TY  - JOUR
A1  - Miras, Alexander D.
A1  - Seyfried, Florian
A1  - Phinikaridou, Alkystis
A1  - Andia, Marcelo E.
A1  - Christakis, Ioannis
A1  - Spector, Alan C.
A1  - Botnar, Rene M.
A1  - le Roux, Carel W.
T1  - Rats Fed Diets with Different Energy Contribution from Fat Do Not Differ in Adiposity
JF  - OBESITY FACTS
N2  - Objective: To determine whether rats reaching the same body mass, having been fed either a low-fat (LFD) or a high-fat diet (HFD), differ in white adipose tissue (WAT) deposition. Methods: In experiment 1, 22 Sprague-Dawley rats of the same age were divided into 11 rats with body mass below the batch median and fed a HFD, and 11 above the median and fed a LFD. In experiment 2, 20 Sprague-Dawley rats of the same age and starting body mass were randomised to either a HFD or LFD. When all groups reached similar final body mass, WAT was quantified using magnetic resonance imaging (MRI), dissection, and plasma leptin. Results: In experiment 1, both groups reached similar final body mass at the same age; in experiment 2 the HFD group reached similar final body mass earlier than the LFD group. There were no significant differences in WAT as assessed by MRI or leptin between the HFD and LFD groups in both experiments. Dissection revealed a trend for higher retroperitoneal and epididymal adiposity in the HFD groups in both experiments. Conclusions: We conclude that at similar body mass, adiposity is independent of the macronutrient composition of the feeding regimen used to achieve it. (C) 2014 S Karger GmbH, Freiburg
KW  - Leptin
KW  - body fat
KW  - induced obesity
KW  - visceral fat
KW  - isocaloric intake
KW  - mass
KW  - tissue
KW  - weight-gain
KW  - metabolism
KW  - expenditure
KW  - accumulation
KW  - High-fat diet
KW  - Low-fat diet
KW  - MRI
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-115249
VL  - 7
IS  - 5
ER  -