TY  - JOUR
A1  - Pötter-Nerger, Monika
A1  - Reese, Rene
A1  - Steigerwald, Frank
A1  - Heiden, Jan Arne
A1  - Herzog, Jan
A1  - Moll, Christian K. E.
A1  - Hamel, Wolfgang
A1  - Ramirez-Pasos, Uri
A1  - Falk, Daniela
A1  - Mehdorn, Maximilian
A1  - Gerloff, Christian
A1  - Deuschl, Günther
A1  - Volkmann, Jens
T1  - Movement-Related Activity of Human Subthalamic Neurons during a Reach-to-Grasp Task
JF  - Frontiers in Human Neuroscience
N2  - The aim of the study was to record movement-related single unit activity (SUA) in the human subthalamic nucleus (STN) during a standardized motor task of the upper limb. We performed microrecordings from the motor region of the human STN and registered kinematic data in 12 patients with Parkinson’s disease (PD) undergoing deep brain stimulation surgery (seven women, mean age 62.0 ± 4.7 years) while they intraoperatively performed visually cued reach-to-grasp movements using a grip device. SUA was analyzed offline in relation to different aspects of the movement (attention, start of the movement, movement velocity, button press) in terms of firing frequency, firing pattern, and oscillation. During the reach-to-grasp movement, 75/114 isolated subthalamic neurons exhibited movement-related activity changes. The largest proportion of single units showed modulation of firing frequency during several phases of the reach and grasp (polymodal neurons, 45/114), particularly an increase of firing rate during the reaching phase of the movement, which often correlated with movement velocity. The firing pattern (bursting, irregular, or tonic) remained unchanged during movement compared to rest. Oscillatory single unit firing activity (predominantly in the theta and beta frequency) decreased with movement onset, irrespective of oscillation frequency. This study shows for the first time specific, task-related, SUA changes during the reach-to-grasp movement in humans.
KW  - subthalamic nucleus
KW  - deep brain stimulation
KW  - Parkinson’s disease
KW  - neurophysiology
KW  - beta oscillation
KW  - reach-to-grasp movement
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-170361
VL  - 11
IS  - 436
ER  -