TY  - JOUR
A1  - Lyutova, Radostina
A1  - Selcho, Mareike
A1  - Pfeuffer, Maximilian
A1  - Segebarth, Dennis
A1  - Habenstein, Jens
A1  - Rohwedder, Astrid
A1  - Frantzmann, Felix
A1  - Wegener, Christian
A1  - Thum, Andreas S.
A1  - Pauls, Dennis
T1  - Reward signaling in a recurrent circuit of dopaminergic neurons and peptidergic Kenyon cells
JF  - Nature Communications
N2  - Dopaminergic neurons in the brain of the Drosophila larva play a key role in mediating reward information to the mushroom bodies during appetitive olfactory learning and memory. Using optogenetic activation of Kenyon cells we provide evidence that recurrent signaling exists between Kenyon cells and dopaminergic neurons of the primary protocerebral anterior (pPAM) cluster. Optogenetic activation of Kenyon cells paired with odor stimulation is sufficient to induce appetitive memory. Simultaneous impairment of the dopaminergic pPAM neurons abolishes appetitive memory expression. Thus, we argue that dopaminergic pPAM neurons mediate reward information to the Kenyon cells, and in turn receive feedback from Kenyon cells. We further show that this feedback signaling is dependent on short neuropeptide F, but not on acetylcholine known to be important for odor-shock memories in adult flies. Our data suggest that recurrent signaling routes within the larval mushroom body circuitry may represent a mechanism subserving memory stabilization.
KW  - Learning and memory
KW  - Neural circuits
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-202161
VL  - 10
ER  - 
TY  - JOUR
A1  - Pauls, Dennis
A1  - Blechschmidt, Christine
A1  - Frantzmann, Felix
A1  - el Jundi, Basil
A1  - Selcho, Mareike
T1  - A comprehensive anatomical map of the peripheral octopaminergic/tyraminergic system of Drosophila melanogaster
JF  - Scientific Reports
N2  - The modulation of an animal’s behavior through external sensory stimuli, previous experience and its internal state is crucial to survive in a constantly changing environment. In most insects, octopamine (OA) and its precursor tyramine (TA) modulate a variety of physiological processes and behaviors by shifting the organism from a relaxed or dormant condition to a responsive, excited and alerted state. Even though OA/TA neurons of the central brain are described on single cell level in Drosophila melanogaster, the periphery was largely omitted from anatomical studies. Given that OA/TA is involved in behaviors like feeding, flying and locomotion, which highly depend on a variety of peripheral organs, it is necessary to study the peripheral connections of these neurons to get a complete picture of the OA/TA circuitry. We here describe the anatomy of this aminergic system in relation to peripheral tissues of the entire fly. OA/TA neurons arborize onto skeletal muscles all over the body and innervate reproductive organs, the heart, the corpora allata, and sensory organs in the antennae, legs, wings and halteres underlining their relevance in modulating complex behaviors.
KW  - neural circuits
KW  - peripheral nervous system
KW  - Drosophila melanogaster
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-177412
VL  - 8
IS  - 15314
ER  -