isoelektronische Derivate des Sila-Clofenetamins und des Sila-Mebrophenhydramins T1 - Isoelectronic Derivatives of Sila-Clofenetamine and Sila-Mebrophenhydramine N2 - Isoelectronic derivatives (A and B) and a homolog (C) of the two sila-antihistamines sila-clofenetamine and silamebrophenhydramine were synthesized for the first time by the steps shown in scheme 1. They and their unknown precursors II-IV were characterized by their physical (Table 1) and chemical properties and their structures confinned by lH-NMR and rnass spectroscopy (Tables 2 and 3). The pharrnacological effects of A and B were investigated and compared with those of the corresponding 0-isosteric sila-antihistarnines (Chapter 5). KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63574 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - N-Quaternäre Derivate basischer Sila-benzhydryläther T1 - N-Quaternary Derivatives of Basic Silabenzhydryl Ethers N2 - Die quartären Ammoniumsalze 1-10 einiger bioaktiver Sila-benzhydryläther wurden erstmalig durch Reaktion der entsprechenden freien Basen A-E mit CH\(_3\)J, CH\(_3\)Br bzw. CH\(_3\)Cl in CH\(_3\)CN dargestellt. Die Strukturen von 1-10 wurden durch Elementaranalysen und 1 H-NMR-Spektren bestätigt. Die pharmakologischen Effekte einiger Verbindungen wurden sowohl mit den Eigenschaft der entsprechenden freien Basen als auch mit einigen Struktur-Wirkungsbeziehungen analoger Kohlenstoffverbindungen verglichen. N2 - Quaternary ammonium salts 1-10 of some biologically active silabenzhydryl ethers were synthesized for the frrst time by the reaction of the corresponding free bases A-E with CH\(_3\)I, CH\(_3\)Br or CH\(_3\)Cl in CH\(_3\)CN. The structures of 1-10 were confirmed by elementary analysis and 1 HNMR spectroscopy. The pharmacological effects of some compounds were compared with those of the corresponding free bases and of analogaus carbon cornpounds. KW - Anorganische Chemie Y1 - 1977 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63583 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wagner, S. A. A1 - Sperlich, J. T1 - Synthese von (-)-(Acetoxymethyl)(hydroxy-methyl)methyl(phenyl)german [(-)-MePhGe(CH\(_2\)OAc)(CH\(_2\)OH)] durch eine Esterase-katalysierte Umesterung: Die erste enzymatische Synthese eines optisch aktiven Germans N2 - No abstract available. KW - Anorganische Chemie KW - Germane KW - optically active KW - Biotransformation KW - stereoselective Transesterification KW - enzymatic KW - Porcine liver esterase Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64310 ER -