TY  - JOUR
A1  - Okoro, Chinyere K.
A1  - Barquist, Lars
A1  - Connor, Thomas R.
A1  - Harris, Simon R.
A1  - Clare, Simon
A1  - Stevens, Mark P.
A1  - Arends, Mark J.
A1  - Hale, Christine
A1  - Kane, Leanne
A1  - Pickard, Derek J.
A1  - Hill, Jennifer
A1  - Harcourt, Katherine
A1  - Parkhill, Julian
A1  - Dougan, Gordon
A1  - Kingsley, Robert A.
T1  - Signatures of adaptation in human invasive Salmonella Typhimurium ST313 populations from sub-Saharan Africa
JF  - PLoS Neglected Tropical Diseases
N2  - Two lineages of Salmonella enterica serovar Typhimurium (S. Typhimurium) of multi-locus sequence type ST313 have been linked with the emergence of invasive Salmonella disease across sub-Saharan Africa. The expansion of these lineages has a temporal association with the HIV pandemic and antibiotic usage. We analysed the whole genome sequence of 129 ST313 isolates representative of the two lineages and found evidence of lineage-specific genome degradation, with some similarities to that observed in S. Typhi. Individual ST313 S. Typhimurium isolates exhibit a distinct metabolic signature and modified enteropathogenesis in both a murine and cattle model of colitis, compared to S. Typhimurium outside of the ST313 lineages. These data define phenotypes that distinguish ST313 isolates from other S. Typhimurium and may represent adaptation to a distinct pathogenesis and lifestyle linked to an-immuno-compromised human population.
KW  - genome sequence
KW  - infection
KW  - pathogenicity
KW  - children
KW  - disease
KW  - adults
KW  - identification
KW  - Escherichia coli
KW  - virulence
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-143779
VL  - 9
IS  - 3
ER  -