TY - JOUR A1 - Pimentel-Elardo, Sheila M. A1 - Buback, Verena A1 - Gulder, Tobias A. M. A1 - Bugni, Tim S. A1 - Reppart, Jason A1 - Bringmann, Gerhard A1 - Ireland, Chris M. A1 - Schirmeister, Tanja A1 - Hentschel, Ute T1 - New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities N2 - Four new tetromycin derivatives, tetromycins 1–4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001T cultivated from the Mediterranean sponge Axinella polypoides. Structures were assigned using extensive 1D and 2D NMR spectroscopy as well as HRESIMS analysis. The compounds were tested for antiparasitic activities against Leishmania major and Trypanosoma brucei, and for protease inhibition against several cysteine proteases such as falcipain, rhodesain, cathepsin L, cathepsin B, and viral proteases SARS-CoV Mpro, and PLpro. The compounds showed antiparasitic activities against T. brucei and time-dependent inhibition of cathepsin L-like proteases with Ki values in the low micromolar range. KW - Biologie KW - tetromycin KW - anti-trypanosomal KW - protease inhibition KW - Streptomyces axinellae KW - marine sponge Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-75465 ER -