TY  - JOUR
A1  - Tsai, Yu-Chen
A1  - Grimm, Stefan
A1  - Chao, Ju-Lan
A1  - Wang, Shih-Chin
A1  - Hofmeyer, Kerstin
A1  - Shen, Jie
A1  - Eichinger, Fred
A1  - Michalopoulou, Theoni
A1  - Yao, Chi-Kuang
A1  - Chang, Chih-Hsuan
A1  - Lin, Shih-Han
A1  - Sun, Y. Henry
A1  - Pflugfelder, Gert O.
T1  - Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling
JF  - PLoS ONE
N2  - Organ formation requires a delicate balance of positive and negative regulators. In Drosophila eye development, wingless (wg) is expressed at the lateral margins of the eye disc and serves to block retinal development. The T-box gene optomotor-blind (omb) is expressed in a similar pattern and is regulated by Wg. Omb mediates part of Wg activity in blocking eye development. Omb exerts its function primarily by blocking cell proliferation. These effects occur predominantly in the ventral margin. Our results suggest that the primary effect of Omb is the blocking of Jak/STAT signaling by repressing transcription of upd which encodes the Jak receptor ligand Unpaired.
KW  - morphogenetic furrow progression
KW  - cell fate
KW  - compartment boundary
KW  - reporter gene
KW  - compound eye
KW  - gene expression
KW  - retinal differentiation
KW  - acts downstream
KW  - imaginal disk
KW  - glial cells
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-143577
VL  - 10
IS  - 3
ER  -